START UP, PREPARATION, AND TEST ENROLLMENT FOR THE TIMING OF DELIVERY (TIME) AIM OF THE STUDY OF PREGNANCY AND NEONATAL HEALTH (SPAN)

启动、准备和测试 分娩时间（时间） 妊娠和新生儿健康研究的目标（跨度）

• 批准号: 10271530
• 负责人: ROBERT SILVER
• 金额: $ 94.7万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-28 至 2021-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10271530
• 关键词: Acceleration; Address; African American; Age; Aging; Anthropometry; Behavioral; Behavioral Sciences; Biochemical; Bioinformatics; Biological Process; Biometry; Birth; Blood Pressure; Body fat; Characteristics; Childhood; Chronic Disease; Clinical; Cohort Studies; Common Data Element; Development; Disease; Enrollment; Epidemiology; Epigenetic Process; Fetal Growth; Fetal Mortality Statistics; Fibrinogen; Gene Expression; Genetic; Gestational Diabetes; Glucose; Glycosylated hemoglobin A; Growth and Development function; Health; Health behavior; Human; Individual; Intramural Research; Life; Link; Measures; Mission; National Institute of Child Health and Human Development; Neonatal; Neonatal Mortality; Newborn Infant; Pregnancy; Pregnancy Complications; Pregnant Women; Preparation; Public Health; Reproduction; Research; Research Methodology; Seminal fluid; Site; Social Sciences; Testing; Time; Ultrasonography; Variant; Woman; adolescent health; arterial stiffness; behavioral outcome; cardiovascular disorder risk; cohort; design; disorder risk; early life exposure; early pregnancy; father role; fetal; genomic locus; male; neonatal morbidity; neonatal outcome; neonate; population health; prenatal exposure; programs; prospective; randomized trial; recruit; waist circumference

The Division of Intramural Population Health Research (DIPHR) at the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) designs and conducts original epidemiological, behavioral, and biostatistical research encompassing several research domains such as human reproduction and development, pregnancy and related complications, pediatric and adolescent health and behaviors, and methodologic research relevant for our mission. The Division comprises three intramural research branches, Epidemiology, Biostatistics & Bioinformatics, and Social and Behavioral Sciences, and its mission is to design and implement original research with the potential for high impact findings that impact public health. Under the developmental origins of health and disease (DOHaD) hypothesis, early life exposures can “program” an individual for health and chronic disease risk through cellular adaptations to biological processes. Prenatal exposures and genetic factors impact fetal growth and development and neonatal health, important determinants of life-long health and disease. We propose an approach to examine a) the father’s role, b) placental determinants, and c) timing of delivery in relation to fetal and neonatal health and development. A cohort study will be performed to collect common data elements from approximately 10,728 pregnant women and their neonates and approximately 3825 male partners with a randomized trial conducted in women with gestational diabetes (approximately 3450 women, an addition of 2730). African American women will be oversampled (~4250). It is anticipated that multiple study sites will be established.

尤尼斯·肯尼迪·施赖弗校内人口健康研究部 (DIPHR) 国家儿童健康与人类发展研究所 (NICHD) 设计并进行原创 流行病学、行为学和生物统计学研究，涵盖多个研究领域，例如 如人类生殖和发育、怀孕及相关并发症、儿科和 青少年健康和行为以及与我们的使命相关的方法研究。该司 包括三个校内研究分支：流行病学、生物统计学和生物信息学，以及 社会和行为科学，其使命是设计和实施原创研究 影响公共健康的高影响力发现的潜力。 根据健康与疾病的发育起源（DOHaD）假说，生命早期的暴露可以 通过细胞适应来“规划”个体的健康和慢性病风险 生物过程。产前暴露和遗传因素影响胎儿生长发育 和新生儿健康，终生健康和疾病的重要决定因素。我们提出一个方法 检查 a) 父亲的角色，b) 胎盘决定因素，以及 c) 分娩时间的关系 有利于胎儿和新生儿的健康和发育。将进行队列研究以收集常见的 来自约 10,728 名孕妇及其新生儿和约 3825 名孕妇及其新生儿的数据元素 男性伴侣在患有妊娠糖尿病的女性中进行了一项随机试验（大约 3450 名女性，新增 2730 名）。非裔美国女性将被过度抽样（~4250）。预计多个 将设立研究点。