EFFECTS OF ASPIRIN IN GESTATION AND REPRODUCTION (EAGER)

阿司匹林对妊娠和生殖的影响（EAGER）

• 批准号: 7937135
• 负责人: ROBERT SILVER
• 金额: $ 98.55万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7937135
• 关键词: EFFECTS; ASPIRIN; GESTATION; REPRODUCTION; EAGER

Despite the fundamental nature of reproduction, for many it is a process fraught with frustration, inefficiency and imperfections. Infertility affects 10 to 15 percent of couples attempting to conceive. Among all women who conceive, the incidence of spontaneous miscarriage has been estimated at between 15 and 31 percent, and in many cases the cause is unknown. Additionally, of the four million infants born each year in the United States, between eight and 15 percent will be born prematurely and as a result, will experience higher morbidity and mortality, compared with full-term infants. . An intervention with even a small relative effect on preventing the occurrence of any of these adverse outcomes has great implications at the population level because of the large potential attributable benefit. For this reason, the Epidemiology Branch of DESPR Intramural research at the NICHD is conducting a multi-site randomized trial to evaluate the effect of daily low-dose aspirin and folic acid, compared folic acid and placebo alone, on reproduction at all phases, beginning at preconception and continuing throughout pregnancy. The trial will assess the effects of aspirin on each of the phases, including implantation and live birth. The trial has the goal of recruiting and completing the intervention in a sample of at least 1,600 women, age 18-40, who have previously experienced one or two pregnancy losses and who are actively trying to conceive.

尽管再生产具有根本性，但对许多人来说，这是一个充满挫折、效率低下和不完美的过程。不孕症影响了10%到15%试图怀孕的夫妇。在所有怀孕的妇女中，自发流产的发生率估计在15%到31%之间，在许多情况下，原因是未知的。此外，在美国每年出生的400万婴儿中，8%至15%将早产，因此，与足月婴儿相比，发病率和死亡率将更高。.即使干预措施对预防任何这些不良后果的发生具有很小的相对影响，但由于其潜在的可归因效益，在人群水平上也具有很大的影响。因此，NICHD DESPR校内研究的流行病学分支正在进行一项多中心随机试验，以评估每日低剂量阿司匹林和叶酸对生殖的影响，并与叶酸和安慰剂单独比较，从孕前开始，持续到整个怀孕期间。该试验将评估阿司匹林对每个阶段的影响，包括植入和活产。该试验的目标是招募并完成至少1，600名年龄在18-40岁之间的女性样本的干预，这些女性以前经历过一次或两次妊娠失败，并且正在积极尝试怀孕。