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Disrupting Type IV secretion function to prevent virulence in the pathogenic bacterium Legionella pneumophila

Disrupting Type IV secretion function to prevent virulence in the pathogenic bacterium Legionella pneumophila
破坏 IV 型分泌功能以防止致病菌嗜肺军团菌的毒力
批准号：
10269713
负责人：
Anton Simeonov
金额：
$18.66万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10269713
关键词：
Alveolar MacrophagesAmoeba genusBiological AssayCellsCoxiellaEnvironmentFresh WaterGrowthImmune responseInfectionLegionella pneumophilaLegionnaires&apos DiseasePneumoniaProcessProteinsReporterSignal TransductionSystemToxinType IV Secretion System PathwayValidationVirulencedesignnovel therapeuticspathogenpathogenic bacteriapreventscreeningsmall moleculetrafficking

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英文摘要
During this period, the project team designed a new screening approach that strongly favored identification of compounds that interfere with the process of reporter translocation by directly targeting the bacterial T4SS rather than processes within host cells. Primary screening of tens of thousands of molecules was successfully completed, and hit molecules were cherry-picked and retested for validation. Select hits were further assessed to determine their efficacies in a variety of biological assays that require a functional T4SS, for example in Coxiella Burnetti.
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