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Activation-induced cytidine deaminase

Activation-induced cytidine deaminase
激活诱导的胞苷脱氨酶
批准号：
10011394
负责人：
Anton Simeonov
金额：
$25.03万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10011394
关键词：
AntibodiesB-Cell ActivationBiological AssayBiological ProcessCytosineCytosine deaminaseDNADNA Double Strand BreakDNA RepairDeaminationDevelopmentDrug resistanceFluorescence Resonance Energy TransferGenomeIGH@ gene clusterImmunoglobulin Class SwitchingImmunoglobulin Somatic HypermutationImmunoglobulin Switch RecombinationImmunoglobulin Variable RegionIn VitroMusMutagenesisMutationPlayPoint MutationRoleSplenocyteStretchingUracilWorkactivation-induced cytidine deaminaseanti-cancer therapeuticbasecancer cellinhibitor/antagonistnovelscreeningsmall molecule librariestumor initiation

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英文摘要
This project aims to identify novel AID inhibitors as potential anticancer therapeutics. The project team intends to screen NCGC small molecule libraries using FRET-based analysis of cytosine deamination to identify potential inhibitors of AID catalytic activity. Identified hits will be examined in an in vitro murine B-cell activation assay to confirm biological function, and select validated hit molecules will be further characterized in wild type primary splenocytes to identify molecules with inhibitory efficacy in the appropriate range. During this period, the project team worked to conceptualize and optimize a high-throughput amenable assay to enable screening of NCGC's chemical libraries.
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