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Identification of inhibitors of Zika Protease (NS2B-NS3)

Identification of inhibitors of Zika Protease (NS2B-NS3)
寨卡蛋白酶 (NS2B-NS3) 抑制剂的鉴定
批准号：
10005788
负责人：
Anton Simeonov
金额：
$13.27万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10005788
关键词：
Biological AssayChemicalsCollaborationsDiseaseDisease OutbreaksExtramural ActivitiesGenomicsGoalsInformaticsLinkModelingPeptide HydrolasesPharmaceutical ChemistryPolyproteinsProcessProtease InhibitorResearchUnited States National Institutes of HealthValidationVirus InhibitorsWorkZika Virusdrug discoveryinhibitor/antagonistnervous system disordernovelscreeningsmall moleculesmall molecule inhibitorsmall molecule therapeuticstherapeutic development

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中文摘要
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英文摘要
The recent rise of Zika virus (ZIKV) outbreaks has been linked to severe neurological disorders. ZIKV relies on the activity of the NS2B/NS3 protease for polyprotein processing, and the collaborative team aims to uncover novel small molecule inhibitors of this viral protease. During this period, the NCGC and collaborative team worked to optimize and validate a high-throughput NS2B assay and conduct primary screening; validation and characterization of identified hit molecules is currently underway.
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