Quit4Life+: Adapting and Evaluating a Phone-Based Tobacco Use Cessation Program for People Living with HIV in Uganda and Zambia

Quit4Life：针对乌干达和赞比亚艾滋病毒感染者调整和评估基于电话的戒烟计划

• 批准号: 10269613
• 负责人: Heather L Wipfli
• 金额: $ 69.08万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10269613
• 关键词: Abstinence; Acquired Immunodeficiency Syndrome; Africa; Africa South of the Sahara; African; Alcohol consumption; Antiviral Therapy; Awareness; Behavioral; Biochemical; Cardiovascular Diseases; Cause of Death; Chronic Obstructive Airway Disease; Communities; Country; Data; Disease; Enrollment; Ensure; Environment; General Population; Goals; HIV; Health Personnel; Health Professional; Health behavior; Healthcare; Intervention; Low income; Lung; Malignant Neoplasms; Measures; Mental Health; Morbidity - disease rate; Nicotine Dependence; Outcome; Participant; Patient Self-Report; Pattern; Pharmacology; Pneumonia; Policies; Population; Positioning Attribute; Prevalence; Provider; Public Health Schools; Randomized; Research; Resources; Risk; Risk Factors; Savings; Services; Smoke; Smoker; Smoking; Social isolation; Telephone; Testing; Text Messaging; Time; Tobacco; Tobacco Use Cessation; Tobacco use; Tuberculosis; Uganda; Universities; World Health Organization; Zambia; attributable mortality; base; brief advice; co-infection; comorbidity; comparative; comparative efficacy; control trial; cost; cost effective; cost effectiveness; cost estimate; cost-effectiveness ratio; depressive symptoms; design; disorder risk; efficacy evaluation; efficacy testing; health economics; improved; incremental cost-effectiveness; insight; interest; intervention effect; low and middle-income countries; low income country; mHealth; medical schools; mortality; nicotine patch; nicotine replacement; nicotine treatment; programs; scale up; secondary outcome; social stigma; standard of care; success; therapy adherence; tobacco cessation intervention; tobacco control; tobacco user; treatment arm; treatment center

Project Summary/Abstract While AIDS-related morbidity and mortality among people living with HIV (PLWH) have decreased with the introduction of combination antiviral therapy (ART), HIV continues to kill nearly 1 million people annually, the majority of whom live in sub-Saharan Africa. Tobacco use among PLWH contributes substantially to the HIV burden, with nearly a quarter of AIDS-related deaths attributable to smoking. While there is substantial evidence supporting interventions to help tobacco users in the general population quit, little is available relevant to the challenges facing HIV+ tobacco users, especially those living in low-income African countries, including higher rates of depressive symptoms, greater use of alcohol and illegal substances, lack of awareness about tobacco’s effects on HIV treatment, and social isolation resulting from HIV stigma. We approach this gap with the first randomized control trial (RCT) to test the efficacy of a tailored short message service (SMS) based tobacco use cessation intervention on prolonged tobacco use abstinence at 6 months post program initiation in comparison to the standard of care (brief advice to quit) and nicotine replacement therapy (nicotine patches) among PLWH in Uganda and Zambia. Our study will provide insight into the efficacy, feasibility, applicability, and affordability of delivering tobacco cessation interventions through health care professionals at HIV treatment centers in two countries with different tobacco use patterns, policy environments, and health care resources and provide needed information to providers and policymakers looking for cost-effective tobacco cessation interventions. The previously tested SMS-platform to be used in our study is uniquely positioned to be scaled in low- and middle-income countries worldwide, in which case rigorous research showing even modest success in reducing the prevalence of tobacco consumption among PLWH could confer enormous health and economic benefits. The primary partners in the study include the Center for Tobacco Control in Africa at the Makerere University School of Public Health, the Keck School of Medicine of USC; and the RAND Corporation; with technical support from the World Health Organization.

项目摘要/摘要 艾滋病毒（PLWH）的艾滋病相关的发病率和死亡率随着 引入抗病毒疗法（ART），HI​​V每年继续杀死近100万人 大多数人住在撒哈拉以南非洲。 PLWH中的烟草使用对艾滋病毒有很大贡献 负担，将近四分之一的与艾滋病有关的死亡归因于吸烟。虽然有实质性 支持干预措施以帮助烟草用户退出的证据，几乎没有可用 与艾滋病毒+烟草使用者相关的挑战，尤其是那些生活在低收入非洲国家的挑战， 包括更高的抑郁症状率，更多的酒精和非法物质，缺乏 意识到烟草对艾滋病毒治疗的影响以及艾滋病毒污名引起的社会隔离。我们 使用第一个随机对照试验（RCT）处理此差距，以测试量身定制的短消息的效率 服务（SMS）基于烟草对长时间的烟草使用戒烟在6个月时使用戒烟 与护理标准（简短的戒烟建议）和尼古丁更换相比 乌干达和赞比亚的PLWH中的治疗（尼古丁斑块）。我们的研究将为您提供有关 通过健康提供戒烟干预措施的功效，可行性，适用性和负担能力 艾滋病毒治疗中心的护理专业人员在两个国家使用不同的烟草使用模式，政策 环境和医疗保健资源，并向提供者和政策制定者提供所需的信息 寻找具有成本效益的烟草戒烟干预措施。以前测试的SMS平台用于 我们的研究唯一可以在全球的低收入和中等收入国家中缩放，在这种情况下 严格的研究表明，在降低烟草消费率的流行率方面甚至是适度的成功 PLWH可以赋予巨大的健康和经济利益。研究中的主要伴侣包括 凯克学校凯克学校的马克雷雷大学公共卫生学院非洲烟草控制中心 南加州大学的医学；和兰德公司；在世界卫生组织的技术支持下。