Quit4Life+: Adapting and Evaluating a Phone-Based Tobacco Use Cessation Program for People Living with HIV in Uganda and Zambia

Quit4Life：针对乌干达和赞比亚艾滋病毒感染者调整和评估基于电话的戒烟计划

• 批准号: 10686970
• 负责人: Heather L Wipfli
• 金额: $ 64.64万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686970
• 关键词: Abstinence; Acquired Immunodeficiency Syndrome; Africa; Africa South of the Sahara; African; Alcohol consumption; Antiviral Therapy; Awareness; Behavioral; Biochemical; Cardiovascular Diseases; Cause of Death; Chronic Obstructive Pulmonary Disease; Communities; Country; Data; Disease; Economics; Enrollment; Ensure; Environment; General Population; Goals; HIV; Health; Health Personnel; Health Professional; Health behavior; Healthcare; Intervention; Low income; Lung; Malignant Neoplasms; Measures; Mental Health; Morbidity - disease rate; Nicotine Dependence; Outcome; Participant; Patient Self-Report; Pattern; Persons; Pneumonia; Policies; Policy Maker; Population; Positioning Attribute; Prevalence; Provider; Public Health Schools; Randomized; Randomized, Controlled Trials; Research; Resources; Risk; Risk Factors; Services; Smoke; Smoker; Smoking; Social isolation; Telephone; Testing; Text Messaging; Time; Tobacco; Tobacco Use Cessation; Tobacco use; Tuberculosis; Uganda; Universities; World Health Organization; Zambia; attributable mortality; brief advice; co-infection; comorbidity; comparative; comparative efficacy; cost effective; cost effectiveness; cost estimate; cost-effectiveness ratio; depressive symptoms; design; disorder risk; efficacy evaluation; efficacy testing; improved; incremental cost; incremental cost-effectiveness; insight; interest; intervention effect; low and middle-income countries; low income country; mHealth; medical schools; mortality; nicotine patch; nicotine replacement; nicotine treatment; pharmacologic; programs; scale up; secondary outcome; social stigma; standard of care; success; therapy adherence; tobacco cessation intervention; tobacco control; tobacco user; treatment arm; treatment center

Project Summary/Abstract While AIDS-related morbidity and mortality among people living with HIV (PLWH) have decreased with the introduction of combination antiviral therapy (ART), HIV continues to kill nearly 1 million people annually, the majority of whom live in sub-Saharan Africa. Tobacco use among PLWH contributes substantially to the HIV burden, with nearly a quarter of AIDS-related deaths attributable to smoking. While there is substantial evidence supporting interventions to help tobacco users in the general population quit, little is available relevant to the challenges facing HIV+ tobacco users, especially those living in low-income African countries, including higher rates of depressive symptoms, greater use of alcohol and illegal substances, lack of awareness about tobacco’s effects on HIV treatment, and social isolation resulting from HIV stigma. We approach this gap with the first randomized control trial (RCT) to test the efficacy of a tailored short message service (SMS) based tobacco use cessation intervention on prolonged tobacco use abstinence at 6 months post program initiation in comparison to the standard of care (brief advice to quit) and nicotine replacement therapy (nicotine patches) among PLWH in Uganda and Zambia. Our study will provide insight into the efficacy, feasibility, applicability, and affordability of delivering tobacco cessation interventions through health care professionals at HIV treatment centers in two countries with different tobacco use patterns, policy environments, and health care resources and provide needed information to providers and policymakers looking for cost-effective tobacco cessation interventions. The previously tested SMS-platform to be used in our study is uniquely positioned to be scaled in low- and middle-income countries worldwide, in which case rigorous research showing even modest success in reducing the prevalence of tobacco consumption among PLWH could confer enormous health and economic benefits. The primary partners in the study include the Center for Tobacco Control in Africa at the Makerere University School of Public Health, the Keck School of Medicine of USC; and the RAND Corporation; with technical support from the World Health Organization.

项目摘要/摘要 虽然艾滋病毒携带者(PLWH)中与艾滋病相关的发病率和死亡率随着 随着联合抗病毒疗法(ART)的推出，艾滋病毒每年继续导致近100万人死亡， 他们中的大多数生活在撒哈拉以南非洲。公共卫生部门的烟草使用极大地促进了艾滋病毒的传播 与艾滋病有关的死亡中，有近四分之一可归因于吸烟。虽然有大量的 支持帮助普通人群戒烟的干预措施的证据很少 与艾滋病毒+烟草使用者，特别是生活在低收入非洲国家的吸烟者所面临的挑战有关， 包括更高的抑郁症状发生率，更多地使用酒精和非法物质，缺乏 认识到烟草对艾滋病毒治疗的影响，以及艾滋病毒污名造成的社会孤立。我们 用第一个随机对照试验(RCT)来弥补这一差距，以测试定制短信的有效性 基于服务(SMS)的戒烟干预对6个月内长期戒烟的影响 计划启动后与护理标准(戒烟简要建议)和尼古丁替代标准的比较 乌干达和赞比亚PLWH的治疗(尼古丁贴片)。我们的研究将为我们提供对 通过健康提供戒烟干预措施的有效性、可行性、适用性和可负担性 两个烟草使用模式、政策不同的国家艾滋病毒治疗中心的护理专业人员 环境和卫生保健资源，并向提供者和政策制定者提供所需信息 寻找成本效益高的戒烟干预措施。之前测试过的短信平台将用于 我们的研究处于独特的地位，可以在全球低收入和中等收入国家进行推广，在这种情况下 严谨的研究表明，即使在减少烟草消费流行率方面也取得了一定的成功 PLWH可以带来巨大的健康和经济利益。该研究的主要合作伙伴包括 马凯雷雷大学公共卫生学院非洲烟草控制中心，凯克学院 南加州大学医学院和兰德公司；由世界卫生组织提供技术支持。