Randomized-controlled trial of virtual reality for chronic low back pain to improve patient-reported outcomes and physical activity
虚拟现实治疗慢性腰痛的随机对照试验,以改善患者报告的结果和身体活动
基本信息
- 批准号:10267739
- 负责人:
- 金额:$ 83.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-25 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:3D virtual reality3D worldAbsence of pain sensationAchievementAcute PainAddressAdultBack PainBiofeedbackBiometryBrain imagingBreathing ExercisesBurn injuryCaloriesChronicChronic low back painClinicClinicalClinical TrialsCognitive TherapyControl GroupsDataDevicesEconomicsEsthesiaEvidence based treatmentFunctional Magnetic Resonance ImagingGogglesHarm ReductionHeadHealthHeart RateHigh Performance ComputingHydromorphoneImmersionImpairmentIndividualInterventionLinear RegressionsLiteratureLogistic RegressionsLogit ModelsMeasuresMedicalMeditationMental DepressionModalityModelingMonitorMusculoskeletal PainNociceptive StimulusOpiate AddictionOpioidOpioid AnalgesicsOutcomePainPain interferencePain managementPatient Outcomes AssessmentsPatient SelectionPatient-Focused OutcomesPatientsPharmaceutical PreparationsPharmacotherapyPhysical FunctionPhysical activityPredictive ValueProtocols documentationProviderQuality of lifeRandomizedRandomized Controlled TrialsReceiver Operating CharacteristicsReportingResearchRiskSafetySamplingSensorySeveritiesSleep disturbancesSocial FunctioningTestingTherapeuticTimeUnited States National Institutes of HealthVisual Cortexbaseburden of illnesschronic paincomorbiditycostdisabilitydistractionemotional functioningfallshealth related quality of lifeimprovedmortalityopioid useopioid use disorderpain patientpain reductionpredictive modelingprimary outcomepsychological distressresponseskillssleep qualitysleep quantitysociodemographicsstereoscopictreatment grouptreatment responsetwo-dimensionalvirtual environmentvirtual realityvirtual reality environmentvirtual reality headset
项目摘要
PROJECT SUMMARY
Chronic low back pain (cLBP) is a prevalent and costly condition that markedly impairs physical, emotional,
and social function. Despite its overwhelming burden of illness, with one in four adults reporting frequent back
pain, available drug therapies are limited in their ability to provide lasting benefits and improve health-related
quality of life (HRQOL). Patients with cLBP frequently turn to opioids when other pharmacotherapies fail to
provide adequate analgesia, yet often discover that opioids also fall short in delivering meaningful pain reduction
or improving HRQOL. Hence, there is a critical gap in pain management in cLBP; it is vital to address this
evidence gap in a way that maximizes benefits for patients while minimizing harms from medical therapy.
Therapeutic virtual reality (VR) has emerged as a promising and evidence-based treatment modality for
musculoskeletal pain, including cLBP. Users of VR wear a pair of goggles with a close-proximity stereoscopic
screen that creates a sensation of being transported into lifelike, three-dimensional worlds. By stimulating the
visual cortex while engaging other senses, VR modulates the user’s processing of nociceptive stimuli. Functional
magnetic resonance imaging (fMRI) of the brain reveals that VR has similar effects on the sensory and insular
cortex as opioids, and head-to-head trials show that VR achieves similar or greater analgesia as hydromorphone.
However, there are few data regarding long-term efficacy and safety of VR in cLBP. To date, VR has been limited
to short-term clinical trials. In addition, limited research exists on VR modalities beyond mere distraction, such
as VR therapy that teaches exportable skills using cognitive behavioral therapy (CBT), guided meditation, and
biofeedback-based breathing exercises.
To address these gaps, we propose to measure patient-reported outcomes (PROs), biometric outcomes, and
opioid use in 360 nonspecific cLBP patients randomized among 3 groups and followed for 90 days: (1) immersive
skills-based VR therapy; (2) immersive distraction VR therapy; and (3) non-immersive sham VR using 2D videos
displayed in a VR headset. The results will inform best practices for implementing VR in cLBP and identify
patient-level predictors of efficacy.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Brennan Spiegel其他文献
Brennan Spiegel的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Brennan Spiegel', 18)}}的其他基金
Transcending COVID-19 barriers to pain care in rural America: Pragmatic comparative effectiveness trial of evidence-based, on-demand, digital behavioral treatments for chronic pain
超越美国农村地区疼痛护理的 COVID-19 障碍:针对慢性疼痛的循证、按需、数字行为治疗的实用比较有效性试验
- 批准号:
10425444 - 财政年份:2021
- 资助金额:
$ 83.78万 - 项目类别:
Transcending COVID-19 barriers to pain care in rural America: Pragmatic comparative effectiveness trial of evidence-based, on-demand, digital behavioral treatments for chronic pain
超越美国农村地区疼痛护理的 COVID-19 障碍:针对慢性疼痛的循证、按需、数字行为治疗的实用比较有效性试验
- 批准号:
10610907 - 财政年份:2021
- 资助金额:
$ 83.78万 - 项目类别:
Transcending COVID-19 barriers to pain care in rural America: Pragmatic comparative effectiveness trial of evidence-based, on-demand, digital behavioral treatments for chronic pain
超越美国农村地区疼痛护理的 COVID-19 障碍:针对慢性疼痛的循证、按需、数字行为治疗的实用比较有效性试验
- 批准号:
10242572 - 财政年份:2021
- 资助金额:
$ 83.78万 - 项目类别:
Randomized-controlled trial of virtual reality for chronic low back pain to improve patient-reported outcomes and physical activity
虚拟现实治疗慢性腰痛的随机对照试验,以改善患者报告的结果和身体活动
- 批准号:
10671360 - 财政年份:2019
- 资助金额:
$ 83.78万 - 项目类别:
Randomized-controlled trial of virtual reality for chronic low back pain to improve patient-reported outcomes and physical activity
虚拟现实治疗慢性腰痛的随机对照试验,以改善患者报告的结果和身体活动
- 批准号:
10683125 - 财政年份:2019
- 资助金额:
$ 83.78万 - 项目类别:
Randomized-controlled trial of virtual reality for chronic low back pain to improve patient-reported outcomes and physical activity
虚拟现实治疗慢性腰痛的随机对照试验,以改善患者报告的结果和身体活动
- 批准号:
10896861 - 财政年份:2019
- 资助金额:
$ 83.78万 - 项目类别:
Randomized-controlled trial of virtual reality for chronic low back pain to improve patient-reported outcomes and physical activity (HEAL Supplement)
虚拟现实治疗慢性腰痛的随机对照试验,以改善患者报告的结果和身体活动(HEAL 补充)
- 批准号:
10650652 - 财政年份:2019
- 资助金额:
$ 83.78万 - 项目类别:
Randomized-controlled trial of virtual reality for chronic low back pain to improve patient-reported outcomes and physical activity: Understanding Patient Predictors of Response
虚拟现实治疗慢性腰痛的随机对照试验,以改善患者报告的结果和身体活动:了解患者反应的预测因素
- 批准号:
10350470 - 财政年份:2019
- 资助金额:
$ 83.78万 - 项目类别:
Randomized-controlled trial of virtual reality for chronic low back pain to improve patient-reported outcomes and physical activity
虚拟现实治疗慢性腰痛的随机对照试验,以改善患者报告的结果和身体活动
- 批准号:
10472620 - 财政年份:2019
- 资助金额:
$ 83.78万 - 项目类别:
Improving representation of non-Hispanic Black and Hispanic study participants in a trial of virtual reality for chronic lower back pain
改善慢性腰痛虚拟现实试验中非西班牙裔黑人和西班牙裔研究参与者的代表性
- 批准号:
10400468 - 财政年份:2019
- 资助金额:
$ 83.78万 - 项目类别:
相似海外基金
Building joint models of language and the 3D world
构建语言和 3D 世界的联合模型
- 批准号:
RGPIN-2020-07196 - 财政年份:2022
- 资助金额:
$ 83.78万 - 项目类别:
Discovery Grants Program - Individual
CAREER: Learning to Perceive the Interactive 3D World from an Image
职业:学习从图像感知交互式 3D 世界
- 批准号:
2142529 - 财政年份:2022
- 资助金额:
$ 83.78万 - 项目类别:
Continuing Grant
Building joint models of language and the 3D world
构建语言和 3D 世界的联合模型
- 批准号:
RGPIN-2020-07196 - 财政年份:2021
- 资助金额:
$ 83.78万 - 项目类别:
Discovery Grants Program - Individual
Building joint models of language and the 3D world
构建语言和 3D 世界的联合模型
- 批准号:
DGECR-2020-00310 - 财政年份:2020
- 资助金额:
$ 83.78万 - 项目类别:
Discovery Launch Supplement
Building joint models of language and the 3D world
构建语言和 3D 世界的联合模型
- 批准号:
RGPIN-2020-07196 - 财政年份:2020
- 资助金额:
$ 83.78万 - 项目类别:
Discovery Grants Program - Individual
Updating head direction in a 3D world
更新 3D 世界中的头部方向
- 批准号:
2091869 - 财政年份:2018
- 资助金额:
$ 83.78万 - 项目类别:
Studentship
Intelligent 3D world building from mobile terrestrial LiDAR point clouds
利用移动地面 LiDAR 点云构建智能 3D 世界
- 批准号:
311923-2013 - 财政年份:2017
- 资助金额:
$ 83.78万 - 项目类别:
Discovery Grants Program - Individual
Intelligent 3D world building from mobile terrestrial LiDAR point clouds
利用移动地面 LiDAR 点云构建智能 3D 世界
- 批准号:
311923-2013 - 财政年份:2016
- 资助金额:
$ 83.78万 - 项目类别:
Discovery Grants Program - Individual
Intelligent 3D world building from mobile terrestrial LiDAR point clouds
利用移动地面 LiDAR 点云构建智能 3D 世界
- 批准号:
311923-2013 - 财政年份:2015
- 资助金额:
$ 83.78万 - 项目类别:
Discovery Grants Program - Individual
Intelligent 3D world building from mobile terrestrial LiDAR point clouds
利用移动地面 LiDAR 点云构建智能 3D 世界
- 批准号:
311923-2013 - 财政年份:2014
- 资助金额:
$ 83.78万 - 项目类别:
Discovery Grants Program - Individual