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Analyzer-based Phase-Contrast Orthopedic Imaging

基于分析仪的相差骨科成像

基本信息

批准号：
10269477
负责人：
Jovan G Brankov
金额：
$ 14.15万
依托单位：
ILLINOIS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-15 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10269477
关键词：
Accident and Emergency department Acute Administrative Supplement American Arthralgia Bone Injury Businesses Caring Clinical Contrast Media Crystallization Development Diagnostic radiologic examination Elements Evaluation Future Goals Grant Illinois Image Imaging Device Imaging technology Industry Standard Injury Institutes Institutional Review Boards Joints Journals Laboratories Legal patent Ligaments Magnetic Resonance Imaging Mammographic screening Mediation Methods Modality Motivation Muscle Musculoskeletal Diseases Office Visits Operative Surgical Procedures Orthopedic Surgery Orthopedics Outpatients Output Patients Performance Phase Physicians Physics Primary Health Care Process Publications Radiation Dose Unit Reader Reporting Roentgen Rays Scanning Schedule Soft Tissue Injuries Specimen Structure Surgeon Synchrotrons System Technology Tendon structure Testing Thumb structure Time Tissue imaging Ultrasonography Visit Visualization Work X-Ray Computed Tomography base breast imaging clinical decision-making clinical development clinical imaging clinically significant contrast imaging cost design detector experimental study follow-up foot imaging modality imaging study imaging system improved in vivo parent grant programs prototype radiologist rapid diagnosis soft tissue urgent care

项目摘要

The proposed project concerns with evaluation of an analyzer-based phase contrast imaging (ABI), for orthopedic imaging. ABI is a modality that uses x-ray refraction to produce dramatic improvements in imaging of the soft tissues. ABI has been well documented to produce extraordinary images at synchrotron facilities. We have developed a breakthrough approach, now included into our full scale prototype that can deliver images under 10sec. This prototype is design for breast imaging. The goal of the proposed project supplement will be to evaluate its output in an expert reader study for orthopedic imaging application and also assess if the system cost can be reduced. ABI imaging offers many important potential benefits: 1) ABI has very high inherent soft- tissue image contrast due to the physics of x-ray refraction and strong scatter rejection, promising to provide clear visualization of bonnie structure as well as soft tissue which includes muscles, ligament and tendons; 2) currently ABI is a planar-imaging method like radiography, but can also be used in computed tomography (CT) modes; 3) ABI has no need for injected contrast agent; 4) ABI has potential to reduce radiation dose; 5) the image detail seen in ABI may ultimately eliminate the need follow CT or MRI imaging. The main elements in this supplement will define the project's specific aims as follows: 1. Evaluate existing imaging system using ex vivo foot and thumb specimens using expert orthopedic surgeons and radiologist. 2) Optimize system cost by evaluating if a smaller (therefore cheaper) detector and crystals can be used without performance reduction.

提议的项目涉及基于分析仪的相位差的评估

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Angular restriction fluorescence optical projection tomography to localize micrometastases in lymph nodes.

角度限制荧光光学投影断层扫描可定位淋巴结中的微转移。

DOI：
10.1117/1.jbo.24.11.110501
发表时间：
2019
期刊：
Journal of biomedical optics
影响因子：
3.5
作者：
Torres,VeronicaC;Li,Chengyue;He,Yusheng;Sinha,Lagnojita;Papavasiliou,Georgia;Sattar,HusainA;Brankov,JovanG;Tichauer,KennethM
通讯作者：
Tichauer,KennethM

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