Aeroallergens, Air Pollution and Respiratory Health in the Chickasaw Nation A1

契卡索族的空气过敏原、空气污染和呼吸系统健康 A1

• 批准号: 10239486
• 负责人: Amanda E Janitz
• 金额: $ 23.7万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10239486
• 关键词: Accounting; Address; Adult; Age; Air; Air Pollutants; Air Pollution; American Indians; Area; Asthma; Awareness; Biological; Chickasaw Nation; Chronic; Clinic Visits; Clinical; Colorado; Communities; Data; Devices; Diagnosis; Direct Costs; Educational Intervention; Environmental Risk Factor; Etiology; Exposure to; Facilities and Administrative Costs; Frequencies; Geographic Locations; Global Positioning System; Goals; Health; Health Promotion; High Prevalence; Hour; Household; Individual; Interview; Location; Lung diseases; Maps; Measures; Meteorology; Metered Dose Inhaler Device; Methods; Modeling; Monitor; Morbidity - disease rate; Neighborhoods; Nurses; Oklahoma; Outcome; Ozone; Participant; Particulate Matter; Patient Recruitments; Patients; Pollen; Population; Prevalence; Public Health; Reporting; Research; Research Personnel; Research Project Grants; Risk Factors; Role; Rural Population; Sampling; Series; Smoking; Societies; Source; Technology; Time; Tribes; United States Public Health Service; Universities; Urban Population; Visit; Work; airborne allergen; anthropogenesis; asthma exacerbation; asthma inhaler; base; college; cost; improved; land use; member; metropolitan; mortality; novel; pollutant; prevent; recruit; respiratory health; respiratory morbidity; rural Americans; tribal health; weather patterns

Project Summary/Abstract American Indians are disproportionately impacted by asthma. The Chickasaw Nation, located in southcentral Oklahoma, reports clinic visits for asthma as one of the top diagnoses, accounting for 7% of patients at Chickasaw Nation Department of Health. Due to the high patient burden for asthma in Chickasaw Nation, the Tribe has identified a need to better understand risk factors for asthma-related morbidity. The long-term goal of this research is to understand the impact of aeroallergens and anthropogenic air pollution on asthma morbidity in Chickasaw Nation and to investigate more efficient ways to monitor, control, and ultimately prevent asthma morbidity among this highly-susceptible population. The Chickasaw Nation provides clinical and public health services for the majority of American Indians residing within their jurisdictional area in southcentral Oklahoma; thus, improving the health of the Tribe promotes the health of the overall community. This study provides a unique opportunity to evaluate the effect of ambient aeroallergens (pollen) and anthropogenic air pollution (particulate matter, ozone) on asthma-related morbidity using a novel device to measure the time and location of metered-dose inhaler (MDI) use in a rural, American Indian population. This in-depth study will allow researchers and the Tribe to: 1) evaluate the association of spatially- and temporally-resolved aeroallergens and anthropogenic pollutants with Global Positioning System (GPS)-enabled MDIs among Chickasaw Nation community members with asthma, and 2) compare the participants' perceived individual and neighborhood asthma triggers to the spatial and temporal data collected through the MDIs using sketch maps and interviews. We are partnering with Propeller Health to use GPS-enabled MDIs to measure asthma exacerbations, which will allow us to collect the exact time and location of the MDI actuation. We will evaluate whether the measured exposures are associated with MDI actuation using a time-series model accounting for lag times up to one week. At the end of the study, the participants will develop sketch maps that describe the perceived geographic locations of their asthma triggers. Our central hypothesis is that aeroallergen and air pollution levels in Chickasaw Nation interact synergistically to increase the prevalence of asthma-related morbidity. Longitudinal data on aeroallergens and asthma are sparse in American Indian populations and awareness of triggers will help improve asthma management in Chickasaw Nation. This study provides a unique opportunity to evaluate the effect of aeroallergens and anthropogenic air pollution on asthma morbidity using a novel device to measure the time, frequency, and location of MDI use in this population.

项目摘要/摘要 美国印第安人受哮喘的影响不成比例。奇卡索国家，位于西南 俄克拉荷马州，报告哮喘的诊所就诊是最高诊断之一，占患者的7％ 奇卡索国家卫生部。由于奇卡索国家的哮喘患者负担很高， 部落已经确定有必要更好地了解与哮喘相关的发病率的风险因素。长期目标 这项研究是为了了解空气过敏原和人为空气污染对哮喘发病率的影响 在奇卡索国家 这个高度敏感的人群中的发病率。 Chickasaw Nation提供临床和公共卫生 居住在俄克拉荷马州中西部地区的大多数美洲印第安人的服务； 因此，改善部落的健康可以促进整个社区的健康。这项研究提供了 评估环境航空磨砂油（花粉）和人为空气污染的影响的独特机会 （颗粒物，臭氧）使用新型装置来测量时间和位置 在农村的印第安人人口中使用计量剂量吸入器（MDI）。这项深入的研究将允许 研究人员和部落至：1）评估空间和时间分辨的气溶胶和 具有全球定位系统（GPS）的MDI的人为污染物在Chickasaw Nation中 患有哮喘的社区成员，以及2）比较参与者的个人和社区 哮喘触发了使用Sketch Maps和访谈通过MDI收集的空间和时间数据。 我们正在与Propeller Health合作使用支持GPS的MDI来衡量哮喘病情，这将 允许我们收集MDI驱动的确切时间和位置。我们将评估是否测量 使用时间序列模型占滞后时间长达一周的时间序列模型与MDI致动。 在研究结束时，参与者将开发描述所感知地理的草图图 他们哮喘触发的位置。我们的中心假设是奇卡索（Chickasaw）的气雪剂和空气污染水平 国家协同互动以增加与哮喘相关的发病率的流行。纵向数据 美洲印第安人人口中的空气过敏原和哮喘稀疏，对触发因素的认识将有助于改善 卡索国家的哮喘管理。这项研究提供了一个独特的机会来评估 使用新型装置来测量时间，对哮喘发病率的空气过敏原和人为空气污染，以测量时间， MDI在该人群中使用的频率和位置。