Data Management and Bioinformatics Core

数据管理和生物信息学核心

基本信息

  • 批准号:
    10240685
  • 负责人:
  • 金额:
    $ 31.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-09-01 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

Summary The Data Management and Bioinformatics Core (DMBC) will support each of the Projects and the overall goals of the program by applying multiple types of computational analyses to determine the functional role of novel immune regulators. This work will include: (i) processing and performing bioinformatics analysis of the large- scale data sets generated within the Projects and Cores; (ii) identifying genes, proteins, epigenetic modifications and tissue phenotypes that are most affected by immune perturbations; and (iii) by integrating internally generated and publicly available data sets to identify relevant co-expression modules and infer key regulators underlying immune phenotypes. Fully exploiting high throughput technologies such as RNA-seq, ChIP-seq and ATAC-seq, as well as multi-parameter molecular phenotyping (CyTOF, MIBI, CODEX) requires significant infrastructure and sophisticated analysis methods. The DMBC has deep expertise in the analysis of data generated by these technologies and has developed computational tools to discover novel immune regulators and determine their mechanisms of action. Furthermore, the DMBC has necessary resources to manage and analyze these large data sets and disseminate them to the program investigators and to the public via websites and existing public databases. The Core has developed a proven model for the informatics core in which individual computational investigators are imbedded within each of the projects. The advantage of this structure is that the computational biologists can participate at every level of the experimental program. The Core has found this structure to be particularly effective given the broad range of approaches used disparate at the various centers (systems biology, genetics, multi-parameter signaling analysis).
总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ALAN A ADEREM其他文献

ALAN A ADEREM的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ALAN A ADEREM', 18)}}的其他基金

Project 1: Mechanisms of Disease Progression
项目1:疾病进展机制
  • 批准号:
    10339373
  • 财政年份:
    2018
  • 资助金额:
    $ 31.47万
  • 项目类别:
Adminstrative Core
行政核心
  • 批准号:
    10339370
  • 财政年份:
    2018
  • 资助金额:
    $ 31.47万
  • 项目类别:
Omics for TB: Response to Infection and Treatment
结核病组学:对感染和治疗的反应
  • 批准号:
    10339369
  • 财政年份:
    2018
  • 资助金额:
    $ 31.47万
  • 项目类别:
Omics for TB Disease Progression (OTB)
结核病进展组学 (OTB)
  • 批准号:
    9275342
  • 财政年份:
    2013
  • 资助金额:
    $ 31.47万
  • 项目类别:
Host Determinants of TB Disease Progression
结核病进展的宿主决定因素
  • 批准号:
    8577272
  • 财政年份:
    2013
  • 资助金额:
    $ 31.47万
  • 项目类别:
Technology Core
技术核心
  • 批准号:
    8577277
  • 财政年份:
    2013
  • 资助金额:
    $ 31.47万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8577275
  • 财政年份:
    2013
  • 资助金额:
    $ 31.47万
  • 项目类别:
Omics for TB Disease Progression (OTB)
结核病进展组学 (OTB)
  • 批准号:
    8686744
  • 财政年份:
    2013
  • 资助金额:
    $ 31.47万
  • 项目类别:
Omics for TB Disease Progression (OTB)
结核病进展组学 (OTB)
  • 批准号:
    8852535
  • 财政年份:
    2013
  • 资助金额:
    $ 31.47万
  • 项目类别:
Omics for TB Disease Progression (OTB)
结核病进展组学 (OTB)
  • 批准号:
    8564003
  • 财政年份:
    2013
  • 资助金额:
    $ 31.47万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 31.47万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了