Omics for TB: Response to Infection and Treatment

结核病组学:对感染和治疗的反应

基本信息

  • 批准号:
    10339369
  • 负责人:
  • 金额:
    $ 334.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-02-12 至 2024-01-31
  • 项目状态:
    已结题

项目摘要

Abstract – Overview With about 10 million new cases of active disease and 1.8 million deaths annually, TB is a global health emergency. A distinguishing feature of TB disease is its biological heterogeneity, which manifests at the clinical level chiefly in 2 forms: disease progression and treatment response. The premise of this Program is that the heterogeneous outcomes of TB infection and treatment are determined by the interplay of competing regulatory networks between the pathogen and the host. Our primary goal is to apply systems biology approaches to elucidate the biological control underlying the variability of disease outcome and response to treatment. Our first specific aim is to define novel host regulators of TB disease progression in vivo, and the innate and adaptive networks they control. We will also seek to define novel Mtb regulators of TB treatment response, and the Mtb regulatory networks that they control. This work will allow us to produce and validate host and Mtb models of TB disease progression and treatment response. Altogether, this program addresses key unanswered questions that stymie efforts to combat the TB pandemic. Our team has perfected the required platforms and scientific approaches to execute this ambitious research plan in a timely and cost- effective manner. All the participating investigators have strong records of interacting productively, and of disseminating their data and reagents to the scientific community.
摘要-概述

项目成果

期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Genetic Modification of Primary Human Myeloid Cells to Study Cell Migration, Activation, and Organelle Dynamics.
  • DOI:
    10.1002/cpz1.514
  • 发表时间:
    2022-08
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Greiner, Daniel;Scott, Tiana M;Olson, Gregory S;Aderem, Alan;Roh-Johnson, Minna;Johnson, Jarrod S
  • 通讯作者:
    Johnson, Jarrod S
Experimental and Computational Workflow for RNA Sequencing in Mycobacterium tuberculosis : From Total RNA to Differentially Expressed Genes.
结核分枝杆菌 RNA 测序的实验和计算工作流程:从总 RNA 到差异表达基因。
  • DOI:
    10.1007/978-1-0716-1460-0_21
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ma,Shuyi;JonesJr,RichardM;Gleason,NatalieS;Farrow-Johnson,Jessica;Sherman,DavidR
  • 通讯作者:
    Sherman,DavidR
The evolving biology of Mycobacterium tuberculosis drug resistance.
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ALAN A ADEREM其他文献

ALAN A ADEREM的其他文献

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{{ truncateString('ALAN A ADEREM', 18)}}的其他基金

Project 1: Mechanisms of Disease Progression
项目1:疾病进展机制
  • 批准号:
    10339373
  • 财政年份:
    2018
  • 资助金额:
    $ 334.54万
  • 项目类别:
Adminstrative Core
行政核心
  • 批准号:
    10339370
  • 财政年份:
    2018
  • 资助金额:
    $ 334.54万
  • 项目类别:
Omics for TB Disease Progression (OTB)
结核病进展组学 (OTB)
  • 批准号:
    9275342
  • 财政年份:
    2013
  • 资助金额:
    $ 334.54万
  • 项目类别:
Host Determinants of TB Disease Progression
结核病进展的宿主决定因素
  • 批准号:
    8577272
  • 财政年份:
    2013
  • 资助金额:
    $ 334.54万
  • 项目类别:
Technology Core
技术核心
  • 批准号:
    8577277
  • 财政年份:
    2013
  • 资助金额:
    $ 334.54万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8577275
  • 财政年份:
    2013
  • 资助金额:
    $ 334.54万
  • 项目类别:
Omics for TB Disease Progression (OTB)
结核病进展组学 (OTB)
  • 批准号:
    8686744
  • 财政年份:
    2013
  • 资助金额:
    $ 334.54万
  • 项目类别:
Omics for TB Disease Progression (OTB)
结核病进展组学 (OTB)
  • 批准号:
    8852535
  • 财政年份:
    2013
  • 资助金额:
    $ 334.54万
  • 项目类别:
Omics for TB Disease Progression (OTB)
结核病进展组学 (OTB)
  • 批准号:
    8564003
  • 财政年份:
    2013
  • 资助金额:
    $ 334.54万
  • 项目类别:
Data Management and Bioinformatics Core
数据管理和生物信息学核心
  • 批准号:
    10240685
  • 财政年份:
    2012
  • 资助金额:
    $ 334.54万
  • 项目类别:

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