Brain Banking Core

脑库核心

• 批准号: 10241893
• 负责人: Edward Byung-Ha Lee
• 金额: $ 105.34万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10241893
• 关键词: Acute; Address; Adherence; Alzheimer' s Disease; Archives; Autopsy; Brain; Brain Diseases; Brain Injuries; Censuses; Chronic; Clinical; Clinical Data; Communities; Consensus; Data; Data Set; Databases; Diagnostic; Ensure; Equipment and supply inventories; Evaluation; Exposure to; Histologic; Histology; Human; Image; Institution; International; Link; Long-Term Survivors; Military Personnel; Mission; Nerve Degeneration; Neuraxis; Neurodegenerative Disorders; Office of Administrative Management; Parkinson Disease; Patients; Prospective Studies; Protocols documentation; Recording of previous events; Research; Research Personnel; Research Project Grants; Research Support; Resources; Sampling; Scanning; Scotland; Secure; Site; Slide; Specimen; Sports; Stains; Tissue Donations; Tissue Sample; Tissues; Traumatic Brain Injury; Universities; brain research; brain tissue; central database; central nervous system injury; data management; design; digital; member; nervous system disorder; neuropathology; patient population; programs; repository; tissue archive; tissue resource

BRAIN BANK CORE SUMMARY Although we have made great progress in gaining a deeper understanding of traumatic brain injury (TBI) related neurodegeneration (TReND), we have not gotten to the point where appropriate thereapeutics are available. This is, in part, due to the limited number of suitable human brain tissue samples available to research institutions. In fact, there exists only one human brain tissue archive dedicated to TBI samples, located at the University of Glasgow in Scotland, UK. In order to overcome this lack of resource, the Brain Banking Core of CONNECT-TBI will bring together nine participating banks that will be capable of providing existing tissue samples from almost 2000 acute and over 800 chronic TBI cases. This Brain Banking Core will establish a unique and comprehensive central archive of all existing TBI related autopsy tissue, that will include a broad inventory of all available tissue and associated clinical data. The CONNECT-TBI Expert Consensus Group members will assess and score digitally scanned images. Within this Brain Banking Core will be high quality, robust clinical datasets and digitized histology sections that will not only support the Research Projects within this proposal, but support approved, external, researcher led studies. Furthermore, the BBC will establish a tissue donation network from all participating centers that will significantly enhance the number of available tissue samples. In all efforts, the Brain Banking Core will optimize best practice protocols and will ensure adherence to strict tissue handling, staining, and scanning protocols. Finally, the Brain Bank Core will facilitate the dissemination all TBI-related samples and data in support of the Research Projects which comprise the mission of CONNECT-TBI.

脑库核心 总结 虽然我们在更深入地了解创伤性脑损伤（TBI）方面取得了很大进展， 相关的神经变性（TReND），我们还没有达到适当的治疗方法 available.这部分是由于可用于研究的合适人脑组织样本数量有限。 研究机构事实上，只有一个专门用于TBI样本的人脑组织档案， 位于英国苏格兰的格拉斯哥大学。为了克服这种资源缺乏的问题， CONNECT-TBI的银行核心将汇集九家参与银行，这些银行将能够提供 现有的组织样本来自近2000例急性和800多例慢性TBI病例。这个大脑银行核心将 为所有现有的TBI相关尸检组织建立一个独特而全面的中央档案，其中将包括 所有可用组织和相关临床数据的广泛库存。CONNECT-TBI专家共识 小组成员将对数字扫描图像进行评估和评分。在这个大脑银行的核心将是高 高质量，强大的临床数据集和数字化组织学切片，不仅将支持研究项目 在本提案范围内，但支持经批准的外部研究人员领导的研究。此外，BBC将 在所有参与中心建立组织捐赠网络， 可用的组织样本在所有努力中，人才库核心将优化最佳实践协议，并将 确保遵守严格的组织处理、染色和扫描方案。最后，Brain Bank Core将 促进传播所有TBI相关样本和数据，以支持研究项目， 包括了CONNECT-TBI的使命。