Neuropathology Core

神经病理学核心

• 批准号: 10663874
• 负责人: Edward Byung-Ha Lee
• 金额: $ 17.71万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663874
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Amyloid beta-Protein; Archives; Autopsy; Basic Science; Biological; Blood Vessels; Brain; Cells; Central Nervous System; Cerebrovascular Disorders; Classification; Clinical; Cognitive; Collaborations; Complement; Data; Databases; Dedications; Dementia; Dementia with Lewy Bodies; Deposition; Diagnosis; Disease; Doctor of Medicine; Doctor of Philosophy; Documentation; Education; Elderly; Extracellular Space; Fostering; Freezing; Frontotemporal Dementia; Frontotemporal Lobar Degenerations; Goals; Heterogeneity; Histology; Histopathology; Human; Impaired cognition; Individual; Lesion; Lewy Bodies; Libraries; Literature; Magnetic Resonance Imaging; Mission; Monitor; Neurodegenerative Disorders; Neurofibrillary Tangles; Neuropil; Pathologic; Pathology; Peptides; Population; Qualifying; Research; Research Personnel; Research Support; Resolution; Sampling; Secure; Senile Plaques; Standardization; Tissue Banks; Work; aging brain; alpha synuclein; clinical phenotype; comorbidity; data management; demented; digital; education research; genetic analysis; genome-wide; hippocampal sclerosis; neuroimaging; neuropathology; nonalzheimer dementia; normal aging; protein TDP-43; protein aggregation; research study; synucleinopathy; tau Proteins; tissue fixing; transmission process

Neuropathology Core: Abstract Nearly all neurodegenerative disorders are characterized by progressive accumulations of pathological deposits of disease protein aggregates within cells, blood vessels or in the neuropil. These deposits are the signature CNS lesions that define these disorders as exemplified by the amyloid plaques and neurofibrillary tangles required for the postmortem diagnosis of Alzheimer's disease (AD) and related disorders (ADRD). However, Lewy bodies (LBs) and/or TDP-43 inclusions occur in ~70% of AD patients, as are other neuropathologies including aging related tau astrogliopathy (ARTAG), hippocampal sclerosis, and cerebrovascular disease. Other non-AD dementing illnesses are associated with a diverse spectrum of neuropathologic diagnoses including various α-synucleinopathies and frontotemporal lobar degeneration. A major focus of this NP Core is to define the full spectrum of co-morbid protein aggregate pathologies in the aging brain. A comprehensive post-mortem brain examination of individuals followed longitudinally in the Clinical Core provides definitive classification of the underlying neuropathology using standardized criteria in addition to the exhaustive documentation of co-morbid neurodegenerative disease pathologies in each case irrespective of clinical phenotype. Fixed and frozen tissues are banked and distributed to investigators to further both clinicopathologic and basic research studies on AD/ADRD. Neuropathology data is obtained in all cases which is transmitted to the National Alzheimer’s Coordinating Center in collaboration with the DMS Core. The NP Core also coordinates with the Neuroimaging Core to facilitate high resolution post-mortem MRI and to establish a digital histopathology library. The NP Core also provides advice and support to investigators including trainees supported by the Research Education Component to foster safe and informative human biosamples research. Thus, this NP Core is a vital component of the Penn ADRC in defining the complexity and breadth of neuropathologic change in ADRC subjects in support of its mission to increase research and education on AD/ADRD across the continuum from normal aging to dementia with the goal of identifying the causes of and cures for AD/ADRD.

神经病理学核心：摘要 几乎所有的神经退行性疾病的特征在于病理性神经退行性病变的进行性积累。 疾病蛋白质聚集体在细胞、血管或神经细胞中的沉积。这些存款是 特征性CNS病变定义了这些疾病，如淀粉样斑块和神经胶质瘤 阿尔茨海默病（AD）和相关疾病（ADRD）的尸检诊断所需的缠结。 然而，路易体（LB）和/或TDP-43包涵体发生在约70%的AD患者中，其他患者也是如此。 神经病理学，包括衰老相关的tau星形胶质细胞病（ARTAG）、海马硬化和 脑血管疾病其他非AD痴呆性疾病与多种多样的 神经病理学诊断包括各种α-突触核蛋白病和额颞叶变性。一 该NP核心的主要重点是定义在疾病中共病蛋白质聚集体病理的全谱。 老化的大脑对个体进行全面的死后脑部检查， 临床核心使用标准化标准提供了潜在神经病理学的明确分类， 除了每例病例中共病神经退行性疾病病理学的详尽记录外 与临床表型无关。固定和冷冻组织被储存并分发给研究者， 进一步开展AD/ADRD的临床病理和基础研究。神经病理学数据获得所有 这些病例将与DMS核心合作转交给国家阿尔茨海默氏症协调中心。 NP Core还与Neuroimaging Core协调，以促进高分辨率死后MRI， 建立数字化组织病理学图书馆。国家警察中心还向调查人员提供咨询和支持 包括由研究教育部分支持的受训人员，以培养安全和信息丰富的人类 生物样品研究。因此，这个NP Core是Penn ADRC定义复杂性的重要组成部分。 和广度的神经病理变化的ADRC科目，以支持其使命，以增加研究， 从正常衰老到痴呆的AD/ADRD教育，目的是确定 AD/ADRD的病因和治疗方法。