Neuropathology Core

神经病理学核心

• 批准号: 10264230
• 负责人: Edward Byung-Ha Lee
• 金额: $ 17.71万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264230
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease patient; Amyloid beta-Protein; Archives; Autopsy; Basic Science; Biological; Blood Vessels; Brain; Cells; Cerebrovascular Disorders; Classification; Clinical; Cognitive; Collaborations; Complement; Data; Databases; Dementia; Dementia with Lewy Bodies; Deposition; Diagnosis; Disease; Doctor of Medicine; Doctor of Philosophy; Documentation; Education; Elderly; Extracellular Space; Fostering; Freezing; Frontotemporal Dementia; Frontotemporal Lobar Degenerations; Goals; Heterogeneity; Histology; Histopathology; Human; Impaired cognition; Individual; Lesion; Lewy Bodies; Libraries; Literature; Magnetic Resonance Imaging; Mission; Monitor; Neuraxis; Neurodegenerative Disorders; Neurofibrillary Tangles; Neuropil; Pathologic; Pathology; Peptides; Population; Research; Research Personnel; Research Support; Resolution; Sampling; Secure; Senile Plaques; Standardization; Time; Tissue Banks; Tissues; Work; aging brain; alpha synuclein; clinical phenotype; comorbidity; data management; digital; education research; exhaustion; genetic analysis; genome-wide; hippocampal sclerosis; neuroimaging; neuropathology; nonalzheimer dementia; normal aging; protein TDP-43; protein aggregation; research study; synucleinopathy; tau Proteins

Neuropathology Core: Abstract Nearly all neurodegenerative disorders are characterized by progressive accumulations of pathological deposits of disease protein aggregates within cells, blood vessels or in the neuropil. These deposits are the signature CNS lesions that define these disorders as exemplified by the amyloid plaques and neurofibrillary tangles required for the postmortem diagnosis of Alzheimer's disease (AD) and related disorders (ADRD). However, Lewy bodies (LBs) and/or TDP-43 inclusions occur in ~70% of AD patients, as are other neuropathologies including aging related tau astrogliopathy (ARTAG), hippocampal sclerosis, and cerebrovascular disease. Other non-AD dementing illnesses are associated with a diverse spectrum of neuropathologic diagnoses including various α-synucleinopathies and frontotemporal lobar degeneration. A major focus of this NP Core is to define the full spectrum of co-morbid protein aggregate pathologies in the aging brain. A comprehensive post-mortem brain examination of individuals followed longitudinally in the Clinical Core provides definitive classification of the underlying neuropathology using standardized criteria in addition to the exhaustive documentation of co-morbid neurodegenerative disease pathologies in each case irrespective of clinical phenotype. Fixed and frozen tissues are banked and distributed to investigators to further both clinicopathologic and basic research studies on AD/ADRD. Neuropathology data is obtained in all cases which is transmitted to the National Alzheimer’s Coordinating Center in collaboration with the DMS Core. The NP Core also coordinates with the Neuroimaging Core to facilitate high resolution post-mortem MRI and to establish a digital histopathology library. The NP Core also provides advice and support to investigators including trainees supported by the Research Education Component to foster safe and informative human biosamples research. Thus, this NP Core is a vital component of the Penn ADRC in defining the complexity and breadth of neuropathologic change in ADRC subjects in support of its mission to increase research and education on AD/ADRD across the continuum from normal aging to dementia with the goal of identifying the causes of and cures for AD/ADRD.

神经病理学核心：摘要 几乎所有神经退行性疾病的特征都是进行性的病理性堆积。 细胞、血管或神经束内的疾病蛋白聚集体沉积。这些存款是 定义这些疾病的标志性中枢神经系统病变，如淀粉样斑块和神经纤维 死后诊断阿尔茨海默病(AD)和相关疾病(ADRD)所需的纠缠。 然而，约70%的AD患者会出现路易小体和/或TDP-43包涵体，其他患者也是如此 神经病理包括衰老相关的tau星形胶质病(ARTAG)、海马区硬化症和 脑血管疾病。其他非AD痴呆疾病与一系列不同的 神经病理诊断，包括各种α-突触核病和额颞叶变性。一个 这个NP核心的主要关注点是定义全谱的共病蛋白质聚集病理 大脑老化。对个体进行了全面的尸检，纵向观察了 临床核心使用标准化标准为潜在的神经病理学提供明确的分类 除了每个病例的共病神经退行性疾病病理的详尽记录外 与临床表型无关。固定和冷冻的组织被储存并分发给调查人员 进一步研究AD/ADRD的临床病理和基础研究。所有的神经病理数据都是 与DMS核心合作，将病例转送至国家阿尔茨海默氏症协调中心。 NP核心还与神经成像核心协调，以促进高分辨率尸检MRI和 建立数字组织病理学图书馆。NP Core还向调查人员提供建议和支持 包括由研究教育部分支持的受训人员，以培养安全和信息丰富的人 生物样本研究。因此，在定义复杂性方面，该NP核心是宾夕法尼亚ADRC的重要组成部分 ADRC受试者神经病理变化的广度和广度，以支持其增加研究和 从正常衰老到痴呆症的整个过程中关于AD/ADRD的教育，目的是确定 AD/ADRD的原因及治疗。