Vanderbilt Scholars in T4 Translational Research (V-STTaR) Program

范德比尔特 T4 转化研究学者 (V-STTaR) 计划

• 批准号: 10241357
• 负责人: SUNIL KRIPALANI
• 金额: $ 40.68万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10241357
• 关键词: Academic Medical Centers; Active Learning; Advisory Committees; Americas; Award; Blood; Cardiovascular system; Certification; Clinical; Clinical Research; Clinics and Hospitals; Development Plans; Doctor of Philosophy; Environment; Extramural Activities; Faculty; Fellowship; Funding; Goals; Grant; Health; Health Sciences; Heart; Heart Diseases; Hematological Disease; Hematology; Intervention; Journals; Laboratories; Lung; Lung diseases; Master of Public Health; Medicine; Mentors; Mentorship; Recording of previous events; Research; Research Project Grants; Resources; Scientist; Series; Site; Sleep; Sleep Disorders; Societies; Talents; Training; Translational Research; Translations; United States National Institutes of Health; career; career development; clinical center; community clinic; design; experience; faculty mentor; implementation research; implementation science; improved; medical schools; next generation; peer coaching; population health; programs; recruit

Project Summary Major gaps exist in the widespread implementation of proven clinical interventions into practice, which greatly limits the positive health impact of scientific discoveries. This new application seeks to establish the Vanderbilt Scholars in T4 Translational Research (V-STTaR) Program, to help train the next generation of implementation scientists to advance and improve population health in heart, lung, blood, and sleep (HLBS) disorders. We propose to support 5 faculty Scholars who have completed an MD or PhD in the health sciences at a level of 75% effort for 3 years, or until they successfully transition to an extramural award. Vanderbilt has an extremely strong environment and successful history of developing the careers of translational research scientists. A diverse pool of talented applicants is available through Vanderbilt's clinical/translational T32 grants; clinical/research fellowships in cardiovascular, pulmonary, hematology, and sleep medicine; the VA Quality Scholars Fellowship (eight national sites including one in Nashville); research partners including Meharry Medical College; and recruitment through national organizations. V-STTaR Scholars will have access to a cadre of well-established faculty mentors with sustained NIH funding and an extensive and successful track record of mentoring early career scholars. Each Scholar's Research Advisory Committee will draw from an experienced pool of 27 mentors in HLBS research and T4 translation, as well as 12 experts in real-world implementation (ImpleMentors). The program will have 3 major components: 1) advanced didactics, including a new Certificate in Implementation Science offered through the established Master of Public Health (MPH) program; 2) formal mentorship and career development activities designed to prepare Scholars for a competitive academic research career in HLBS T4 research; and 3) experiential learning through a closely- mentored implementation research project. Each Scholar will have an individualized development plan with milestones, tailored to their scientific background, training needs, and career goals. V-STTaR Scholars will have access to a diverse clinical laboratory for their implementation research projects through Vanderbilt University Medical Center and its partnerships across the Vanderbilt Health Affiliated Network, community clinics, and Hospital Corporation of America (HCA). Scholars will be supported by a broad array of institutional resources for career development, including the Center for Clinical Quality and Implementation Research scholarly series, journal clubs, work-in-progress sessions, clinical and translational research seminars through the Newman Society (a professional group for all career development awardees at Vanderbilt), and peer mentoring activities with other successful K awardees. Taken together, these resources provide an optimal environment for developing the next generation of independent scientists who conduct T4 translational research in HLBS disorders and close the gap between evidence and practice.

项目摘要 在将经证实的临床干预措施广泛付诸实践方面存在重大差距， 限制了科学发现对健康的积极影响。这项新的申请旨在建立范德比尔特 学者在T4转化研究（V-STTaR）计划，以帮助培养下一代的 实施科学家，以促进和改善人口健康的心脏，肺，血液和睡眠（HLBS） 紊乱我们建议支持5名在健康科学领域完成医学博士或博士学位的教师学者 在75%的努力水平为3年，或直到他们成功地过渡到校外奖。范德比尔特已经 一个非常强大的环境和发展转化研究事业的成功历史 科学家通过范德比尔特的临床/翻译T32，可以获得各种有才华的申请人 赠款;心血管、肺、血液学和睡眠医学的临床/研究奖学金;退伍军人事务部 优质学者奖学金（八个国家站点，包括纳什维尔的一个站点）;研究伙伴包括 Meharry医学院;以及通过国家组织征聘。V-STTaR学者将获得 到一个有着持续的NIH资金和广泛而成功的 指导早期职业学者的记录。每个学者的研究咨询委员会将从 27位在HLBS研究和T4翻译方面经验丰富的导师，以及12位现实世界的专家 实施（ImpleMentors）。该计划将有3个主要组成部分：1）先进的教学法，包括一个 通过公共卫生硕士（MPH）提供的实施科学新证书 计划; 2）正式的导师和职业发展活动，旨在为学者准备一个 在HLBS T4研究中竞争激烈的学术研究生涯;以及3）通过紧密的 指导实施研究项目。每个学者将有一个个性化的发展计划， 里程碑，根据他们的科学背景，培训需求和职业目标量身定制。V-STTaR学者将 可以通过范德比尔特获得多样化的临床实验室来实施研究项目 大学医学中心及其在范德比尔特健康附属网络，社区的合作伙伴关系 美国医院公司（HCA）学者将得到广泛的机构支持， 职业发展资源，包括临床质量和实施研究中心 学术系列，期刊俱乐部，工作进展会议，临床和转化研究研讨会，通过 纽曼协会（一个面向范德比尔特所有职业发展获奖者的专业团体）和同行 与其他成功的K获奖者进行指导活动。综合起来，这些资源提供了 培养下一代独立科学家的环境， 研究HLBS疾病，缩小证据与实践之间的差距。

项目成果

Investigating N-3 Fatty Acids to prevent Neonatal Tobacco-related outcomeS (INFANTS): study protocol for a double-blind, randomized, placebo-controlled parallel clinical trial of n-3 polyunsaturated fatty acids in pregnant smokers.

• DOI: 10.1186/s13063-021-05865-7
• 发表时间: 2021-12-14
• 期刊: Trials
• 影响因子: 2.5
• 作者: Murff HJ;Greevy RA;Sanghani RS;Hartmann KE;Hartert TV;Graves CR;Lee SS;Tindle HA
• 通讯作者: Tindle HA

An International Study Exploring the Experience of Survivors of Critical Illness as Volunteers Within ICU Recovery Services.

• DOI: 10.1097/cce.0000000000000273
• 发表时间: 2020-11-01
• 期刊: Critical care explorations
• 作者: Robinson, Carly;Hibbert, Elizabeth;Boehm, Leanne M
• 通讯作者: Boehm, Leanne M

Cigarette Smoking and Risk Perceptions During the COVID-19 Pandemic Reported by Recently Hospitalized Participants in a Smoking Cessation Trial.

• DOI: 10.1007/s11606-021-06913-3
• 发表时间: 2021-12
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Rigotti NA;Chang Y;Regan S;Lee S;Kelley JHK;Davis E;Levy DE;Singer DE;Tindle HA
• 通讯作者: Tindle HA

Breaking the Mold: Safely Delabeling Penicillin Allergies in Hospitalized Children.

• DOI: 10.1542/hpeds.2020-005280
• 发表时间: 2021-05-01
• 期刊: Hospital pediatrics
• 作者: Antoon, James W;Grisso, Alison G;Stone, Cosby A
• 通讯作者: Stone, Cosby A

Key Components of ICU Recovery Programs: What Did Patients Report Provided Benefit?

• DOI: 10.1097/cce.0000000000000088
• 发表时间: 2020-04-01
• 期刊: Critical care explorations
• 作者: McPeake, Joanne;Boehm, Leanne M;Sevin, Carla M
• 通讯作者: Sevin, Carla M