Elicitation of α4β7-Competitive Antibodies in Rhesus Macaques by a Synthetic V2 Immunogen

合成 V2 免疫原在恒河猴中诱导 α4β7 竞争性抗体

• 批准号: 10251827
• 负责人: Ronald S. Veazey
• 金额: $ 6.79万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10251827
• 关键词: AIDS Vaccines; Advanced Development; Animals; Antibodies; Antibody Response; Antigens; Award; Clinical; Complement; Contracts; Development; Evaluation Studies; Funding; Grant; HIV vaccine; Immune response; Immunization; Immunize; Immunotherapy; Investigator-Initiated Research; Local Microbicides; Macaca mulatta; Modality; Mucous Membrane; National Institute of Allergy and Infectious Disease; Pathogenicity; Prevention; Prevention strategy; Research Design; Research Personnel; Research Project Grants; Resources; SIV; Vaccine Research; Vaccines; Virus; immunogenicity; nonhuman primate; pre-clinical; preclinical evaluation; preclinical study; programs; vaccine candidate; vaccine development; vaccine evaluation

The development of HIV vaccines and other prevention strategies relies on the use of nonhuman primates in preclinical studies to advance the development of effective AIDS vaccine candidates and to advance development of effective topical microbicides and other prevention modalities or immune-based therapies. The NIAID Simian Vaccine Evaluation Unit (SVEU) contracts shall provide nonhuman primate resources that primarily support preclinical evaluation of AIDS vaccines. The SVEUs conduct studies in support of vaccines being developed by a wide range of investigators. These studies complement NIAID-supported basic vaccine research and vaccine evaluation studies funded through R01 (investigator-initiated research) grants, HIVRAD (HIV Vaccine Research and Design Program) grants, IPCAVD (Integrated Preclinical-Clinical AIDS Vaccine Development) grants, and NHP Consortium awards. The SVEUs also perform studies of candidate vaccines offered by companies or other researchers. The primary activity is to conduct a study to elicit α4β7- competitive antibodies in non-human primates.

HIV疫苗和其他预防策略的开发依赖于在临床前研究中使用非人灵长类动物来推进有效的艾滋病候选疫苗的开发，并促进有效的局部杀微生物剂和其他预防方式或基于免疫的疗法的开发。 NIAID 猿猴疫苗评估单位 (SVEU) 合同应提供主要支持艾滋病疫苗临床前评估的非人类灵长类动物资源。 SVEU 开展研究以支持广泛的研究人员正在开发的疫苗。这些研究补充了 NIAID 支持的基础疫苗研究和疫苗评估研究，这些研究通过 R01（研究者发起的研究）拨款、HIVRAD（艾滋病毒疫苗研究和设计计划）拨款、IPCAVD（临床前-临床综合艾滋病疫苗开发）拨款和 NHP 联盟奖项资助。 SVEU 还对公司或其他研究人员提供的候选疫苗进行研究。 主要活动是进行一项研究，以在非人类灵长类动物中引发 α4β7 竞争性抗体。