Nonhuman Primate Core

非人类灵长类核心

• 批准号: 9100629
• 负责人: Ronald S. Veazey
• 金额: $ 24.72万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9100629
• 关键词: Acquired Immunodeficiency Syndrome; Animal Experimentation; Animal Husbandry; Animal Model; Animal Welfare; Animals; Clinical; Clinical Management; Collaborations; Confocal Microscopy; Development; Experimental Designs; Fostering; Funding; Goals; Grant; HIV; Housing; Human; Human Resources; Image Analysis; Immunohistochemistry; In Situ Hybridization; In Vitro; Individual; Instruction; Investigation; Joints; Laboratories; Laboratory Procedures; Lead; Leadership; Link; Mentors; Mentorship; Mission; Modeling; Performance; Phase; Pilot Projects; Play; Postdoctoral Fellow; Primates; Procedures; Process; Publications; Research; Research Infrastructure; Research Personnel; Resources; Role; Running; SIV; Series; Services; Site; Strategic Planning; Students; Technical Expertise; Training; Training and Education; Translating; Translations; United States National Institutes of Health; Videoconferences; Videoconferencing; Work; base; clinical care; design; in vivo; member; microscopic imaging; nonhuman primate; programs; symposium; working group

PROJECT SUMMARY (See instructions); The mission ofthe Nonhuman Primate (NHP) Core (Core H), located at the Tulane National Primate Research Center (TNPRC), is to provide to Penn CFAR investigators highly integrated clinical and laboratory resources and expertise in using NHP models relevant to AIDS. The Core is lead by Andrew Lackner with Preston Marx, Ronald Veazey, and Marcelo Kuroda as additional key personnel. Core H adds value to the CFAR by enhancing and facilitating the ability of CFAR investigators to perform HIV/SIV-related studies in NHPs, providing mentorship and on-site training to junior investigators, and promoting scientific collaborations between the TNPRC and CFAR investigators. Specific goals are to (1) provide oversight and assistance in all phases of research using NHPs, supporting CFAR investigator projects and proposals and providing resources, assistance with experimental design, and compliance with all animal welfare and biosafety requirements; (2) provide housing, clinical care, animal husbandry, and other routine and necessary services for NHPs assigned to CFAR projects; (3) provide technical expertise and laboratory support for studies utilizing NHPs; (4) support a NHP Pilot Grants Program (separate from but complementary to the Developmental Pilot Program run by Core B) designed to encourage junior and new investigators to use NHP models; (5) provide education, training and mentoring to junior and new investigators who have not previously worked with NHP; and (6) stimulate and facilitate translation of bench-based findings to NHP experimentation. Collaborations between Core H and the CFAR are facilitated by jointly sponsored symposia focused on NHP HIV/SIV research and a seminar series integrated with TNPRC via video-conference links. Core H includes specialized clinical, laboratory and consultative components. The Core performs a variety of specialized services including in situ hybridization, immunohistochemistry, confocal microscopy and image analysis. Core H also participates in the CFAR's mentoring mission by training and educating CFAR members and their students and postdocs on use of NHP models. Core performance is evaluated as part ofthe CFAR's annual strategic planning process. Core H will also play an active role in working with the CFAR's newly formed scientific working groups. In the current cycle Core H has supported 12 NHP Pilot Projects, closely worked with 20 CFAR investigators, provided onsite training for 6 students and/or post docs, and contributed to 20 publications, and 8 NIH grants.

项目摘要（参见说明）； 非人类灵长类动物 (NHP) 核心（核心 H）位于杜兰国家灵长类动物研究中心 (TNPRC)，其使命是向宾夕法尼亚大学 CFAR 研究人员提供高度集成的临床和实验室资源以及使用与艾滋病相关的 NHP 模型的专业知识。该核心由 Andrew Lackner 领导，其他关键人员包括 Preston Marx、Ronald Veazey 和 Marcelo Kuroda。核心 H 通过增强和促进 CFAR 研究人员在 NHP 中进行 HIV/SIV 相关研究的能力、为初级研究人员提供指导和现场培训以及促进 TNPRC 和 CFAR 研究人员之间的科学合作，为 CFAR 增加价值。具体目标是 (1) 在使用 NHP 的研究的所有阶段提供监督和协助，支持 CFAR 研究者项目和提案，并提供资源、协助实验设计以及遵守所有动物福利和生物安全要求； (2) 为参与 CFAR 项目的 NHP 提供住房、临床护理、畜牧以及其他日常和必要的服务； (3) 为利用 NHP 的研究提供技术专业知识和实验室支持； (4) 支持 NHP 试点资助计划（与核心 B 运行的发展试点计划分开但互补），旨在鼓励初级和新研究者使用 NHP 模型； (5) 为以前没有在 NHP 工作过的初级和新研究者提供教育、培训和指导； (6) 刺激并促进基于实验室的发现转化为 NHP 实验。联合主办的以 NHP HIV/SIV 研究为重点的研讨会以及通过视频会议链接与 TNPRC 整合的研讨会系列促进了 Core H 和 CFAR 之间的合作。核心 H 包括专门的临床、实验室和咨询部分。该核心提供各种专业服务，包括原位杂交、免疫组织化学、共聚焦显微镜和图像分析。 Core H 还通过培训和教育 CFAR 成员及其学生和博士后使用 NHP 模型来参与 CFAR 的指导任务。核心绩效评估是 CFAR 年度战略规划流程的一部分。 Core H 还将在与 CFAR 新成立的科学工作组的合作中发挥积极作用。在当前周期中，Core H 支持了 12 个 NHP 试点项目，与 20 名 CFAR 研究人员密切合作，为 6 名学生和/或博士后提供了现场培训，并为 20 篇出版物和 8 项 NIH 拨款做出了贡献。