Nonhuman Primate Core

项目总结(见说明)； 位于杜兰国家灵长类研究中心(TNPRC)的非人灵长类(NHP)核心(核心H)的使命是为宾夕法尼亚大学CFAR研究人员提供高度整合的临床和实验室资源以及使用与艾滋病相关的NHP模型的专业知识。核心由安德鲁·拉克纳领导，普雷斯顿·马克思、罗纳德·维齐和马塞洛·黑田东彦作为额外的关键人员。核心H增加了CFAR的价值，方法是加强和促进CFAR调查员在国家卫生计划中进行艾滋病毒/SIV相关研究的能力，为初级调查员提供指导和现场培训，并促进TNPRC和CFAR调查员之间的科学合作。具体目标是：(1)在使用NHP的研究的所有阶段提供监督和援助，支持CFAR调查员项目和建议，并提供资源，协助实验设计，并遵守所有动物福利和生物安全要求；(2)为分配给CFAR项目的NHP提供住房、临床护理、畜牧和其他常规和必要的服务；(3)为利用NHP的研究提供技术专业知识和实验室支持；(4)支持旨在鼓励初级和新手研究人员使用NHP模型的NHP试点补助金计划(独立于核心B运行的开发试点计划，但对其是补充)；(5)向以前没有与国家核计划合作过的初级和新手调查人员提供教育、培训和指导；以及(6)鼓励和促进将基于实验台的研究结果转化为国家核计划实验。通过共同赞助以NHP艾滋病毒/SIV研究为重点的研讨会和通过视频会议链接与TNPRC整合的一系列研讨会，促进了核心H和CFAR之间的合作。核心H包括专门的临床、实验室和咨询部分。该中心提供各种专业服务，包括原位杂交、免疫组织化学、共聚焦显微镜和图像分析。CORE H还参与CFAR的指导任务，培训和教育CFAR成员及其学生和博士后使用NHP模式。核心绩效作为CFAR年度战略规划过程的一部分进行评估。CORE H还将在与CFAR新成立的科学工作组合作方面发挥积极作用。在本周期内，Core H支持了12个NHP试点项目，与20名CFAR调查人员密切合作，为6名学生和/或博士后提供了现场培训，并为20份出版物和8份国家卫生研究院赠款做出了贡献。

PROJECT SUMMARY (See instructions); The mission ofthe Nonhuman Primate (NHP) Core (Core H), located at the Tulane National Primate Research Center (TNPRC), is to provide to Penn CFAR investigators highly integrated clinical and laboratory resources and expertise in using NHP models relevant to AIDS. The Core is lead by Andrew Lackner with Preston Marx, Ronald Veazey, and Marcelo Kuroda as additional key personnel. Core H adds value to the CFAR by enhancing and facilitating the ability of CFAR investigators to perform HIV/SIV-related studies in NHPs, providing mentorship and on-site training to junior investigators, and promoting scientific collaborations between the TNPRC and CFAR investigators. Specific goals are to (1) provide oversight and assistance in all phases of research using NHPs, supporting CFAR investigator projects and proposals and providing resources, assistance with experimental design, and compliance with all animal welfare and biosafety requirements; (2) provide housing, clinical care, animal husbandry, and other routine and necessary services for NHPs assigned to CFAR projects; (3) provide technical expertise and laboratory support for studies utilizing NHPs; (4) support a NHP Pilot Grants Program (separate from but complementary to the Developmental Pilot Program run by Core B) designed to encourage junior and new investigators to use NHP models; (5) provide education, training and mentoring to junior and new investigators who have not previously worked with NHP; and (6) stimulate and facilitate translation of bench-based findings to NHP experimentation. Collaborations between Core H and the CFAR are facilitated by jointly sponsored symposia focused on NHP HIV/SIV research and a seminar series integrated with TNPRC via video-conference links. Core H includes specialized clinical, laboratory and consultative components. The Core performs a variety of specialized services including in situ hybridization, immunohistochemistry, confocal microscopy and image analysis. Core H also participates in the CFAR's mentoring mission by training and educating CFAR members and their students and postdocs on use of NHP models. Core performance is evaluated as part ofthe CFAR's annual strategic planning process. Core H will also play an active role in working with the CFAR's newly formed scientific working groups. In the current cycle Core H has supported 12 NHP Pilot Projects, closely worked with 20 CFAR investigators, provided onsite training for 6 students and/or post docs, and contributed to 20 publications, and 8 NIH grants.