NIA Interlab: Targeting the Mechanism in Type 2 Diabetes

点击翻译按钮获取中文摘要

Werner syndrome is a premature aging disorder characterized by graying and loss of hair, cataracts, short stature, skin ulcers, type-2 diabetes, myocardial infarction, atherosclerosis, and malignancy. More than half of Werner syndrome patients get diabetes. However, there is limited understanding of the mechanism involved in Werner syndrome-associated diabetes. This lack of information makes it difficult to target treatment for diabetes in WS patients. In the current project, we will be investigating the role of insulin signaling in Wrn-deficient mice, C.elegans and cell line models. We will perform analyses to determine the metabolic deregulation in Wrn-deficient model systems. The proposed investigation will provide critical insight towards understanding the molecular pathogenesis associated with type-2 diabetes in WS patients. This study is of clinical relevance and upon successful completion we hope will provide therapeutic strategies to target diabetes in WS patients.