Cancer Cell Networks Scientific Program

癌细胞网络科学计划

• 批准号: 10260735
• 负责人: MELANIE H. COBB
• 金额: $ 3.5万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-03 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260735
• 关键词: Acute; Animal Model; Atmosphere; Basic Science; Behavior; Biological Models; Bypass; Cancer Center; Cancer Center Support Grant; Cataloging; Catalogs; Cell model; Cells; Chemistry; Clinical; Collaborations; Communication; Cues; Data; Dependence; Development; Diagnostic; Disease; Doctor of Philosophy; Emerging Technologies; Environment; Fostering; Funding; Generations; Genetic; Goals; Human; In Vitro; Institutes; Investigation; Investigational Therapies; Knowledge; Laboratories; Leadership; Malignant Neoplasms; Medical; Medical center; Molecular; NCI-Designated Cancer Center; Pathway interactions; Patients; Peer Review; Property; Publications; Research; Research Design; Research Institute; Research Personnel; Resolution; Resource Sharing; Sampling; Scientist; Testing; Texas; United States National Academy of Sciences; Validation; cancer cell; cancer prevention; cell behavior; cell growth; cell transformation; high throughput screening; human disease; in vivo; inter-institutional; lung small cell carcinoma; member; programs; recruit; restraint; small molecule; structural biology; success; support network; synergism; therapeutic evaluation; therapeutic target; tumorigenesis; tumorigenic

Harold C. Simmons Cancer Center Cancer Cell Networks Scientific Program Project Summary/Abstract The focus of the Cancer Cell Networks Program is to promote investigation that will lead to a mechanistic understanding of aberrant cell regulatory networks supporting tumorigenesis. Approaches range from structural biology to animal models, and much in between. To promote cancer relevance and synergy across Simmons Cancer Center efforts, our scientific goals are broad and remain much the same as in the last submission: Goal 1) Define the mechanisms and pathways that integrate external and internal regulatory cues at the cell autonomous level. Goal 2) Establish how aberrant cell regulatory behavior contributes to cell transformation and tumorigenesis. Goal 3) Facilitate interactions with translational and clinical scientists to test the therapeutic benefit of modulating cell regulatory components. As of 2012, the Cancer Cell Networks Program is co-led by Melanie Cobb, PhD, and James Brugarolas, MD, PhD. The program has grown; it now has 46 members in 17 departments and centers. Five members are Howard Hughes Medical Institute investigators; five, including the program leader, have been elected to the National Academy of Sciences; and one is a Nobel laureate. The investigators in the CCN Program are currently supported by $33.1 million in peer-reviewed funding with $5.0 million from the NCI and $11 million from the Cancer Prevention and Research Institute of Texas (CPRIT). Through a combination of member recruiting and programmatic interactions, the CCN has had much success in engaging the discovery power of UTSW investigators for the development of new cancer focused research initiatives. Since 2009 the members of the CCN Program have authored a total of 382 publications, with 14% of them being intra-programmatic, 34% being inter-programmatic, and 23% inter-institutional with authors from other NCI-designated cancer centers.

Harold C.西蒙斯癌症中心 癌细胞网络科学计划 项目总结/摘要 癌症细胞网络计划的重点是促进调查，这将导致一个机制， 理解支持肿瘤发生的异常细胞调控网络。方法从结构 从生物学到动物模型，以及介于两者之间的许多东西。促进癌症相关性和西蒙斯的协同作用 癌症中心的努力，我们的科学目标是广泛的，并保持与上次提交的大致相同： 目标1）定义在细胞中整合外部和内部调节线索的机制和途径 自主水平。 目标2）确定异常的细胞调节行为如何促进细胞转化和肿瘤发生。 目标3）促进与转化和临床科学家的互动，以测试 调节细胞调节成分。 截至2012年，癌细胞网络计划由Melanie Cobb博士和James Brugarolas博士共同领导， PhD.该方案已经扩大，现在有17个部门和中心的46名成员。五名成员是 霍华德休斯医学研究所的研究人员;包括项目负责人在内的五名研究人员已当选为 国家科学院;一个是诺贝尔奖得主。 CCN计划的研究人员目前获得了3310万美元的同行评审资金支持， 500万美元来自NCI，1100万美元来自德克萨斯州癌症预防和研究所 （CPRIT）。通过会员招募和项目互动的结合，CCN已经有了很多 成功地利用UTSW研究人员的发现能力，开发新的癌症， 研究倡议。自2009年以来，CCN计划的成员共撰写了382篇出版物， 其中14%是计划内的，34%是计划间的，23%是机构间的， 作者来自其他NCI-designated癌症中心。