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Cancer Cell Networks Scientific Program

癌细胞网络科学计划

基本信息

批准号：
10260735
负责人：
MELANIE H. COBB
金额：
$ 3.5万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-03 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10260735
关键词：
Acute Animal Model Atmosphere Basic Science Behavior Biological Models Bypass Cancer Center Cancer Center Support Grant Cataloging Catalogs Cell model Cells Chemistry Clinical Collaborations Communication Cues Data Dependence Development Diagnostic Disease Doctor of Philosophy Emerging Technologies Environment Fostering Funding Generations Genetic Goals Human In Vitro Institutes Investigation Investigational Therapies Knowledge Laboratories Leadership Malignant Neoplasms Medical Medical center Molecular NCI-Designated Cancer Center Pathway interactions Patients Peer Review Property Publications Research Research Design Research Institute Research Personnel Resolution Resource Sharing Sampling Scientist Testing Texas United States National Academy of Sciences Validation cancer cell cancer prevention cell behavior cell growth cell transformation high throughput screening human disease in vivo inter-institutional lung small cell carcinoma member programs recruit restraint small molecule structural biology success support network synergism therapeutic evaluation therapeutic target tumorigenesis tumorigenic

项目摘要

Harold C. Simmons Cancer Center Cancer Cell Networks Scientific Program Project Summary/Abstract The focus of the Cancer Cell Networks Program is to promote investigation that will lead to a mechanistic understanding of aberrant cell regulatory networks supporting tumorigenesis. Approaches range from structural biology to animal models, and much in between. To promote cancer relevance and synergy across Simmons Cancer Center efforts, our scientific goals are broad and remain much the same as in the last submission: Goal 1) Define the mechanisms and pathways that integrate external and internal regulatory cues at the cell autonomous level. Goal 2) Establish how aberrant cell regulatory behavior contributes to cell transformation and tumorigenesis. Goal 3) Facilitate interactions with translational and clinical scientists to test the therapeutic benefit of modulating cell regulatory components. As of 2012, the Cancer Cell Networks Program is co-led by Melanie Cobb, PhD, and James Brugarolas, MD, PhD. The program has grown; it now has 46 members in 17 departments and centers. Five members are Howard Hughes Medical Institute investigators; five, including the program leader, have been elected to the National Academy of Sciences; and one is a Nobel laureate. The investigators in the CCN Program are currently supported by $33.1 million in peer-reviewed funding with $5.0 million from the NCI and $11 million from the Cancer Prevention and Research Institute of Texas (CPRIT). Through a combination of member recruiting and programmatic interactions, the CCN has had much success in engaging the discovery power of UTSW investigators for the development of new cancer focused research initiatives. Since 2009 the members of the CCN Program have authored a total of 382 publications, with 14% of them being intra-programmatic, 34% being inter-programmatic, and 23% inter-institutional with authors from other NCI-designated cancer centers.

Harold C. Simmons癌症中心