Cancer Cell Networks Scientific Program

癌细胞网络科学计划

• 批准号: 10260735
• 负责人: MELANIE H. COBB
• 金额: $ 3.5万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-03 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260735
• 关键词: Acute; Animal Model; Atmosphere; Basic Science; Behavior; Biological Models; Bypass; Cancer Center; Cancer Center Support Grant; Cataloging; Catalogs; Cell model; Cells; Chemistry; Clinical; Collaborations; Communication; Cues; Data; Dependence; Development; Diagnostic; Disease; Doctor of Philosophy; Emerging Technologies; Environment; Fostering; Funding; Generations; Genetic; Goals; Human; In Vitro; Institutes; Investigation; Investigational Therapies; Knowledge; Laboratories; Leadership; Malignant Neoplasms; Medical; Medical center; Molecular; NCI-Designated Cancer Center; Pathway interactions; Patients; Peer Review; Property; Publications; Research; Research Design; Research Institute; Research Personnel; Resolution; Resource Sharing; Sampling; Scientist; Testing; Texas; United States National Academy of Sciences; Validation; cancer cell; cancer prevention; cell behavior; cell growth; cell transformation; high throughput screening; human disease; in vivo; inter-institutional; lung small cell carcinoma; member; programs; recruit; restraint; small molecule; structural biology; success; support network; synergism; therapeutic evaluation; therapeutic target; tumorigenesis; tumorigenic

Harold C. Simmons Cancer Center Cancer Cell Networks Scientific Program Project Summary/Abstract The focus of the Cancer Cell Networks Program is to promote investigation that will lead to a mechanistic understanding of aberrant cell regulatory networks supporting tumorigenesis. Approaches range from structural biology to animal models, and much in between. To promote cancer relevance and synergy across Simmons Cancer Center efforts, our scientific goals are broad and remain much the same as in the last submission: Goal 1) Define the mechanisms and pathways that integrate external and internal regulatory cues at the cell autonomous level. Goal 2) Establish how aberrant cell regulatory behavior contributes to cell transformation and tumorigenesis. Goal 3) Facilitate interactions with translational and clinical scientists to test the therapeutic benefit of modulating cell regulatory components. As of 2012, the Cancer Cell Networks Program is co-led by Melanie Cobb, PhD, and James Brugarolas, MD, PhD. The program has grown; it now has 46 members in 17 departments and centers. Five members are Howard Hughes Medical Institute investigators; five, including the program leader, have been elected to the National Academy of Sciences; and one is a Nobel laureate. The investigators in the CCN Program are currently supported by $33.1 million in peer-reviewed funding with $5.0 million from the NCI and $11 million from the Cancer Prevention and Research Institute of Texas (CPRIT). Through a combination of member recruiting and programmatic interactions, the CCN has had much success in engaging the discovery power of UTSW investigators for the development of new cancer focused research initiatives. Since 2009 the members of the CCN Program have authored a total of 382 publications, with 14% of them being intra-programmatic, 34% being inter-programmatic, and 23% inter-institutional with authors from other NCI-designated cancer centers.

Harold C. Simmons癌症中心 癌细胞网络科学计划 项目摘要/摘要 癌细胞网络计划的重点是促进研究，这将导致机械 了解支持肿瘤发生的异常细胞调节网络。方法范围从结构性 动物模型的生物学，介于两者之间。促进跨西蒙斯的癌症相关性和协同作用 癌症中心的努力，我们的科学目标是广泛的，并且与上次提交中的相同： 目标1）定义整合细胞外部和内部调节线索的机制和途径 自主级别。 目标2）确定异常细胞调节行为如何有助于细胞转化和肿瘤发生。 目标3）促进与转化和临床科学家的相互作用，以测试 调节细胞调节组件。 截至2012年，癌细胞网络计划由Melanie Cobb博士和医学博士James Brugarolas共同领导 博士学位。该计划已经成长；现在，它在17个部门和中心拥有46名成员。五个成员是 霍华德·休斯医学院的调查人员；包括计划负责人在内的五人已当选为 国家科学院；一个是诺贝尔奖获得者。 CCN计划中的调查人员目前得到了3,310万美元的同行评审资金的支持 来自NCI的500万美元，得克萨斯州癌症预防和研究所的1100万美元 （CPRIT）。通过成员招聘和编程互动的结合，CCN有很多 成功地吸引UTSW调查人员的发现能力以发展为以新癌症为中心 研究计划。自2009年以来，CCN计划的成员总共撰写了382个出版物， 其中有14％是程序内部的，34％是截面的，23％的机构间 来自其他NCI指定的癌症中心的作者。