Cancer Cell Networks Scientific Program

哈罗德·西蒙斯癌症中心 癌细胞网络科学计划 项目摘要/摘要 癌细胞网络计划的重点是促进研究，这将导致一种机械化的 对支持肿瘤发生的异常细胞调控网络的理解。方法范围从结构性的 从生物学到动物模型，还有很多介于两者之间的东西。促进西蒙斯与癌症的相关性和协同性 癌症中心的努力，我们的科学目标是广泛的，并与上一次提交的大致相同： 目标1)定义在细胞中整合外部和内部调节信号的机制和途径 自治级别。 目标2)确定异常的细胞调节行为如何有助于细胞转化和肿瘤的发生。 目标3)促进与翻译和临床科学家的互动，以测试 调节细胞调节成分。 截至2012年，癌症细胞网络计划由Melanie Cobb博士和James Brugarolas医学博士共同领导， 博士学位。该项目的规模已经扩大；它现在有46名成员，分布在17个部门和中心。五名成员是 霍华德·休斯医学研究所的调查人员；包括项目负责人在内的五人已当选为 其中一位是诺贝尔奖获得者。 CCN计划的调查人员目前得到了3310万美元的同行审查资金支持， 来自NCI的500万美元和德克萨斯州癌症预防和研究所的1100万美元 (CPRIT)。通过成员招募和方案互动的结合，CCN已经有了很多 成功利用UTSW调查人员的发现能力开发新的癌症焦点 研究计划。自2009年以来，CCN计划的成员共撰写了382份出版物， 其中14%是方案内的，34%是方案间的，23%是机构间的 来自NCI指定的其他癌症中心的作者。

Harold C. Simmons Cancer Center Cancer Cell Networks Scientific Program Project Summary/Abstract The focus of the Cancer Cell Networks Program is to promote investigation that will lead to a mechanistic understanding of aberrant cell regulatory networks supporting tumorigenesis. Approaches range from structural biology to animal models, and much in between. To promote cancer relevance and synergy across Simmons Cancer Center efforts, our scientific goals are broad and remain much the same as in the last submission: Goal 1) Define the mechanisms and pathways that integrate external and internal regulatory cues at the cell autonomous level. Goal 2) Establish how aberrant cell regulatory behavior contributes to cell transformation and tumorigenesis. Goal 3) Facilitate interactions with translational and clinical scientists to test the therapeutic benefit of modulating cell regulatory components. As of 2012, the Cancer Cell Networks Program is co-led by Melanie Cobb, PhD, and James Brugarolas, MD, PhD. The program has grown; it now has 46 members in 17 departments and centers. Five members are Howard Hughes Medical Institute investigators; five, including the program leader, have been elected to the National Academy of Sciences; and one is a Nobel laureate. The investigators in the CCN Program are currently supported by $33.1 million in peer-reviewed funding with $5.0 million from the NCI and $11 million from the Cancer Prevention and Research Institute of Texas (CPRIT). Through a combination of member recruiting and programmatic interactions, the CCN has had much success in engaging the discovery power of UTSW investigators for the development of new cancer focused research initiatives. Since 2009 the members of the CCN Program have authored a total of 382 publications, with 14% of them being intra-programmatic, 34% being inter-programmatic, and 23% inter-institutional with authors from other NCI-designated cancer centers.