Cellular Networks in Cancer Program

癌症计划中的蜂窝网络

• 批准号: 10693205
• 负责人: MELANIE H. COBB
• 金额: $ 2.7万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10693205
• 关键词: Abnormal Cell; Acceleration; Basic Science; Bioenergetics; Biological Markers; Cancer Center Support Grant; Catchment Area; Cell Death Signaling Process; Cells; Cellular biology; Clinic; Clinical; Clinical Oncology; Collaborations; Complement; Comprehensive Cancer Center; DNA Sequence Alteration; Data; Development; Disease; Disease Progression; Doctor of Philosophy; Environment; Evolution; Faculty; Fostering; Funding; Gene Expression Regulation; Genetic; Goals; Growth; Guidelines; Homeostasis; Human; Immunobiology; Infrastructure; Intervention; Intervention Studies; Journals; Knowledge; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Medical center; Mentors; Metabolism; Molecular; Neoplasm Metastasis; Non-Malignant; Patients; Peer Review; Physicians; Physiology; Population; Population Research; Positioning Attribute; Prevention strategy; Primary Neoplasm; Process; Productivity; Publications; Renal carcinoma; Research; Research Personnel; Resistance; Resource Sharing; Role; Science; Scientist; Signal Transduction; Solid; Specimen; Structure; Therapeutic Intervention; Tissues; Translating; Translations; Tumor Cell Biology; Vision; Work; cancer initiation; cancer prevention; cancer therapy; cell behavior; collaborative environment; design; diagnostic technologies; epigenetic regulation; fundamental research; insight; inter-institutional; live cell imaging; member; mortality; neoplastic cell; novel strategies; prevent; programs; success; translational potential; treatment strategy; tumor; tumor microenvironment; tumor progression; tumorigenesis

The Cellular Networks in Cancer (CNC) Program is a scientifically rich, collaborative, and productive research program co-led by Melanie Cobb, PhD, and Ralph DeBerardinis, MD, PhD. The vision of the CNC Program is to advance the fundamental knowledge of both intercellular and intracellular networks that contribute to cancer initiation, tumorigenesis, and metastasis, then to translate these findings into novel approaches to cancer prevention and therapy. CNC’s overarching scientific goal is to promote discoveries in how perturbation in these cellular networks contribute to altered tissue physiology and promote cancer. The CNC Program provides a highly interactive research environment that capitalizes on the UT Southwestern Medical Center’s (UTSW) longstanding tradition of basic science discoveries and fosters translation of these discoveries into the development of new biomarkers, diagnostic technologies, and therapeutic interventions in clinical oncology- especially malignancies relevant to the SCCC catchment area (e.g., cancer of the lung and kidney). The program’s structure is purposefully designed to stimulate interdisciplinary intra- and interprogrammatic collaborations with the objective of delivering transformative discoveries. To accomplish this, the Co-Leaders established four vibrant and synergistic subprograms that deliberately align with the strengths of program members and specifically relate to states of perturbed tissue homeostasis in cancer: (1) Signaling and Cell Biology, (2) Epigenetics and Gene Regulation, (3) Immunobiology, and (4) Metabolism. Each subprogram is directed by an investigator who is highly respected for his or her science, mentoring, and collaborative spirit. The subprogram structure and activities have directly contributed to exciting new collaborative projects such as the SPORE in Kidney Cancer. The CNC Program is composed of 59 basic, computational, and physician-scientists from 19 departments and centers at UT Southwestern Medical Center. Seven members of the CNC are Howard Hughes Medical Institute investigators. Annual direct peer-reviewed funding to the CNC Program was $19.3M in 2019. This represents an increase of $3.8M as compared with 2014 data, which were adjusted to conform to revised NCI guidelines. NCI funding has likewise increased from $3M in 2014 to $3.9M in 2019. Program members have authored 750 publications since 2014: 14% represent intraprogrammatic work, 34% are interprogrammatic collaborations, 32% are inter-institutional, and 37% are in journals with an impact factor ≥ 10. CNC Program members are heavily reliant upon all six CCSG Shared Resources—especially Live Cell Imaging and Tissue Management—in furtherance of their scientific goals. The CNC Program’s success is supported by SCCC’s strong infrastructure and grounded in the program’s solid interactions among CNC members and the subprograms, as well as with other SCCC Research Program members and external collaborators.

癌症细胞网络（CNC）计划是一项科学丰富，合作和富有成效的研究 该计划由Melanie Cobb博士和Ralph DeBerardinis博士共同领导。CNC计划的愿景是 推进细胞间和细胞内网络的基础知识，有助于癌症 启动，肿瘤发生和转移，然后将这些发现转化为治疗癌症的新方法 预防和治疗。CNC的首要科学目标是促进这些微扰的发现。 细胞网络有助于改变组织生理学并促进癌症。CNC程序提供了一个 高度互动的研究环境，利用UT西南医学中心（UTSW） 基础科学发现的长期传统，并促进将这些发现转化为 在临床肿瘤学中开发新的生物标志物、诊断技术和治疗干预- 尤其是与SCCC集水区相关的恶性肿瘤（例如，肺癌和肾癌）。的 该项目的结构是专门设计的，旨在激发跨学科的项目内和项目间 合作的目标是提供变革性的发现。为了实现这一目标，联合领导人 建立了四个充满活力和协同作用的子计划，故意与计划的优势保持一致 本发明涉及癌症中受干扰的组织稳态的状态：（1）信号传导和细胞内分泌 生物学，（2）表观遗传学和基因调控，（3）免疫生物学，（4）代谢。每个子程序 由一位因其科学、指导和合作精神而备受尊敬的研究者指导。的 子计划的结构和活动直接促进了令人兴奋的新的合作项目，如 肾癌中的孢子CNC程序由59名基础、计算和物理科学家组成 来自UT西南医学中心的19个部门和中心。CNC的七名成员是霍华德 休斯医学研究所的研究人员。CNC计划的年度直接同行评审资金为1930万美元 2019年这比2014年的数据增加了380万美元，该数据经过调整以符合 修订的NCI指南。NCI的资金也从2014年的300万美元增加到2019年的390万美元。程序 自2014年以来，成员撰写了750篇出版物：14%代表计划内工作，34%代表计划外工作， 在跨学科合作中，32%是跨机构合作，37%是在影响因子≥ 10的期刊上。 CNC计划成员严重依赖所有六个CCSG共享资源-特别是活细胞成像 和组织管理，以促进其科学目标。CNC计划的成功得到了以下因素的支持： SCCC强大的基础设施，以及CNC成员和 子计划，以及与其他SCCC研究计划成员和外部合作者。