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The role of prefrontal sulcal morphology and brain network architecture in cognitive development

前额沟形态和脑网络结构在认知发展中的作用

基本信息

批准号：
10260547
负责人：
Silvia A. BUNGE
金额：
$ 22.8万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-09 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10260547
关键词：
Adolescent Adult Affect Age Anatomy Architecture Atlases Attention deficit hyperactivity disorder Autopsy Behavior Behavioral Bipolar Disorder Birth Blood Vessels Brain Brain imaging Brain region Cerebral hemisphere Cerebrum Child Childhood Cognition Cognitive Collaborations Data Data Set Development Diagnostic Foundations Functional Magnetic Resonance Imaging Future Genetic Human Imaging Techniques Individual Individual Differences Knowledge Lateral Lead Length Link Location Manuals Measures Methodology Methods Modernization Morphology Nature Neuroanatomy Neurodevelopmental Disorder Participant Pattern Perception Prefrontal Cortex Procedures Process Reporting Research Role Schizophrenia Shapes Standardization Structure Surface Testing Time Uterus Validation Vision Visual Cortex age related association cortex base behavior measurement biomarker identification cognitive capacity cognitive development cognitive function cognitive neuroscience cognitive skill cognitive testing improved in utero innovation inter-individual variation longitudinal dataset multimodality myelination network architecture neural circuit neuroimaging neurotransmission novel predictive modeling prenatal theories tool

项目摘要

PROJECT SUMMARY A distinctive feature of the human brain is the many folds (sulci) in the cortex. Estimates are that 60-70% of the cortex is hidden in sulcal depths. Sulci appear at different time periods in the womb: those that appear early (primary) are hypothesized to be under tighter genetic control, and therefore more similar in location and shape across people, than those that develop later (tertiary). Although modern cognitive neuroscience has largely overlooked these later-developing sulci, for historical and methodological reasons, patterns of tertiary sulci are theorized to have functional significance (Sanides, 1964). Elaborating on this idea, we theorize that sulcal deepening during development pulls cortical regions closer together, which minimizes wiring length and increases the efficiency of local neural signals, which in turn could contribute to improved cognitive functioning. The central hypothesis of this R21 proposal is that the development of tertiary sulci in association cortices has consequences for the development of functional brain architecture and high-level cognition. We propose to test this hypothesis for the first time, focusing on the long overlooked tertiary sulci in lateral prefrontal cortex (latPFC), a brain region implicated in higher-level cognitive capacities such as reasoning. To explore the functional significance of these latPFC sulci, we propose to characterize the relationships between sulcal anatomy, reasoning ability, and functional brain architecture in individual participants. To this end, we will leverage an existing multimodal, longitudinal dataset of 148 participants ages 6-20 that includes anatomical and functional MRI and behavioral measures. In Aim 1a, all latPFC tertiary sulci in both hemispheres of the brain in each individual will be manually defined, as modern automated methods to identify sulci do not include tertiary sulci. Aim 1b is to develop an automated approach to identify all latPFC tertiary sulci that we will share freely with the field. Once the lengthy process of sulcal definition is complete, we will examine whether features of latPFC tertiary sulci develop with age (Aim 2a). We will then test whether individual differences in these features helps to explain and/or predict differences in reasoning ability, measured as a latent factor based on three standardized assessments (Aim 2b). Finally, to relate brain anatomy with brain function, we will test whether individual latPFC tertiary sulci serve as landmarks identifying functional regions during a reasoning task, and whether sulcal- functional relationships are stable or change over development (Aim 3). Theoretically, our proposal advances theories linking the development of neuroanatomical and functional features of latPFC to cognitive development and tests a classic hypothesis. Methodologically, it should yield automated tools to define latPFC tertiary sulci, which could also be applied to other cortical locations in the future. Translationally, as previous studies reported latPFC sulcal anomalies in ADHD, schizophrenia, and bipolar disorder, but did not consider tertiary sulci or examine developmental trajectories, the proposed research will serve as a foundation for future studies of the role of sulcal anatomy in neurodevelopmental disorders.

项目总结