CORE C: STATISTICS AND INFORMATICS

项目总结/摘要 UCSF TCORS中心的统计和信息学核心将为所有人提供全面和持续的支持。 中心的统计分析和数据管理活动。这一核心将继续促进UCSF TCORS对烟草监管科学采取有凝聚力的方法的传统，将有助于实现该中心的 结合健康影响、行为和影响分析的综合主题， 关于当前和新兴烟草产品的监管和公共宣传信息。这 核心将通过实现两个具体目标来实现这些目标：（1）通过以下方式提供定量支持： 为所有项目提供研究规划、数据管理支持以及生物统计咨询和分析;以及（2） 为协作和数据共享提供培训、支持和资源。这个核心将参与所有五个 该中心的项目，快速反应项目，发展试点项目，和学员在职业生涯 增强核心。我们将与每个项目团队合作，以确保研究设计得当， 进行样本量和功效分析，帮助制定措施，创建随机化计划， 并制定分析计划。这一核心将有助于年轻人的职业发展， 需要统计咨询或项目支持的调查人员。我们将利用我们的经验， 烟草研究和数据系统与项目小组合作，进行安全的数据采集， 数据质量，监测项目进度，完成分析准备数据集，并进行生物统计 项目分析。我们将协调和管理数据共享请求。该核心还将培训项目 团队成员使用安全的数据系统进行数据采集和管理，建立和使用安全的 网站，用于分发研究文件，去除数据集的标识，并向公众提供， 通过UCSF DataShare进行数据共享。

PROJECT SUMMARY/ABSTRACT The Statistics and Informatics Core of this UCSF TCORS Center will provide full and ongoing support for all statistical analysis and data management activities of the Center. This Core will continue to facilitate the UCSF TCORS' tradition of a cohesive approach to tobacco regulatory science and will help achieve the center's integrated theme of combining health effects, behavior, and impact analysis to provide actionable information for regulation of and public communications about current and emerging tobacco products. This Core will achieve these goals by accomplishing two Specific Aims: (1) Provide quantitative support through research planning, support for data management, and biostatistical advice and analysis to all projects; and (2) Provide training, support and resources for collaboration and data sharing. This Core will be engaged in all five of the Center projects, the Rapid Response Projects, Developmental Pilot Projects, and trainees in the Career Enhancement Core. We will collaborate with each project team to ensure the study is properly designed, conduct sample size and power analyses, help develop measures, create randomization schedules when applicable, and develop analysis plans. This Core will contribute to the career enhancement of young investigators needing statistical advice or support with their projects. We will leverage our experience in tobacco research and data systems to collaborate with the project teams on secure data acquisition, assuring data quality, monitoring project progress, finalizing analysis-ready data sets, and performing biostatistical analysis for projects. We will coordinate and manage requests for data sharing. This Core will also train project team members to use the secured data system for data acquisition and management, build and use a secured website for the distribution of study documents, and de-identify data sets and make them publicly available for data sharing via UCSF DataShare.