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Sleep and circadian effects on memory in healthy young and older adults

睡眠和昼夜节律对健康年轻人和老年人记忆力的影响

基本信息

批准号：
10265994
负责人：
Robin Yuan
金额：
$ 3.1万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-15 至 2021-01-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10265994
关键词：
Address Adult Affect Alzheimer&apos s Disease Area Behavior Therapy Biological Centers for Disease Control and Prevention (U.S.)Chronic Circadian Rhythms Cognition Cognitive deficits Complex Conflict (Psychology)Data Data Analyses Dementia Development Elderly Exhibits Face Fellowship Health Healthcare Human Impaired cognition Impairment Individual Individual Differences Inpatients Learning Light Measures Memory Mental disorders Modernization Names Nature Outcome Paired-Associate Learning Patients Performance Periodicity Play Population Prevalence Reporting Research Role Running Schizophrenia Sleep Sleep Architecture Sleep Deprivation Sleep Disorders Sleep Stages Sleep disturbances Societies Structure Task Performances Testing Therapeutic Intervention Time Training Variant Wakefulness age difference age related aged awake circadian classical conditioning design experience experimental study follow-up healthy aging individual variation memory consolidation nervous system disorder neurobehavioral neurobehavioral test non rapid eye movement novel patient population performance tests preservation procedural memory young adult

项目摘要

Project Summary/Abstract Sleep is widely believed to play a critical role in memory consolidation, but the exact nature of this role remains controversial. Sleep disturbances are commonly reported in patients with neurologic and psychiatric disorders such as Alzheimer’s disease[1, 2] or schizophrenia [3] as well as in normal healthy aging [4], raising the possibility that alterations in sleep may underlie some of the cognitive impairments reported in these populations. Moreover, recent CDC data estimates that over a third of U.S. adults experience chronic insufficient sleep [5], which may have immediate and long-term consequences on cognition. While there is abundant evidence that sleep is important for learning [6], other factors such as circadian timing, age, and individual differences may also have an effect on learning, both directly and indirectly via their effects on sleep. These areas must be addressed in order to further develop our understanding of the complex relationship between sleep and memory. We have previously found circadian- and wake-dependent influences on performance in healthy young and older adults, using several different neurobehavioral tests [7, 8]. However, it is unclear whether the duration of wakefulness and biological timing impact memory tasks in a similar way, particularly among older adults. Additionally, we have previously demonstrated that performance on a face-name association memory task was enhanced in young adults when an overnight sleep opportunity was included in the retention interval [9], but were unable to identify an association between performance on this task and sleep duration or any sleep stage. Here, we propose to investigate whether circadian timing or duration of time awake affects short-term word-pair or face-name memory and whether this differs between young and older adults, using existing data collected from two different memory tasks administered over the course of a highly controlled inpatient sleep and circadian rhythm study. In addition, we propose to follow up on our previous study by collecting new data to investigate whether sleep duration or structure enhance performance on a face-name memory task, using repeated testing across multiple nights in the same individuals. Understanding how sleep, duration of waking, and biological timing impact memory and how those impacts may differ with healthy aging is critical to understanding cognitive deficits in populations with disrupted sleep.

项目总结/文摘