Sleep and circadian effects on memory in healthy young and older adults

睡眠和昼夜节律对健康年轻人和老年人记忆力的影响

基本信息

批准号：
10265994
负责人：
Robin Yuan
金额：
$ 3.1万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-15 至 2021-01-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10265994
关键词：
Address Adult Affect Alzheimer&apos s Disease Area Behavior Therapy Biological Centers for Disease Control and Prevention (U.S.)Chronic Circadian Rhythms Cognition Cognitive deficits Complex Conflict (Psychology)Data Data Analyses Dementia Development Elderly Exhibits Face Fellowship Health Healthcare Human Impaired cognition Impairment Individual Individual Differences Inpatients Learning Light Measures Memory Mental disorders Modernization Names Nature Outcome Paired-Associate Learning Patients Performance Periodicity Play Population Prevalence Reporting Research Role Running Schizophrenia Sleep Sleep Architecture Sleep Deprivation Sleep Disorders Sleep Stages Sleep disturbances Societies Structure Task Performances Testing Therapeutic Intervention Time Training Variant Wakefulness age difference age related aged awake circadian classical conditioning design experience experimental study follow-up healthy aging individual variation memory consolidation nervous system disorder neurobehavioral neurobehavioral test non rapid eye movement novel patient population performance tests preservation procedural memory young adult

项目摘要

Project Summary/Abstract Sleep is widely believed to play a critical role in memory consolidation, but the exact nature of this role remains controversial. Sleep disturbances are commonly reported in patients with neurologic and psychiatric disorders such as Alzheimer’s disease[1, 2] or schizophrenia [3] as well as in normal healthy aging [4], raising the possibility that alterations in sleep may underlie some of the cognitive impairments reported in these populations. Moreover, recent CDC data estimates that over a third of U.S. adults experience chronic insufficient sleep [5], which may have immediate and long-term consequences on cognition. While there is abundant evidence that sleep is important for learning [6], other factors such as circadian timing, age, and individual differences may also have an effect on learning, both directly and indirectly via their effects on sleep. These areas must be addressed in order to further develop our understanding of the complex relationship between sleep and memory. We have previously found circadian- and wake-dependent influences on performance in healthy young and older adults, using several different neurobehavioral tests [7, 8]. However, it is unclear whether the duration of wakefulness and biological timing impact memory tasks in a similar way, particularly among older adults. Additionally, we have previously demonstrated that performance on a face-name association memory task was enhanced in young adults when an overnight sleep opportunity was included in the retention interval [9], but were unable to identify an association between performance on this task and sleep duration or any sleep stage. Here, we propose to investigate whether circadian timing or duration of time awake affects short-term word-pair or face-name memory and whether this differs between young and older adults, using existing data collected from two different memory tasks administered over the course of a highly controlled inpatient sleep and circadian rhythm study. In addition, we propose to follow up on our previous study by collecting new data to investigate whether sleep duration or structure enhance performance on a face-name memory task, using repeated testing across multiple nights in the same individuals. Understanding how sleep, duration of waking, and biological timing impact memory and how those impacts may differ with healthy aging is critical to understanding cognitive deficits in populations with disrupted sleep.

项目摘要/摘要人们普遍认为睡眠在记忆巩固中起着至关重要的作用，但是这种角色的确切性质仍然有争议。神经系统和精神病患者通常报告睡眠障碍阿尔茨海默氏病[1,2]或精神分裂症[3]以及正常健康衰老[4]等疾病[3] 睡眠改变可能是其中一些认知障碍的可能性人群。此外，最近的CDC数据估计，超过三分之一的美国成年人经历了慢性不足睡眠[5]，可能会立即对认知产生直接和长期的影响。虽然有很多睡眠对于学习很重要的证据[6]，其他因素，例如昼夜节律，年龄和个人差异也可能会通过对睡眠的影响直接或间接地学习产生影响。这些必须解决领域，以进一步发展我们对之间复杂关系的理解睡眠和记忆。我们以前曾发现昼夜节律依赖对健康年轻人表现的影响和老年人，使用几种不同的神经行为测试[7，8]。但是，尚不清楚持续时间是否清醒和生物时机以类似的方式影响记忆任务，尤其是在老年人中。此外，我们以前已经证明了面部名称关联记忆任务的性能是当保留间隔包括过夜睡眠机会时，年轻人的增强[9] 无法确定在此任务和睡眠持续时间或任何睡眠阶段的性能之间的关联。在这里，我们建议调查昼夜节律的时间或戒断时间是否会影响短期单词对或使用现有数据收集的现有数据从高度控制的住院睡眠和昼夜节律的过程中管理的两个不同的内存任务节奏研究。此外，我们建议通过收集新数据来调查以前的研究。是否使用重复测试，无论是睡眠持续时间还是结构增强面部名称内存任务的性能在同一个人中度过了多个晚上。了解睡眠，醒来的持续时间和生物学时间影响记忆以及这些影响如何随着健康衰老而有所不同，对于理解认知至关重要睡眠干扰人群的缺陷。