Research Support Core: Synthesis Core

概要：合成核心 爱荷华州大学的超级基金研究项目（ISRP）支持对 多氯联苯（PCBs）是一种重要的空气污染物， 超级基金化学品ISRP生物医学和环境研究项目需要进行各种研究 从工业和合成多氯联苯混合物到纯多氯联苯同系物及其代谢物 用于研究这些多氯联苯同系物的挥发、迁移、接触、毒性和补救措施。一个主要 这些研究的障碍是大量的209多氯联苯同系物加上大量的837可能 单羟基化（OH-PCB）、硫酸化（PCB硫酸盐）、葡萄糖醛酸化（PCB葡萄糖醛酸）和其他PCB 代谢物。这些多氯联苯衍生物中有许多无法从商业来源获得或从未获得过 合成之前。从商业来源获得多氯联苯混合物或单个多氯联苯同系物也可 价格昂贵，特别是如果动物研究需要大量。此外，关于他们的信息 合成通常不能从商业来源获得。为了促进创新的研究建议， 根据ISRP的研究项目，迫切需要生产足够数量的多氯联苯及其 可用于研究挥发、运输、暴露、毒性和补救的代谢物 PCB。为了满足这一关键需求，综合核心的主要目标是提供各种各样的 以及时且具有成本效益的方式向ISRP提供经过充分认证的高纯度PCB衍生物，并且随着时间的推移 和资源允许的情况下，其他研究人员。为实现这一目标，综合核心将综合和 保持广泛的PCB衍生物，并采用严格的准则来验证这些关键 化学品与此同时，合成核心将继续开发新的合成策略， 根据ISRP研究人员的需要，合成多氯联苯同系物和多氯联苯代谢物。的具体目标 ISRP合成核心是：1）保持和制备多氯联苯混合物和纯多氯联苯同系物; 2）制备 羟基化PCB衍生物; 3）合成PCB硫酸盐代谢物;和4）制备杂项 化合物，如：PCB氢醌、PCB儿茶酚、PCB醌、PCB谷胱甘肽和N- 乙酰半胱氨酸缀合物。及时提供多氯联苯混合物、单独的羟基多氯联苯、多氯联苯硫酸盐和 其他多氯联苯代谢物将大大提高，如果相应的多氯联苯代谢物无法从 商业来源，使创新的研究提出的ISRP研究项目。此外，使用 在几个ISRP研究项目中经过良好认证的测试化合物将大大提高严格性， ISRP研究的可重复性。

SUMMARY: Synthesis Core The Superfund Research Program at The University of Iowa (ISRP) supports investigations of the consequences of sources and exposures to all airborne polychlorinated biphenyls (PCBs), an important class of Superfund chemicals. ISRP biomedical and environmental research projects require a variety of study compounds ranging from technical and synthetic PCB mixtures to pure PCB congeners and their metabolites for studies of the volatilization, transport, exposure, toxicity, and remediation of these PCB congeners. A major obstacle for these studies is the large number of 209 PCB congeners plus the large number of 837 possible mono-hydroxylated (OH-PCBs), sulfated (PCB sulfates), glucuronidated (PCB glucuronides) and other PCB metabolites. Many of these PCB derivatives are not available from commercial sources or have never been synthesized before. Obtaining PCB mixtures or individual PCB congeners from commercial sources can also be expensive, especially if large quantities are needed for animal studies. Moreover, information about their synthesis is typically not available from commercial sources. To facilitate the innovative studies proposed by individual ISRP research projects, there is a critical need to make sufficient quantities of PCBs and their metabolites available for studies investigating the volatilization, transport, exposure, toxicity, and remediation of PCBs. To address this critical need, the major objective of the Synthesis Core is to provide a large variety of well-authenticated and highly-pure PCB derivatives in a timely and cost-efficient manner to ISRP and, as time and resources allow, other researchers. To attain this objective, the Synthesis Core will synthesize and maintain a broad range of PCB derivatives and employ rigorous guidelines for the authentication of these key chemicals. At the same time, the Synthesis Core will continue to develop novel synthetic strategies for the synthesis of PCB congeners and PCB metabolites as needed by ISRP researchers. The Specific Aims of the ISRP Synthesis Core are to: 1) maintain and prepare PCB mixtures and pure PCB congeners; 2) prepare hydroxylated PCB derivatives; 3) synthesize PCB sulfate metabolites; and 4) prepare miscellaneous compounds, such as: PCB hydroquinones, PCB catechols, PCB quinones, and PCB glutathione and N- acetylcysteine conjugates. The timely availability of PCB mixtures, individual OH-PCBs, PCB sulfates and other PCB metabolites will greatly enhance and, if the respective PCB metabolites are unavailable from commercial sources, enable the innovative studies proposed by ISRP Research Projects. Moreover, the use of well-authenticated test compounds across several ISRP research projects will greatly enhance the rigor and reproducibility of ISRP research.