Religion and support for genomic healthcare: An exploratory study of the US public and faith leaders.

项目摘要 宗教是关注基因组学和基因组医疗保健（GGH）的主要驱动力。这对研究至关重要 关于基因组学的伦理、法律的和社会影响（ELSI），以了解宗教在塑造 公众对GGH的态度。90%的美国公众相信某种更高的权力， 每天祈祷。美国公众参加宗教服务的比率是美国科学家的3倍， 有可能误解宗教在对GGH的态度中所起的作用。此外，黑人、西班牙裔和农村 美国民众参加宗教仪式的频率高于一般美国民众。关注GGH 活动可能导致GGH的参与程度较低，这反过来又可能导致健康差距。 这个项目旨在了解为什么更高层次的宗教实践与更大的关注有关 GGH的活动。 此外，该项目将采访宗教领袖，以确定公共卫生基因组学如何参与 以尊重和建设性的方式建立信仰社区。虽然一些关于医疗保健的担忧 技术可能会随着新的信息而消失，其他的则源于世界观，深刻的道德承诺， 或者对医疗系统的不信任让宗教团体参与进来对于确定哪些关切至关重要 可以通过信息来解决，这些信息需要替代反应，以及哪些替代反应可能 看起来像。很少有基因组公共卫生与宗教接触的模式，特别是 13，14该项目将实现两个具体目标： 1.定量研究宗教的哪些方面解释了它对GGH活动支持的影响。 我们将在美国调查4800名成年人，以研究宗教变量与GGH支持的关联 产前基因检测、基因编辑和mRNA疫苗等活动。我们将生成丰富的描述性 数据和探索如何以及何时不同的宗教变量预测支持，或反对，GGH活动。 2.探索基因组公共卫生如何以一种 尊重和建设性。我们将通过Zoom对180位信仰领袖进行深入采访，其中30位来自 六个团体：福音派，主流新教，历史上的黑人，天主教基督教，犹太教， 和伊斯兰教。这些团体代表了美国最大的宗教团体，占美国90%的宗教团体。 宗教信仰访谈将探讨几个不同的问题：他们对GGH活动的看法是什么？是 在他们的社区内容忍这些问题上的不同意见？对GGH的关注程度 原则性活动，进一步的信息在多大程度上可能有所帮助？基因组公共卫生 以尊重和建设性的方式与宗教团体接触？

Project Summary Religion is a primary driver of concerns with genomics and genomic healthcare (GGH). It is vital for research on the ethical, legal, and social implications (ELSI) of genomics to understand the role of religion in shaping public attitudes toward GGH. Ninety percent of the US public believes in some kind of higher power and 55% pray daily. The US public attends religious services at a rate 3 times higher than scientists in the US, who are at risk of misunderstanding the role religion plays in attitudes toward GGH. Further, Black, Hispanic, and rural populations attend religious services more frequently than the general US public. Concerns with GGH activities may lead to lower levels of engagement of GGH, which may in turn contribute to health disparities. This project aims to understand why higher levels of religious practice are associated with greater concerns with GGH activities. Additionally, this project will interview faith leaders to identify how public health genomics might engage faith communities in ways that are respectful and constructive. While some concerns with healthcare technologies may disappear with new information, others stem from worldviews, deep moral commitments, or mistrust of the healthcare system. Engaging religious communities is essential to identify which concerns can be addressed with information, which call for alternative responses, and what alternative responses might look like. Very few models exist for genomic public health engagement with religion, particularly models that directly address value-laden concerns.13,14 This project will achieve two specific aims: 1. Quantitatively examine which aspects of religion explain its influence on support for GGH activities. We will survey 4800 adults in the US to examine the association of religious variables with support for GGH activities such as prenatal genetic testing, gene editing, and mRNA vaccines. We will generate rich descriptive data and explore how and when diverse religious variables predict support for, or opposition to, GGH activities. 2. Explore how genomic public health can engage with religious communities in a way that is respectful and constructive. We will conduct in-depth interviews via Zoom with 180 faith leaders—30 from each of six groups: Evangelical, Mainline Protestant, Historically Black, and Catholic Christianity, Judaism, and Islam. These groups represent the largest religious groups in the US, comprising 90% of those with a religious affiliation. Interviews will explore several different issues: What are their views on GGH activities? Is diversity of opinion on these matters tolerated within their community? To what extent are concerns with GGH activities principled and to what extent might further information be helpful? How might genomic public health engage religious communities in a way that is both respectful and constructive?