Religion and support for genomic healthcare: An exploratory study of the US public and faith leaders.

项目摘要 宗教是对基因组学和基因组医疗保健(GGH)的担忧的主要驱动因素。这对研究是至关重要的 关于基因组学的伦理、法律和社会影响(ELSI)，以了解宗教在塑造中的作用 公众对GGH的态度。90%的美国公众相信某种更高的权力，55%的人相信 每天祈祷。美国公众参加宗教仪式的比例是美国科学家的3倍，后者是 可能会误解宗教在对待GGH的态度中所起的作用。此外，黑人、西班牙裔和农村人 人们参加宗教仪式的频率比普通美国公众更高。对GGH的担忧 这些活动可能导致GGH参与度较低，进而可能导致健康差距。 这个项目旨在了解为什么更高水平的宗教实践与更大的担忧有关。 与GGH活动有关。 此外，该项目将采访宗教领袖，以确定公共卫生基因组学可能如何参与 以尊重和建设性的方式建立信仰社区。虽然对医疗保健的一些担忧 技术可能会随着新的信息而消失，其他技术可能源于世界观、深刻的道德承诺、 或者对医疗体系的不信任。宗教团体的参与对于确定哪些关切是至关重要的 可以用信息来解决，哪些需要替代应对措施，以及哪些替代应对措施可能 看起来像。很少存在与宗教有关的基因组公共卫生参与的模型，特别是 直接解决有价值的问题。13、14本项目将实现两个具体目标： 1.定量研究宗教的哪些方面可以解释其对支持GGH活动的影响。 我们将对4800名美国成年人进行调查，以检验宗教变量与GGH支持率之间的联系 例如产前基因测试、基因编辑和信使核糖核酸疫苗。我们将生成丰富的描述性 数据和探索不同的宗教变量如何以及何时预测支持或反对GGH活动。 2.探索基因组公共卫生如何以一种 尊重他人，富有建设性。我们将通过Zoom对180名宗教领袖进行深入采访-其中30人来自 六个团体中的每一个：福音派、主流新教徒、历史上的黑人、天主教基督教、犹太教、 和伊斯兰教。这些团体代表了美国最大的宗教团体，占拥有 宗教信仰。访谈将探讨几个不同的问题：他们对GGH活动的看法是什么？是 在这些问题上的不同意见在他们的社区内是容忍的吗？对GGH的担忧达到了什么程度 有原则的活动，以及进一步的信息在多大程度上可能是有帮助的？基因组公共卫生如何 以一种既尊重又有建设性的方式接触宗教团体？

Project Summary Religion is a primary driver of concerns with genomics and genomic healthcare (GGH). It is vital for research on the ethical, legal, and social implications (ELSI) of genomics to understand the role of religion in shaping public attitudes toward GGH. Ninety percent of the US public believes in some kind of higher power and 55% pray daily. The US public attends religious services at a rate 3 times higher than scientists in the US, who are at risk of misunderstanding the role religion plays in attitudes toward GGH. Further, Black, Hispanic, and rural populations attend religious services more frequently than the general US public. Concerns with GGH activities may lead to lower levels of engagement of GGH, which may in turn contribute to health disparities. This project aims to understand why higher levels of religious practice are associated with greater concerns with GGH activities. Additionally, this project will interview faith leaders to identify how public health genomics might engage faith communities in ways that are respectful and constructive. While some concerns with healthcare technologies may disappear with new information, others stem from worldviews, deep moral commitments, or mistrust of the healthcare system. Engaging religious communities is essential to identify which concerns can be addressed with information, which call for alternative responses, and what alternative responses might look like. Very few models exist for genomic public health engagement with religion, particularly models that directly address value-laden concerns.13,14 This project will achieve two specific aims: 1. Quantitatively examine which aspects of religion explain its influence on support for GGH activities. We will survey 4800 adults in the US to examine the association of religious variables with support for GGH activities such as prenatal genetic testing, gene editing, and mRNA vaccines. We will generate rich descriptive data and explore how and when diverse religious variables predict support for, or opposition to, GGH activities. 2. Explore how genomic public health can engage with religious communities in a way that is respectful and constructive. We will conduct in-depth interviews via Zoom with 180 faith leaders—30 from each of six groups: Evangelical, Mainline Protestant, Historically Black, and Catholic Christianity, Judaism, and Islam. These groups represent the largest religious groups in the US, comprising 90% of those with a religious affiliation. Interviews will explore several different issues: What are their views on GGH activities? Is diversity of opinion on these matters tolerated within their community? To what extent are concerns with GGH activities principled and to what extent might further information be helpful? How might genomic public health engage religious communities in a way that is both respectful and constructive?