Collaborative Research and Action: Empowering an Exposed Community

协作研究和行动：为暴露的社区赋权

• 批准号: 10578519
• 负责人: MICHELE MARCUS
• 金额: $ 30.35万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10578519
• 关键词: Address; Advisory Committees; Affect; Age at Menarche; Agriculture; Animals; Arthralgia; Arthritis; Attention; Autoimmune; Awareness; Body Burden; Breast Feeding; Chemicals; Child; Clinical Trials; Communities; DNA; DNA Methylation; Data; Disasters; Double-Blind Method; Double-blind trial; Educational Materials; Endocrine Disruptors; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Estrogens; Event; Exposure to; Family; Family Study; Family health status; Fathers; Female; Flame Retardants; Food Chain; Frustration; Funding; Future Generations; Gene Expression; Generations; Genitourinary system; Goals; Growth and Development function; Health; Health Fairs; Health Personnel; Heritability; Human; Human body; Individual; Inherited; Leadership; Liver; Livestock; Malignant Neoplasms; Maternal Exposure; Menarche; Methods; Michigan; Migraine; Mothers; Nerve Degeneration; Neurodegenerative Disorders; Neurologic; Nutritional; Outcome; Pain Disorder; Pancreas; Parents; Participant; Patient Recruitments; Pattern; Persons; Pilot Projects; Poison; Policy Maker; Polybrominated Biphenyls; Public Health; Questionnaires; Randomized; Recording of previous events; Registries; Replacement Arthroplasty; Reproduction; Reproductive system; Research; Research Personnel; Risk; Rivers; Sampling; Scientist; Serum; Ships; Somatic Cell; Spontaneous abortion; Superfund; Time; Universities; Uterus; Woman; Work; adverse outcome; cohort; college; dietary; dietary supplements; empowered; endocrine disruptor exposure; epigenome; experience; immune function; interest; lipophilicity; male; meetings; member; men; methylation pattern; offspring; parent grant; persistent organic pollutants; programs; recruit; reproductive outcome; social media; sperm cell; tool

Project Summary/Abstract: The Michigan PBB Registry was established in order to study the health of thousands of people exposed to brominated flame retardants as a result of the largest agricultural disaster in US history. Previous research by this team has shown significant health effects associated with exposure to polybrominated biphenyls (PBB) including earlier menarche, increased risk of miscarriages and lower estrogen levels among women, and more urogenital problems among men. Over the past few years, Emory researchers have conducted over two dozen community meetings throughout Michigan, collaborated with community partners, shared research findings with the community, responded to community needs, and sought community input for future research plans. This proposed study, collaboratively developed by scientists, community partners, and public health officials, addresses several major concerns expressed by the PBB community. Specifically, affected individuals have expressed interest in a possible treatment to remove PBBs from their bodies, concern about heritable effects from PBB on their children and grandchildren, continuing health concerns beyond those related to reproduction, and frustration that local health-care providers seem unaware of the statewide PBB exposure and/or its possible health effects. To address these concerns, the proposed study has four specific aims. The first is to evaluate the utility of a nutritional aid as a potential means of accelerating the elimination of PBB by conducting a randomized double-blind clinical trial. The second aim will explore the heritability of changes in the epigenome associated with PBB exposure by studying families across three generations. The epigenome of parents, their children, and their grandchildren will be examined to determine if epigenetic patterns associated with direct exposure to PBB of parents are apparent in the children and grandchildren. Aim three will address community concerns regarding additional health effects beyond reproductive outcomes. Participants will complete health questionnaires and provide serum samples for analysis to determine if PBB exposure is associated with neurodegenerative diseases, joint pain/disorder, cancer, immune function and liver/pancreatic problems. If any of the self-identified adverse outcomes are associated with PBB exposure, additional funding will be sought to further explore these associations. Finally, the public health action plan will seek to raise environmental health awareness in Michigan. Educational programs will be developed for healthcare providers, policy-makers, and citizens to increase local capacity to address exposure concerns.

项目总结/文摘: