Collaborative Research and Action: Empowering an Exposed Community

协作研究和行动：为暴露的社区赋权

• 批准号: 9920012
• 负责人: MICHELE MARCUS
• 金额: $ 55.5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9920012
• 关键词: Address; Advisory Committees; Affect; Age at Menarche; Agriculture; Animals; Arthralgia; Arthritis; Attention; Autoimmune Process; Awareness; Body Burden; Breast Feeding; Chemicals; Child; Communities; DNA; DNA Methylation; Data; Disasters; Double-blind trial; Educational Materials; Employee; Endocrine Disruptors; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Estrogens; Event; Exposure to; Family; Family health status; Fat Substitutes; Fathers; Female; Flame Retardants; Food Chain; Frustration; Funding; Future Generations; Gene Expression; Generations; Genitourinary system; Goals; Health; Health Fairs; Health Personnel; Heritability; Human; Human body; Individual; Inherited; Leadership; Left; Liver; Livestock; Malignant Neoplasms; Maternal Exposure; Medical; Menarche; Methods; Michigan; Migraine; Mothers; Municipalities; Neighborhoods; Nerve Degeneration; Neurodegenerative Disorders; Neurologic; Outcome; Pain Disorder; Pancreas; Parents; Participant; Patient Recruitments; Pattern; Pilot Projects; Poison; Policy Maker; Polybrominated Biphenyls; Public Health; Questionnaires; Randomized; Recording of previous events; Registries; Replacement Arthroplasty; Reproduction; Reproductive system; Research; Research Personnel; Risk; Rivers; Sampling; Scientist; Serum; Ships; Somatic Cell; Spontaneous abortion; Superfund; Time; Universities; Uterus; Water Supply; Woman; Work; adverse outcome; cohort; college; dietary supplements; empowered; endocrine disruptor exposure; epigenome; experience; immune function; interest; lipophilicity; male; meetings; member; men; methylation pattern; offspring; persistent organic pollutants; programs; public health relevance; recruit; reproductive; response; social media; sperm cell; superfund site; tool

 DESCRIPTION (provided by applicant): The Michigan PBB Registry was established in order to study the health of thousands of people exposed to brominated flame retardants as a result of the largest agricultural disaster in US history. Previous research by this team has shown significant health effects associated with exposure to polybrominated biphenyls (PBB) including earlier menarche, increased risk of miscarriages and lower estrogen levels among women, and more urogenital problems among men. Over the past few years, Emory researchers have conducted over a dozen community meetings throughout Michigan, collaborated with community partners, shared research findings with the community, responded to community needs, and sought community input for future research plans. This proposed study, collaboratively developed by scientists, community partners, and public health officials, addresses several major concerns expressed by the PBB community. Specifically, affected individuals have expressed interest in a possible treatment to remove PBBs from their bodies, concern about heritable effects from PBB on their children and grandchildren, continuing health concerns beyond those related to reproduction, and frustration that local health-care providers seem unaware of the statewide PBB exposure and/or its possible health effects. To address these concerns, the proposed study has four specific aims. The first is to evaluate the utility of nutritional supplement, a non-absorbable artificial fat, as a potential means of accelerating the elimination of PBB by conducting a randomized double-blind trial. The second aim will explore the heritability of changes in the epigenome associated with PBB exposure by studying 25 families across three generations. The epigenome of parents, their children, and their grandchildren will be examined to determine if epigenetic patterns associated with direct exposure to PBB of parents are apparent in the children and grandchildren. Aim three will address community concerns regarding additional health effects beyond reproductive outcomes. Participants, including 575 new enrollees, will complete health questionnaires and provide serum samples for analysis to determine if PBB exposure is associated with neurodegenerative diseases, joint pain/disorder, cancer, immune function and liver/pancreatic problems. If any of the self-identified adverse outcomes are associated with PBB exposure, additional funding will be sought to further explore these associations. Finally, the public health action plan will seek t raise environmental health awareness in Michigan. Educational programs will be developed for healthcare providers, policy-makers, and citizens to increase local capacity to address exposure concerns.

 描述（由申请人提供）：密歇根州 PBB 登记处的成立是为了研究美国历史上最大的农业灾难造成的数千名接触溴化阻燃剂的人的健康状况。该团队之前的研究表明，接触多溴联苯 (PBB) 会对健康产生重大影响，包括月经初潮提前、流产风险增加、女性雌激素水平降低以及男性泌尿生殖系统问题增多。在过去的几年里，埃默里大学的研究人员在密歇根州各地召开了十几次社区会议，与社区合作伙伴合作，与社区分享研究成果，回应社区需求，并为未来的研究计划寻求社区的意见。这项拟议的研究由科学家、社区合作伙伴和公共卫生官员共同开发，解决了 PBB 社区表达的几个主要问题。具体来说，受影响的个人表示对可能的治疗方法感兴趣，以清除体内的多溴联苯，担心多溴联苯对其子孙的遗传影响，对生殖相关健康问题的持续关注，以及对当地医疗保健提供者似乎不了解全州多溴联苯暴露和/或其可能的健康影响感到沮丧。为了解决这些问题，拟议的研究有四个具体目标。第一个是通过进行随机双盲试验来评估营养补充剂（一种不可吸收的人造脂肪）作为加速消除多溴联苯的潜在手段的效用。第二个目标是通过研究 25 个家庭的三代人，探讨与多溴联苯暴露相关的表观基因组变化的遗传性。将检查父母、子女和孙子女的表观基因组，以确定与父母直接接触多溴联苯相关的表观遗传模式在子女和孙子女中是否明显。目标三将解决社区对生殖结果之外的其他健康影响的担忧。参与者（包括 575 名新参与者）将完成健康调查问卷并提供血清样本进行分析，以确定多溴联苯暴露是否与神经退行性疾病、关节疼痛/疾病、癌症、免疫功能和肝脏/胰腺问题相关。如果任何自我认定的不良后果与多溴联苯暴露有关，将寻求额外资金来进一步探讨这些关联。最后，公共卫生行动计划将寻求提高密歇根州的环境健康意识。将为医疗保健提供者、政策制定者和公民制定教育计划，以提高当地解决暴露问题的能力。