Collaborative Research and Action: Empowering an Exposed Community

协作研究和行动：为暴露的社区赋权

• 批准号: 9920012
• 负责人: MICHELE MARCUS
• 金额: $ 55.5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9920012
• 关键词: Address; Advisory Committees; Affect; Age at Menarche; Agriculture; Animals; Arthralgia; Arthritis; Attention; Autoimmune Process; Awareness; Body Burden; Breast Feeding; Chemicals; Child; Communities; DNA; DNA Methylation; Data; Disasters; Double-blind trial; Educational Materials; Employee; Endocrine Disruptors; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Estrogens; Event; Exposure to; Family; Family health status; Fat Substitutes; Fathers; Female; Flame Retardants; Food Chain; Frustration; Funding; Future Generations; Gene Expression; Generations; Genitourinary system; Goals; Health; Health Fairs; Health Personnel; Heritability; Human; Human body; Individual; Inherited; Leadership; Left; Liver; Livestock; Malignant Neoplasms; Maternal Exposure; Medical; Menarche; Methods; Michigan; Migraine; Mothers; Municipalities; Neighborhoods; Nerve Degeneration; Neurodegenerative Disorders; Neurologic; Outcome; Pain Disorder; Pancreas; Parents; Participant; Patient Recruitments; Pattern; Pilot Projects; Poison; Policy Maker; Polybrominated Biphenyls; Public Health; Questionnaires; Randomized; Recording of previous events; Registries; Replacement Arthroplasty; Reproduction; Reproductive system; Research; Research Personnel; Risk; Rivers; Sampling; Scientist; Serum; Ships; Somatic Cell; Spontaneous abortion; Superfund; Time; Universities; Uterus; Water Supply; Woman; Work; adverse outcome; cohort; college; dietary supplements; empowered; endocrine disruptor exposure; epigenome; experience; immune function; interest; lipophilicity; male; meetings; member; men; methylation pattern; offspring; persistent organic pollutants; programs; public health relevance; recruit; reproductive; response; social media; sperm cell; superfund site; tool

 DESCRIPTION (provided by applicant): The Michigan PBB Registry was established in order to study the health of thousands of people exposed to brominated flame retardants as a result of the largest agricultural disaster in US history. Previous research by this team has shown significant health effects associated with exposure to polybrominated biphenyls (PBB) including earlier menarche, increased risk of miscarriages and lower estrogen levels among women, and more urogenital problems among men. Over the past few years, Emory researchers have conducted over a dozen community meetings throughout Michigan, collaborated with community partners, shared research findings with the community, responded to community needs, and sought community input for future research plans. This proposed study, collaboratively developed by scientists, community partners, and public health officials, addresses several major concerns expressed by the PBB community. Specifically, affected individuals have expressed interest in a possible treatment to remove PBBs from their bodies, concern about heritable effects from PBB on their children and grandchildren, continuing health concerns beyond those related to reproduction, and frustration that local health-care providers seem unaware of the statewide PBB exposure and/or its possible health effects. To address these concerns, the proposed study has four specific aims. The first is to evaluate the utility of nutritional supplement, a non-absorbable artificial fat, as a potential means of accelerating the elimination of PBB by conducting a randomized double-blind trial. The second aim will explore the heritability of changes in the epigenome associated with PBB exposure by studying 25 families across three generations. The epigenome of parents, their children, and their grandchildren will be examined to determine if epigenetic patterns associated with direct exposure to PBB of parents are apparent in the children and grandchildren. Aim three will address community concerns regarding additional health effects beyond reproductive outcomes. Participants, including 575 new enrollees, will complete health questionnaires and provide serum samples for analysis to determine if PBB exposure is associated with neurodegenerative diseases, joint pain/disorder, cancer, immune function and liver/pancreatic problems. If any of the self-identified adverse outcomes are associated with PBB exposure, additional funding will be sought to further explore these associations. Finally, the public health action plan will seek t raise environmental health awareness in Michigan. Educational programs will be developed for healthcare providers, policy-makers, and citizens to increase local capacity to address exposure concerns.

 描述（由适用提供）：建立了密歇根州PBB注册中心，以研究由于美国历史上最大的农业灾难而导致的成千上万人暴露于溴化火焰阻燃剂的人的健康。该团队的先前研究表明，与溴溴二苯基（PBB）暴露有关的重大健康影响，包括早期的初潮，流产的风险增加和女性中雌激素水平降低以及男性中泌尿生殖器的更多问题。在过去的几年中，埃默里（Emory）研究人员在密歇根州进行了十几次社区会议，与社区合作伙伴合作，与社区共享研究结果，满足社区需求，并为未来的研究计划感知社区的投入。这项由科学家，社区合作伙伴和公共卫生官员合作开发的拟议研究解决了PBB社区所表达的几个主要问题。具体而言，受影响的个体对可能的治疗方法表示兴趣，以从其身体中删除PBB，对PBB对孩子和孙子的遗传影响的担忧，持续的健康问题超出了与生殖有关的问题，以及对当地医疗保健提供者的沮丧，认为当地的医疗保健提供者似乎对全州PBB的PBB暴露以及/或其可能的健康影响没有意识。为了解决这些问题，拟议的研究具有四个具体目标。首先是评估营养补充剂的实用性，一种不可吸收的人造脂肪，是通过进行随机的双盲试验来加速消除PBB的潜在手段。第二个目标将通过研究三代人研究25个家庭，探索与PBB暴露有关的表观基因组变化的遗传力。将检查父母，孩子和他们的孙子的表观基因组，以确定与父母直接接触PBB有关的表观遗传学模式是否在孩子和孙子中显然是显而易见的。 AIM三将解决社区对除生殖结果以外其他健康影响的担忧。包括575名新入学的参与者将填写健康问卷，并提供血清样本进行分析，以确定PBB暴露是否与神经退行性疾病，关节疼痛/疾病，癌症，癌症，免疫功能和肝脏/胰腺问题有关。如果任何自我识别的不良后果与PBB暴露有关，则将有额外的资金来进一步探索这些关联。最后，公共卫生行动计划将寻求提高密歇根州的环境健康意识。将为医疗保健提供者，政策制定者和公民制定教育计划，以提高当地解决暴露问题的能力。