Polysubstance Drug Use in the General Population: Present Day Behaviors, Critical Windows, and Predictors of Psychoactive Drug Use

普通人群中的多物质药物使用：当今行为、关键窗口和精神活性药物使用的预测因素

• 批准号: 10572647
• 负责人: Karilynn Rockhill
• 金额: $ 3.16万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10572647
• 关键词: Address; Adult; Age; Behavior; Behavioral; Benzodiazepines; Caring; Cessation of life; Classification; Communities; Complex; Data Sources; Death Rate; Diagnosis; Dimensions; Drug abuse; Drug usage; Drug user; Epidemic; Family; Future; General Population; Glean; Goals; Health; Health Services Accessibility; Healthcare; Individual; Insurance Coverage; Intervention; Law Enforcement; Life; Life Experience; Longevity; Measures; Medical; Mental Health; Nature; Opioid; Overdose; Pattern; Peer Pressure; Persons; Pharmaceutical Preparations; Population; Predictive Factor; Predictive Value; Prevalence; Prevention; Psyche structure; Psychotropic Drugs; Public Health; Recording of previous events; Recreation; Recreational Drugs; Research; Respondent; Risk; Risk Factors; Societal Factors; Substance Abuse Detection; Substance Use Disorder; Surveys; Testing; Time; United States; Work; community-level factor; drug development; drug use behavior; experience; follow-up; high risk population; improved; indexing; novel; opioid use disorder; overdose death; overdose risk; polysubstance use; population survey; predictive modeling; psychostimulant; random forest; resilience; social stigma; stimulant use; substance use; traumatic event; young adult

PROJECT ABSTRACT This overdose epidemic in the United States (US) is evolving, and adequate understanding of the behavioral patterns of polysubstance use is critical. Polysubstance use occurs frequently with both prescription and recreational psychoactive drugs. However, patterns of current polysubstance use have not been evaluated in the general population. Delineating the nature of the behavior can help shift focus beyond opioids for combating this epidemic. This research will utilize an existing nationally representative drug survey (~60,000 respondents per year) and conduct a new follow-up polysubstance survey surrounding personal experiences in life relevant to drug use. The overall objective of this research will be to better understand today’s polysubstance use behaviors among the general population. We will do this in three ways. First, present-day behavioral patterns of polysubstance users in the general population will be characterized using latent class analysis to define unique behavioral risk profiles and quantity their prevalence. Second, critical time points in drug behavior progression will be explored. Among current drug users completing the follow-up survey, a latent profile analysis to characterize the trajectories, or profiles, which characterize drug use will be evaluated. Finally, this research will integrate upstream factors such as interpersonal, community, and societal level factors measured on the follow-up survey. This research will be the first to quantify the prevalence of these factors and incorporate them into a predictive model to classify polysubstance use based on a person’s life experiences and not their drug use directly. Finding meaningful and impactful points of intervention is key to effectively reducing the health risks associated with polysubstance use in the future. This approach addresses the evolving drug overdose epidemic by quantifying the complexities of substance use disorders among the general population, delineating the profiles of changing risk across the life span to find opportunities for intervention, and evaluating the predictive value of upstream factors for classifying polysubstance use. The information gleaned from this project can be leveraged -for real-world interventions.

项目摘要 这种在美国(US)的过量流行正在演变，并对行为 多物质的使用模式至关重要。多物质使用经常发生在处方药和 娱乐精神活性药物。然而，目前多物质的使用模式尚未在#年进行评估。 普通民众。描述行为的性质有助于将注意力从阿片类药物转移到 抗击这一流行病。这项研究将利用现有的具有全国代表性的药物调查(~60,000 每年的受访者)，并围绕个人经历进行一项新的后续多物质调查 与吸毒有关的生命。这项研究的总体目标将是更好地理解当今的 一般人群中的多物质使用行为。我们将通过三种方式做到这一点。第一，现在 将使用潜在类别来描述普通人群中多物质使用者的行为模式 分析以定义独特的行为风险概况并量化其流行率。第二，关键时间点 将探索药物行为的进展。在完成跟踪调查的当前吸毒者中，潜在的 将对描述药物使用特征的轨迹或轮廓进行轮廓分析。 最后，这项研究将整合上游因素，如人际、社区和社会层面 在后续调查中测量的因素。这项研究将首次量化这些疾病的流行程度。 并将它们合并到预测模型中，以根据个人的生活对多种物质的使用进行分类 而不是直接吸毒。找到有意义和有影响力的干预点是 有效地减少与未来使用多物质相关的健康风险。这种方法解决了 通过量化药物使用障碍的复杂性来演变药物过量流行 普通人群，描绘了在整个生命周期中不断变化的风险的概况，以寻找 干预，并评估上游因素对多物质使用分类的预测价值。这个 从这个项目收集的信息可以用于现实世界的干预。