Polysubstance Drug Use in the General Population: Present Day Behaviors, Critical Windows, and Predictors of Psychoactive Drug Use

普通人群中的多物质药物使用：当今行为、关键窗口和精神活性药物使用的预测因素

• 批准号: 10572647
• 负责人: Karilynn Rockhill
• 金额: $ 3.16万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10572647
• 关键词: Address; Adult; Age; Behavior; Behavioral; Benzodiazepines; Caring; Cessation of life; Classification; Communities; Complex; Data Sources; Death Rate; Diagnosis; Dimensions; Drug abuse; Drug usage; Drug user; Epidemic; Family; Future; General Population; Glean; Goals; Health; Health Services Accessibility; Healthcare; Individual; Insurance Coverage; Intervention; Law Enforcement; Life; Life Experience; Longevity; Measures; Medical; Mental Health; Nature; Opioid; Overdose; Pattern; Peer Pressure; Persons; Pharmaceutical Preparations; Population; Predictive Factor; Predictive Value; Prevalence; Prevention; Psyche structure; Psychotropic Drugs; Public Health; Recording of previous events; Recreation; Recreational Drugs; Research; Respondent; Risk; Risk Factors; Societal Factors; Substance Abuse Detection; Substance Use Disorder; Surveys; Testing; Time; United States; Work; community-level factor; drug development; drug use behavior; experience; follow-up; high risk population; improved; indexing; novel; opioid use disorder; overdose death; overdose risk; polysubstance use; population survey; predictive modeling; psychostimulant; random forest; resilience; social stigma; stimulant use; substance use; traumatic event; young adult

PROJECT ABSTRACT This overdose epidemic in the United States (US) is evolving, and adequate understanding of the behavioral patterns of polysubstance use is critical. Polysubstance use occurs frequently with both prescription and recreational psychoactive drugs. However, patterns of current polysubstance use have not been evaluated in the general population. Delineating the nature of the behavior can help shift focus beyond opioids for combating this epidemic. This research will utilize an existing nationally representative drug survey (~60,000 respondents per year) and conduct a new follow-up polysubstance survey surrounding personal experiences in life relevant to drug use. The overall objective of this research will be to better understand today’s polysubstance use behaviors among the general population. We will do this in three ways. First, present-day behavioral patterns of polysubstance users in the general population will be characterized using latent class analysis to define unique behavioral risk profiles and quantity their prevalence. Second, critical time points in drug behavior progression will be explored. Among current drug users completing the follow-up survey, a latent profile analysis to characterize the trajectories, or profiles, which characterize drug use will be evaluated. Finally, this research will integrate upstream factors such as interpersonal, community, and societal level factors measured on the follow-up survey. This research will be the first to quantify the prevalence of these factors and incorporate them into a predictive model to classify polysubstance use based on a person’s life experiences and not their drug use directly. Finding meaningful and impactful points of intervention is key to effectively reducing the health risks associated with polysubstance use in the future. This approach addresses the evolving drug overdose epidemic by quantifying the complexities of substance use disorders among the general population, delineating the profiles of changing risk across the life span to find opportunities for intervention, and evaluating the predictive value of upstream factors for classifying polysubstance use. The information gleaned from this project can be leveraged -for real-world interventions.

项目摘要 这种过量的流行病在美国（US）正在演变，并充分了解行为 多种物质的使用模式至关重要。多物质使用经常发生在处方和 娱乐性精神药物然而，目前的多物质使用模式尚未得到评估， 普通民众。描述行为的性质可以帮助将焦点转移到阿片类药物之外， 抗击这一流行病。这项研究将利用现有的全国代表性药物调查（约60，000 并围绕个人经历进行一项新的后续多物质调查， 与吸毒有关的生活。这项研究的总体目标是更好地了解今天的 在一般人群中的多物质使用行为。我们将通过三种方式做到这一点。第一，现代 一般人群中多种物质使用者的行为模式将使用潜在类别来表征 分析，以确定独特的行为风险概况和量化其患病率。第二，关键时间点 将探索药物行为进展。在完成后续调查的现有吸毒者中， 将评价用于描述药物使用轨迹或特征的特征分析。 最后，本研究将整合上游因素，如人际、社区和社会层面 在后续调查中测量的因素。这项研究将是第一个量化这些疾病的患病率的研究。 因素，并将其纳入预测模型，根据一个人的生活对多种物质的使用进行分类 而不是直接使用药物。找到有意义和有影响力的干预点是关键， 有效地减少与未来使用多种物质有关的健康风险。这种方法解决 通过量化药物使用障碍的复杂性， 一般人群，描绘整个生命周期中不断变化的风险概况，以寻找机会， 干预，并评估上游因素对多种物质使用分类的预测价值。的 从该项目中收集的信息可用于现实世界的干预。