Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease

治疗早发性阿尔茨海默病的行为干预措施

• 批准号: 10571346
• 负责人: Dustin Hammers
• 金额: $ 16.83万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10571346
• 关键词: Adherence; Aftercare; Aggressive course; Alzheimer' s Disease; Alzheimer' s disease test; Amyloid; Behavior Therapy; Biometry; Classification; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Cohort Studies; Complement; Data; Development Plans; Diagnosis; Disease; Early Diagnosis; Early Onset Alzheimer Disease; Early treatment; Educational workshop; Ensure; Environment; Exercise; Family; Funding; Future; Goals; Health Personnel; Healthcare; Height; Hour; Impaired cognition; Indiana; Individual; Institution; Intervention; Intervention Trial; Investigation; Knowledge; Learning; Life; Literature; Longitudinal Studies; Mentors; Mission; Modeling; Monitor; Moods; National Institute on Aging; Nature; Nerve Degeneration; Neurodegenerative Disorders; Occupational; Outcome; Outcome Assessment; Participant; Patients; Policies; Population; Positioning Attribute; Psychosocial Factor; Randomized; Research; Research Personnel; Sample Size; Sampling; Scientist; Series; Severities; Severity of illness; Site; Tai Ji; Testing; Training; Training Programs; Underserved Population; United States National Institutes of Health; Universities; Visit; Woman; Work; active control; active control group; aged; career; career development; cognitive change; cognitive training; cohort; comparison control; computerized; exercise intervention; exercise program; experience; feasibility testing; follow-up; improved; improved outcome; lifestyle intervention; men; mid-career faculty; operation; participant retention; patient engagement; patient oriented; pharmacologic; pilot test; primary outcome; programs; rare condition; response; statistics; success; treatment arm; treatment response

PROJECT SUMMARY/ABSTRACT This is a K23 application for Dr. Dustin Hammers, Associate Professor and neuropsychologist at Indiana University pursuing patient-oriented clinical research on lifestyle interventions in Early-Onset Alzheimer’s Disease (EOAD). This K23 will provide him the means to strategically transition from clinician to independent investigator through targeted coursework, didactics and workshops, and career products. The candidate’s supportive and successful institutional environment ensures that the formal career development plan will add to his existing expertise in neurodegenerative disease. His long-term career goal is to become an independent clinician-scientist with an externally funded research program that will enhance behavioral treatment options for patients with EOAD. Despite expansion of research on interventions for Alzheimer’s disease (AD), treatment for patients diagnosed at a younger stage of life has been overlooked, due to the rareness of the condition and challenges identifying disease modifying treatments in traditional-onset AD. These patients experience a unique set of complications related to personal and occupational functioning, including cognitive declines while raising families and performing at the height of their careers. Identification of successful treatments for this condition would lead to significant improvements for patients and their families across multiple aspects of life. The purpose of this 5-year research plan is to collect preliminary data through an NIH-defined Stage IB (NIH Stage Model) study to investigate the feasibility and pilot testing of a lifestyle intervention on short-term and long-term cognition, functioning, and mood in participants with EOAD. Specific Aim 1 will evaluate the feasibility of a lifestyle intervention combining cognitive training and Tai Chi in participants with EOAD, testing the hypotheses that the experimental and active control groups will have comparable attrition rates, and that the combined intervention will be well-tolerated. Specific Aim 2 will investigate if this intervention improves cognitive, functional, and mood outcomes in participants with EOAD compared to an active control condition. It is hypothesized that participants undergoing intervention will perform better on outcomes compared to control participants both post-treatment and at 6-months follow-up. Specific Aim 3 will examine if training or clinical variables moderate benefit from this combined lifestyle intervention. It will explore whether a greater treatment response will be seen in women with EOAD relative to men, and if better response will be related to increased hours of training and decreased disease severity. Outcome improvement from this lifestyle intervention would enhance the personal/occupational functioning of patients with EOAD, have implications for healthcare practice, policy, and clinical trials, and inform this intervention for all forms of AD. The candidate’s training in advanced neurodegeneration, AD trial operations, biostatistical approaches, and career development will complement his research plan, preparing him for future R01 submissions to more formally test this combined intervention and consider additional aspects of this intervention’s benefit in EOAD (transfer of benefit, etc.).

项目总结/摘要 这是印第安纳州的副教授和神经心理学家Dustin Hammers博士的K23应用程序 大学致力于以患者为导向的临床研究，探讨早发性阿尔茨海默病的生活方式干预措施 疾病（EOAD）。这个K23将为他提供从临床医生到独立医生的战略转型手段。 通过有针对性的课程、教学法和讲习班以及职业产品，为调查人员提供培训。候选人的 支持性和成功的体制环境确保正式的职业发展计划将增加 他在神经退行性疾病方面的专业知识他的长期职业目标是成为一名独立的 临床科学家与外部资助的研究计划，将提高行为治疗的选择， EOAD患者。尽管对阿尔茨海默病（AD）干预措施的研究有所扩展，但治疗 由于这种疾病的罕见性， 在传统发病的AD中确定疾病修饰治疗的挑战。这些患者经历了 与个人和职业功能相关的一系列独特并发症，包括认知能力下降， 养家糊口，在事业的巅峰时期表演确定成功的治疗方法 病情将导致患者及其家人在生活的多个方面得到显着改善。 这项5年研究计划的目的是通过NIH定义的阶段IB收集初步数据 (NIH阶段模型）研究，调查短期生活方式干预的可行性和试点测试 以及EOAD参与者的长期认知、功能和情绪。具体目标1将评估 在EOAD参与者中结合认知训练和太极拳的生活方式干预的可行性，测试 假设实验组和活性对照组的损耗率相当， 联合干预的耐受性良好。具体目标2将调查这种干预是否有所改善 与主动控制条件相比，EOAD参与者的认知、功能和情绪结果。它 假设与对照组相比，接受干预的参与者在结果上表现更好 治疗后和6个月随访时的参与者。具体目标3将检查培训或临床 变量中度受益于这种综合生活方式干预。它将探讨是否更好的治疗方法 相对于男性，在EOAD女性中观察到反应，如果反应更好，则与增加 训练时间和降低疾病严重程度。这种生活方式干预的结果改善将 增强EOAD患者的个人/职业功能，对医疗保健有影响 实践，政策和临床试验，并为所有形式的AD提供这种干预措施。候选人的培训 先进的神经变性，AD试验操作，生物统计方法，和职业发展将 补充他的研究计划，为将来的R 01提交做好准备，以更正式地测试这一组合 在EOAD中考虑这种干预的益处的其他方面（益处的转移等）。