Behavioral Interventions for the Treatment of Early Onset Alzheimer's Disease

治疗早发性阿尔茨海默病的行为干预措施

• 批准号: 10571346
• 负责人: Dustin Hammers
• 金额: $ 16.83万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10571346
• 关键词: Adherence; Aftercare; Aggressive course; Alzheimer' s Disease; Alzheimer' s disease test; Amyloid; Behavior Therapy; Biometry; Classification; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Cohort Studies; Complement; Data; Development Plans; Diagnosis; Disease; Early Diagnosis; Early Onset Alzheimer Disease; Early treatment; Educational workshop; Ensure; Environment; Exercise; Family; Funding; Future; Goals; Health Personnel; Healthcare; Height; Hour; Impaired cognition; Indiana; Individual; Institution; Intervention; Intervention Trial; Investigation; Knowledge; Learning; Life; Literature; Longitudinal Studies; Mentors; Mission; Modeling; Monitor; Moods; National Institute on Aging; Nature; Nerve Degeneration; Neurodegenerative Disorders; Occupational; Outcome; Outcome Assessment; Participant; Patients; Policies; Population; Positioning Attribute; Psychosocial Factor; Randomized; Research; Research Personnel; Sample Size; Sampling; Scientist; Series; Severities; Severity of illness; Site; Tai Ji; Testing; Training; Training Programs; Underserved Population; United States National Institutes of Health; Universities; Visit; Woman; Work; active control; active control group; aged; career; career development; cognitive change; cognitive training; cohort; comparison control; computerized; exercise intervention; exercise program; experience; feasibility testing; follow-up; improved; improved outcome; lifestyle intervention; men; mid-career faculty; operation; participant retention; patient engagement; patient oriented; pharmacologic; pilot test; primary outcome; programs; rare condition; response; statistics; success; treatment arm; treatment response

PROJECT SUMMARY/ABSTRACT This is a K23 application for Dr. Dustin Hammers, Associate Professor and neuropsychologist at Indiana University pursuing patient-oriented clinical research on lifestyle interventions in Early-Onset Alzheimer’s Disease (EOAD). This K23 will provide him the means to strategically transition from clinician to independent investigator through targeted coursework, didactics and workshops, and career products. The candidate’s supportive and successful institutional environment ensures that the formal career development plan will add to his existing expertise in neurodegenerative disease. His long-term career goal is to become an independent clinician-scientist with an externally funded research program that will enhance behavioral treatment options for patients with EOAD. Despite expansion of research on interventions for Alzheimer’s disease (AD), treatment for patients diagnosed at a younger stage of life has been overlooked, due to the rareness of the condition and challenges identifying disease modifying treatments in traditional-onset AD. These patients experience a unique set of complications related to personal and occupational functioning, including cognitive declines while raising families and performing at the height of their careers. Identification of successful treatments for this condition would lead to significant improvements for patients and their families across multiple aspects of life. The purpose of this 5-year research plan is to collect preliminary data through an NIH-defined Stage IB (NIH Stage Model) study to investigate the feasibility and pilot testing of a lifestyle intervention on short-term and long-term cognition, functioning, and mood in participants with EOAD. Specific Aim 1 will evaluate the feasibility of a lifestyle intervention combining cognitive training and Tai Chi in participants with EOAD, testing the hypotheses that the experimental and active control groups will have comparable attrition rates, and that the combined intervention will be well-tolerated. Specific Aim 2 will investigate if this intervention improves cognitive, functional, and mood outcomes in participants with EOAD compared to an active control condition. It is hypothesized that participants undergoing intervention will perform better on outcomes compared to control participants both post-treatment and at 6-months follow-up. Specific Aim 3 will examine if training or clinical variables moderate benefit from this combined lifestyle intervention. It will explore whether a greater treatment response will be seen in women with EOAD relative to men, and if better response will be related to increased hours of training and decreased disease severity. Outcome improvement from this lifestyle intervention would enhance the personal/occupational functioning of patients with EOAD, have implications for healthcare practice, policy, and clinical trials, and inform this intervention for all forms of AD. The candidate’s training in advanced neurodegeneration, AD trial operations, biostatistical approaches, and career development will complement his research plan, preparing him for future R01 submissions to more formally test this combined intervention and consider additional aspects of this intervention’s benefit in EOAD (transfer of benefit, etc.).

项目摘要/摘要 这是印第安纳大学副教授兼神经心理学家达斯汀·哈默斯博士的K23申请表 大学开展早发性阿尔茨海默病生活方式干预的临床研究 疾病(Eoad)。K23将为他提供从临床医生到独立医生的战略性过渡手段 通过有针对性的课程作业、教学和研讨会以及职业产品，成为调查人员。候选人的 支持性和成功的体制环境确保正式的职业发展计划将增加 他在神经退行性疾病方面的现有专业知识。他的长期职业目标是成为一名独立的 临床医生-科学家，拥有外部资助的研究计划，将增强行为治疗选择 患有Eoad的患者。尽管对阿尔茨海默病(AD)的干预研究不断扩大，但治疗 对于在生命的年轻阶段被诊断的患者，由于这种情况的罕见和 在传统发病的阿尔茨海默病中确定疾病修改治疗的挑战。这些患者经历了一种 与个人和职业功能有关的一组独特的并发症，包括认知能力下降 在他们事业的巅峰时期养家糊口和表演。确定成功的治疗方法 病情将在生活的多个方面为患者及其家人带来显著改善。 这项为期5年的研究计划的目的是通过NIH定义的阶段IB收集初步数据 (NIH Stage Model)研究调查短期生活方式干预的可行性和试点测试 以及Eoad参与者的长期认知、功能和情绪。特定目标1将评估 认知训练和太极拳相结合的生活方式干预对受试者的可行性 假设试验组和积极控制组将有类似的流失率，并且 联合干预将得到很好的容忍。具体目标2将调查这一干预措施是否有所改善 Eoad患者与积极对照患者的认知、功能和情绪结果比较。它 假设接受干预的参与者在结果上会比对照组表现得更好 参与者在治疗后和6个月的随访中。具体目标3将检查培训或临床 变量适度受益于这种综合的生活方式干预。它将探索是否有更好的治疗方法 与男性相比，患有Eoad的女性会有更好的反应，如果更好的反应与增加有关 几个小时的训练和降低疾病的严重性。这种生活方式干预的结果改善将 增强Eoad患者的个人/职业功能，对医疗保健有影响 实践、政策和临床试验，并告知所有形式的AD的干预措施。应聘者的训练 高级神经变性、AD试验操作、生物统计学方法和职业发展将 补充他的研究计划，让他为未来的R01提交做好准备，以便更正式地测试这一组合 并在Eoad中考虑这种干预的好处的其他方面(利益转移等)。