Energy expenditure, cognitive function, and biomarker features of Alzheimer's disease
阿尔茨海默病的能量消耗、认知功能和生物标志物特征
基本信息
- 批准号:10572262
- 负责人:
- 金额:$ 12.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-15 至 2027-12-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer’s disease biomarkerAmyloidBaltimoreBiologicalBiological MarkersBrainCerebrovascular CirculationClinical ResearchCognitionCognitiveCognitive agingDataDementiaDevelopmentDevelopment PlansDiagnosticDimensionsDiseaseDisease ProgressionElderlyEnergy MetabolismExerciseGeneticGenotypeGoalsImpaired cognitionIndividualInterventionKnowledgeLife StyleLinkLiteratureLongitudinal StudiesMagnetic Resonance ImagingMeasuresMediatingMentored Patient-Oriented Research Career Development AwardMentored Research Scientist Development AwardMentorshipMitochondriaMuscle MitochondriaMusculoskeletal SystemOutcomeOxygenPharmaceutical PreparationsPhysical activityPhysiologicalPositron-Emission TomographyPredictive ValuePublishingResearchResearch PersonnelResearch ProposalsResearch TrainingRestRiskRisk AssessmentRisk ReductionRoleSkeletal MuscleSpecificityStatistical Data InterpretationTechniquesTherapeuticTimeTrainingTranslational ResearchWalkingWorkapolipoprotein E-4brain volumecardiorespiratory fitnesscareercareer developmentcerebral atrophycognitive changecognitive functioncognitive performancecohortcosteducational atmospherehippocampal atrophyinsightlifestyle factorsmild cognitive impairmentneuroimagingnovelprogramsprospectiveresearch studyresponsible research conductsexskillsspecific biomarkerstau Proteinstau aggregationwalking speed
项目摘要
PROJECT SUMMARY / ABSTRACT
This is an application for a Mentored Patient-Oriented Research Career Development Award (K01). The goal of
the proposed project is to provide the candidate with advanced skills necessary to develop an independent
research program focused on the association between physical activity and cognitive decline and dementia,
particularly as it pertains to Alzheimer disease-related dementias (ADRDs). To facilitate this long-term career
goal the candidate will: focus on two physical activity-related measures of energy expenditure (“energetics”) (1)
cardiorespiratory fitness and (2) the energetic cost of walking, as objective markers of the physiological
consequences of habitual physical activity. Recent published work by the candidate suggests that measures of
energetics may optimally capture the physiological mechanisms underlying the beneficial effects of physical
activity on risk for cognitive decline. This research indicates that lower levels of cardiorespiratory fitness –the
integrated ability to deliver oxygen to the musculoskeletal system during sustained activity– is associated with
cognitive decline, increased rate of brain atrophy, and decreased resting cerebral blood flow and that a higher
energetic cost of walking –the oxygen needed for customary paced walking– is associated with increased odds
of amyloid positivity and accelerated hippocampal and brain atrophy. This application proposes a longitudinal
study to i) investigate the extent to which changes in energetics track with changes in cognition and AD
biomarkers, ii) assess which modifiable energetic measure may hold the greatest predictive value with respect
to the forgoing outcomes; and iii) investigate mitochondrial function as a potential underlying biological
mechanism of energetics-brain associations. With a transdisciplinary mentorship team, the applicants career
development plan builds on his previous research training to gain proficiency in: 1) advanced neuroimaging
techniques, using PET and MRS, 2) physical activity-related measures of energy expenditure and post-exercise
MRS assessment of oxidative capacity (a correlate of mitochondrial function), 3) cognitive changes associated
with aging and ADRD, 4) longitudinal statistical analysis, 5) professional development, and 6) responsible
conduct of research. The research objectives and training goals of this K01 award will provide a learning
environment to advance the applicants knowledge in cognitive aging and ADRD and facilitate his transition to an
independent investigator examining the impact of modifiable lifestyle activities on cognitive decline in older
persons.
项目摘要/摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ryan James Dougherty其他文献
Ryan James Dougherty的其他文献
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{{ truncateString('Ryan James Dougherty', 18)}}的其他基金
Longitudinal Assessment of Physical Activity, Cerebral Glucose Metabolism, and Cognitive Function in an At-risk Cohort
高危人群体力活动、脑葡萄糖代谢和认知功能的纵向评估
- 批准号:
9793992 - 财政年份:2018
- 资助金额:
$ 12.61万 - 项目类别:
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