Mobile health applications in adolescent marijuana use: assessing the interplay among sleep, pain and inhibitory control

青少年大麻使用中的移动健康应用：评估睡眠、疼痛和抑制控制之间的相互作用

• 批准号: 10571126
• 负责人: Joe Kossowsky
• 金额: $ 17.9万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10571126
• 关键词: Adolescence; Adolescent; Adolescent Risk Behavior; Adolescent marijuana use; Age; Alcohols; Area; Assessment tool; Award; Behavior; Cannabis; Cellular Phone; Characteristics; Childhood; Cognitive; Collection; Complement; Complex; Data; Data Reporting; Development; Dimensions; Drowsiness; Early Intervention; Ecological momentary assessment; Environment; Event; Frequencies; Funding; Goals; Grant; Health; Health Technology; Impulsivity; Individual; Informatics; Interruption; Intervention; K-Series Research Career Programs; Life; Link; Maps; Marijuana; Measurement; Mediating; Mental Health; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Mobile Health Application; Modeling; Outcome; Pain; Patient Self-Report; Patients; Phenotype; Polysomnography; Population; Positioning Attribute; Process; Protocols documentation; Randomized, Controlled Trials; Reporting; Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Risk Reduction; Risk Taking; Sampling; Severities; Sleep; Sleep Disorders; Sleep disturbances; Stream; Techniques; Technology; Teenagers; Time; Training; United States; Youth; actigraphy; adolescent alcohol abuse; adolescent health; adolescent patient; adolescent substance abuse; adolescent substance use; career; chronic pain; chronic pain patient; circadian; circadian biology; cognitive testing; digital; executive function; health assessment; high risk; mHealth; marijuana use; marijuana use disorder; marijuana user; mobile application; neural network; pain perception; pain symptom; patient oriented; preference; prospective; public health priorities; responsible research conduct; sensor technology; sleep pattern; sleep quality; social; substance use; vulnerable adolescent; wearable device

ABSTRACT This Mentored Research Career Development Award (K01) proposal includes a coordinated training plan and research project that will facilitate the candidate's transition to independent investigator at the intersection of adolescent substance use, in particular marijuana use, sleep disturbances and chronic pain. Adolescent marijuana exposure predicts many negative outcomes, particularly for early, heavy users. Chronic pain is an under-recognized, yet highly prevalent adolescent health problem. Evidence suggests that chronic pain potentiates risk factors for substance use, in particular those related to sleep disturbances and diminished inhibitory control. However, the interplay among sleep, pain, and inhibitory control, as it relates to marijuana use in adolescence, remains minimally explored, which is significant given the unique risk for frequent and heavy marijuana use in this population. The proposed research project utilizes mobile health (mHealth) measurement techniques, combining mobile phones and wearable devices, to enhance our understanding of the longitudinal interplay among these mechanisms in patient’s natural settings. The long-term goal of this K01 award is for the candidate to establish an independent research career aimed at developing and implementing mechanistically informed interventions for marijuana use disorders in youth with chronic pain and sleep disturbances using mHealth approaches. To do so, specific short-term training is required in: 1) conducting adolescent substance use research, with a focus on marijuana use; 2) conducting randomized controlled trials; 3) sleep and circadian biology and sleep measurement techniques; 4) the use of mHealth technologies and protocols and 5) the responsible conduct of research. Two independent, yet related studies are proposed to characterize the relation among sleep, pain, inhibitory control, and marijuana use in an adolescent chronic pain population. A first study will interrogate a large cross-sectional sample of youth with chronic pain to understand the association that particular pain dimensions (i.e. intensity, frequency and interference) show with marijuana use, both directly and through associations with sleep and inhibitory control. Given the potentially complex interplay among factors, a longitudinal assessment is vital to map the unfolding of pathophysiological processes. The second study will therefore combine ecological momentary assessments, mobile app-based cognitive tests, and passive collection of sleep data to provide time-sensitive and ecologically valid models of the longitudinal interplay among risk factors within the context of the individual’s daily life. Such methods are vital for mapping temporal sequences of events and developing specific interventions to interrupt this perpetual cycle and reduce risks, which will be the goal of a subsequent R01 grant.

摘要 本指导研究职业发展奖（K01）提案包括协调培训计划 和研究项目，这将有助于候选人过渡到独立调查员在 青少年物质使用，特别是大麻使用，睡眠障碍和慢性疼痛的交叉。 青少年接触大麻预示着许多负面结果，特别是对于早期的重度使用者。 慢性疼痛是一个未被充分认识但却非常普遍的青少年健康问题。证据表明 慢性疼痛加重了物质使用的危险因素，特别是与睡眠障碍有关的因素 和抑制性控制减弱。然而，睡眠、疼痛和抑制控制之间的相互作用， 与青春期吸食大麻有关，目前仍很少有人研究，但鉴于大麻的独特性，这一点很重要 在这一人群中频繁和大量使用大麻的风险。 拟议的研究项目利用移动的健康（mHealth）测量技术，结合 移动的手机和可穿戴设备，以加强我们对纵向相互作用的理解， 这些机制在病人的自然环境中。K01奖项的长期目标是让候选人 建立一个独立的研究生涯，旨在开发和实施机械知情 使用mHealth对患有慢性疼痛和睡眠障碍的青少年大麻使用障碍进行干预 接近。要执行此操作， 需要在以下方面进行具体的短期培训：1）对青少年使用药物的情况进行监测， 研究，重点是大麻的使用; 2)进行随机对照试验; 3）睡眠和昼夜节律 生物学和睡眠测量技术; 4）使用mHealth技术和协议; 5） 负责任地进行研究。 两项独立但相关的研究被提出来描述睡眠，疼痛， 抑制控制和大麻使用 在青少年慢性疼痛人群中。第一项研究将询问 对患有慢性疼痛的青少年进行大样本横断面研究，以了解特定疼痛 维度（即强度，频率和干扰）显示大麻的使用，无论是直接还是通过 与睡眠和抑制控制的关系。考虑到各种因素之间潜在的复杂相互作用， 纵向评估对于描绘病理生理过程的展开至关重要。第二项研究将 因此，将联合收割机生态瞬时评估、基于移动的应用程序的认知测试和被动 收集睡眠数据，以提供纵向相互作用的时间敏感且生态有效的模型 在个人日常生活中的风险因素。 这些方法对于绘制事件的时间顺序和制定具体的干预措施至关重要 打破这种无休止的循环，降低风险，这将是后续R01赠款的目标。