Core E: Research Experience and Training Coordination Core (RETCC)

核心 E：研究经验和培训协调核心 (RETCC)

• 批准号: 10570859
• 负责人: Jacqueline MacDonald Gibson
• 金额: $ 11.61万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-20 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10570859
• 关键词: Address; Affect; Arsenic; Bioinformatics; Biological Sciences; Biology; Biomedical Research; Camping; Communication; Communities; Data; Data Analyses; Development; Development Plans; Diabetes Mellitus; Discipline; Educational process of instructing; Engineering; Enrollment; Ensure; Environment; Environment and Public Health; Environmental Engineering technology; Environmental Science; Fertilization; Fostering; Future; Gene Expression; Genes; Goals; Grant; Growth and Development function; Hazardous Waste Sites; Human; Individual; Interdisciplinary Education; Journals; Knowledge; Laboratory Research; Leadership; Maps; Metabolic Diseases; Metabolic dysfunction; Methods; MicroRNAs; North Carolina; Obesity; Occupations; Phenotype; Policy Maker; Program Research Project Grants; Public Health; Research; Risk Assessment; Role; Science; Source; Students; Superfund; Technology Transfer; Toxicology; Training; Translational Research; Translations; Vision; Work; Writing; career; career development; career networking; cohort; community based participatory research; community engagement; contaminated water; data integration; data management; diabetogen; disorder prevention; drinking water; experience; geochemistry; ground water; gut microbiome; improved; knowledge integration; novel; outreach; programs; public health relevance; responsible research conduct; skill acquisition; skills; social; success; training opportunity

ABSTRACT: RESEARCH EXPERIENCE AND TRAINING COORDINATION CORE The Research Experience and Training Coordination Core (RETCC) supports UNC-SRP trainees with a unique training opportunity in public health. Trainees will acquire research skills and translational training surrounding the environmental problems associated with inorganic arsenic (iAs) contamination of groundwater in North Carolina and exposure-related metabolic disorder/diabetes. It provides one-of-a-kind training opportunities to understand the sources of iAs, the relation of iAs levels to geochemical factors in NC, the impact of iAs exposure on various metabolic dysfunction phenotypes, and the role of miRNAs, obesity, gene expression and the gut microbiome as factors that are tied to iAs-induced metabolic dysfunction. The goal of the Research Experience and Training Coordination Core (RETCC) is to promote cross-fertilization of knowledge across biomedical science, environmental science, and engineering disciplines through interdisciplinary training in research translation, community engagement, and data management and analysis. The Core will foster interdisciplinary education of and opportunities for teamwork among our trainees through the following aims: Aim 1. Enrich professional career development and growth of UNC-SRP trainees through professional skill development and cultivation of networking opportunities; Aim 2. Promote cohesive approaches that connect and integrate knowledge obtained from a set of core courses with enrichment opportunities in biomedical research, environmental sciences and engineering, and public health; Aim 3. Foster outreach opportunities for trainees to hone skills in community engagement and research translation; Aim 4. Coordinate opportunities for trainees to obtain skills in 21st century data analysis methods through partnership with the data management and analysis core (DMAC). The RETCC activities directly relate to training that is relevant to the UNC-SRP theme “Identifying novel methods to reduce iAs exposure and elucidating mechanisms underlying iAs-induced metabolic dysfunction with a vision for disease prevention.” It does so by providing critical courses and training opportunities to understand the role of iAs exposure in the environment as a diabetogen in the context of both environmental sciences and biomedical sciences.

摘要：研究经验与培训协调核心 研究经验和培训协调核心（RETCC）支持UNC-SRP学员， 在公共卫生方面的独特培训机会。学员将获得研究技能和翻译培训 围绕与地下水无机砷（iAs）污染相关的环境问题， 在北卡罗来纳州和糖尿病相关代谢紊乱。它提供独一无二的培训 分析了华北地区iAs的来源、iAs含量与地球化学因素的关系、 iAs暴露对各种代谢功能障碍表型的影响，以及miRNAs、肥胖、基因 表达和肠道微生物组作为与iAs诱导的代谢功能障碍相关的因素。的目标 研究经验和培训协调核心（RETCC）旨在促进 跨生物医学科学，环境科学和工程学科的知识， 研究翻译，社区参与和数据管理方面的跨学科培训， 分析.核心将促进跨学科的教育和机会，为我们的学员之间的团队合作 通过以下目标：目标1。丰富UNC-SRP受训人员的职业发展和成长 通过专业技能发展和培养网络机会;目标2.促进凝聚力 将从一系列核心课程中获得的知识与丰富内容相结合的方法 在生物医学研究，环境科学和工程，以及公共卫生的机会;目标3。福斯特 为学员提供外展机会，以磨练社区参与和研究翻译方面的技能;目标4. 通过合作伙伴关系，协调学员获得21世纪世纪数据分析方法技能的机会 数据管理和分析核心（DMAC）。培训和技术合作中心的活动与培训直接相关， 与UNC-SRP主题“确定减少iAs接触的新方法， iAs诱导的代谢功能障碍的潜在机制与疾病预防的愿景。它通过 提供关键课程和培训机会，以了解iAs暴露在环境中的作用 在环境科学和生物医学科学的背景下，它是一种致糖尿病物质。