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Neural and motivational mechanisms of age-related change in emotion regulation

年龄相关情绪调节变化的神经和动机机制

基本信息

批准号：
10573164
负责人：
Tammy English
金额：
$ 57万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10573164
关键词：
Address Adult Affective Age Aging Behavior assessment Behavioral Brain Cicatrix Code Cognitive Cues Data Data Set Decision Making Depressed mood Development Diagnostic Dimensions Disease remission Ecological momentary assessment Elderly Emotional Emotions Ethnic Origin Exhibits Facial Expression Foundations Functional Magnetic Resonance Imaging Goals Image Incentives Individual Individual Differences Influentials Intervention Interview Knowledge Laboratories Lateral Learning Life Maintenance Major Depressive Disorder Matched Group Measures Mediating Mental Depression Mental Health Mental disorders Methods Modeling Motivation Neurobiology Nucleus Accumbens Participant Patient Self-Report Pattern Personal Satisfaction Persons Play Population Prefrontal Cortex Process Protocols documentation Quality of life Recording of previous events Research Rewards Role Sampling Scanning Self-control as a personality trait Source Standardization System Testing Update Variant Ventral Striatum Woman Work age effect age related aging population cognitive control cognitive function cognitive reappraisal design emotion dysregulation emotion regulation emotional experience emotional functioning experience healthy aging human old age (65+)improved individual variation innovation insight meetings middle age neural neural circuit neuroeconomics neuroimaging neuromechanism novel positive emotional state prevent racial diversity recurrent depression response reward processing side effect success therapeutic target trait

项目摘要

PROJECT SUMMARY In the progression from middle to older-age, healthy adults typically experience improvements in their emotional functioning, such as increases in positive emotion and greater expertise in managing emotions. However, not everyone shows these age-related improvements, and the mechanisms that give rise to emotional functioning changes across adulthood are still poorly understood. The primary goal of this project is to examine the critical factors that promote positive emotional development in normative aging, and to test whether depression history might moderate this process as a key trait individual difference marker. To this end, we test our proposed Value- Based Cognitive Control Model of Emotion Regulation in ADulthood (VBCC-MERiAD). The VBCC-MERiAD framework suggests a novel insight: that interactions between reward motivation and cognitive control play a central role in understanding both the normative trajectory of emotional functioning in older adults, and conversely, why and how individuals with depression histories may get “off track”. We focus on effectively upregulating positive emotion, given that older adults prioritize positive emotion goals, and because depression is characterized by blunted reward processing. Our primary hypothesis is that positive emotion regulation (ER) abilities will rely upon the integrity of fronto-striatal circuitry (i.e., activity and connectivity between the lateral prefrontal cortex and nucleus accumbens / ventral striatum). Engagement of this circuit is predicted to reflect the utilization of reward motivation as a means of engaging cognitive control (i.e., to update and maintain ER goals). Across three Specific Aims, we propose to characterize the mechanisms of ER in middle-aged and older adults (35-74), focusing on neural and behavioral indicators of motivation and cognitive control that predict daily emotional functioning, and potential dysregulation in individuals with depression history. To achieve these aims, we will employ a multi-method design involving functional neuroimaging measures, laboratory behavioral assessments, and experience sampling methods. The sample (N=220) will include an ethnically/racially diverse set of adults (66% women) of ages 35-74, equally subdivided into two groups: healthy controls and people with depression histories. A state-of-the art neuroimaging protocol will assess brain activity associated with different ER strategies, and test for linkages with reward-motivated cognitive control. The comprehensive laboratory assessments will include diagnostic interviewing, self-report measures, cognitive functioning batteries, and a standardized ER task with measures of autonomic reactivity and behavioral coding of emotion. The experience sampling protocol will provide a naturalistic, ecologically valid assessment of participants’ emotional experiences, goals and regulatory strategies. The proposed research will dramatically extend our understanding of both normative and dysfunctional age-related change in emotional function, by identifying mechanisms that promote positive ER in late adulthood. In so doing, we will lay the foundation for new interventions to improve quality of life for healthy older adults and preventative therapeutic targets for individuals with depression history.

项目总结