A Novel Spray-On Sensing Platform Technology that Enables Wearable Visual Monitoring of Physiological Data and Environmental Exposure

一种新型喷涂传感平台技术，可实现生理数据和环境暴露的可穿戴视觉监测

• 批准号: 10578579
• 负责人: Justyn Jaworski
• 金额: $ 26.18万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10578579
• 关键词: Acetone; Acute; Address; Adherence; Amines; Binding; Biological Assay; Biomedical Technology; Breath Tests; Ceramics; Chemical Exposure; Chemicals; Chemistry; Clothing; Color; Corrosion; Custom; Data; Dermal; Detection; Development; Devices; Dose; Electronics; Environmental Exposure; Environmental Health; Environmental Risk Factor; Equity; Ethanol; Evaluation; Exposure to; Formulation; Foundations; Gene Expression Profiling; Health; Healthcare; Home; Hydrogen Bonding; Hydrophobic Interactions; Hypersensitivity skin testing; Immune response; In Vitro; Individual; Intention; Ketoses; Ketosis; Lateral; Lead Poisoning; Measures; Mechanics; Metals; Modality; Modeling; Monitor; Motivation; Pathway interactions; Performance; Persons; Physiologic Monitoring; Physiological; Polymers; Population; Privacy; Property; Radiometry; Research; Resistance; Risk; Risk Assessment; Rotation; Safety; Self Perception; Skin; Solvents; Specific qualifier value; Specificity; Stimulus; Surface; Sweat test; System; Technology; Testing; Textiles; Time; Toxicant exposure; UV Radiation Exposure; Ultraviolet Rays; Vertebral column; Visual; Water; Work; adverse outcome; amphiphilicity; biomaterial compatibility; carboxylate; carboxylation; clinical diagnostics; cost; cost effective; design; digital; efficacy evaluation; experience; future implementation; health data; health disparity populations; improved; in vitro testing; innovation; interest; irritation; lead exposure; liquid crystal; literacy; mechanical properties; monomer; novel; point of care; polydiacetylene; polymerization; prevent; resilience; response; sensor; sensor technology; skin irritation; success; surgical mask; technology platform; wearable device; wearable health device; wearable monitor

Abstract Wearable sensing has the potential to transform health care by alerting users about important information regarding their health and potential exposure to environmental risks. Some of the most critical barriers to wearable sensing include the cost, complexity, and reliability. Addressing the first two challenges is particularly important to prevent exacerbation of a digital divide in health between those who have access to technologies and the digital literacy to work them and those that do not. A widely deployable sensing platform technology for improving health and wellness that can equitably reach the population is thus needed. Past successes in point- of-care and at-home sensing, including lateral flow sensors, have demonstrated that simple, robust designs that are customizable to different targets can provide significant value and high reliability without the need for electronic systems. With that motivation, we are developing a spray-on sensor technology to serve as a platform for custom wearable coatings that can be easily interpreted by a color change upon exposure to tailored target stimuli. Our encouraging results recently demonstrated a set of proof-of-concept spray-on sensors formulated with diacetylene-containing amphiphiles that could detect physical stimuli (UV radiation) and different chemical targets depending on the amphiphile head-group chemistry. In the proposed project, we are initiating an iterative development approach to understand and enhance the safety and efficacy of our spray-on sensing formulations. In Aim 1, we will focus our efforts on assessing and improving the mechanical properties of our spray-on coating formulations for improved resistance to abrasion and washing without impacting their target sensitivity. Success of this aim will result in a robust coating that can provided reliable sensing throughout conditions experience in routine daily use. In order to provide an understanding of the biocompatibility of distinct formulations that are to be applied directly to the skin for sweat analysis, in Aim 2 we will conduct multiple complementary tests for skin irritation, permeation, and induction of adverse outcome pathways of skin sensitization. Through this aim we will be able to effectively make risk assessments in order to define appropriate exposure limits and if necessary utilize alternative formulation strategies for any components of concern. In Aim 3 with the dual intention of demonstrating the efficacy and reliability of our spray-on approach for different sensing applications, we will examine distinct spray-on formulations with tailored functional head-group chemistry of the diacetylene- amphiphiles for implementation of sweat analysis for lead poisoning, breath analysis for acetone (ketosis), and UV exposure for radiation dosimetry. These three sensor formulations will operate by applying the distinct spray coating onto the skin, onto a surgical mask, or onto fabric (clothing), respectively. By tuning the sensitivity, dynamic range, and selectivity of the individual spray-on sensor formulations for their specified target of interest, these studies will establish this as a novel platform technology for generating spray-on wearable coatings that are capable of reliably monitoring information important to understanding health and environmental exposure.

摘要