Animal Core

动物中心- Yale MPMOD 总结 肥胖和糖尿病活体模型中的耶鲁代谢表型分析（MPMOD）的总体目标 动物核心是提供最先进的畜牧业，医疗保健，加速检疫和生物安全的住房 以及用于评估和维持提交用于表型分析的小鼠的程序空间。MPMOD动物核心 将继续留在耶鲁动物资源中心（YARC），并将建立在所获得的经验， 来自代谢表型> 10，000只小鼠，作为耶鲁大学小鼠代谢表型中心的动物核心 （MMPC）。精确的表型分型在很大程度上取决于动物受试者的健康状况。稳定的住房和 饲养使可能影响表型结果和再现性的外源因素的影响最小化。 提交给MPMOD的小鼠将与来自微生物多样性来源的队列共享空间。他们作为 以及居住在耶鲁大学殖民地的小鼠，必须保护其免受外源性 剂. MPMOD的研究人员也必须在小鼠到达开始后不久就能接触到它们 表型分析，允许在更年轻的年龄研究动物，并最大限度地减少与表型分析相关的成本。 表型分析过程。为了有效地满足这些要求，动物中心将提供 与以下方面有关的设施和服务：1）进口小鼠，使用风险分层方法进行代谢表型分析; 2)确定每个进口组群的微生物概况（在两周内）; 3）提供稳定的， 在所需的持续时间内， 表型鉴定考试; 4）报告和建议MPMOD客户，核心/次核心董事和MPOD董事 提交小鼠的健康状况，并促进其他潜在适用的服务，以促进 表型分析动物中心还将参与制定/修订MPMOD联盟指南， 动物护理

Animal Core- Yale MPMOD Summary The overall objective of the Yale Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD) Animal Core is to provide state-of-the-art husbandry, health care, expedited quarantine, and biosecure housing and procedure space for assessing and maintaining mice submitted for phenotyping. The MPMOD Animal Core will continue to reside within the Yale Animal Resources Center (YARC) and will build on the experience gained from metabolic phenotyping > 10,000 mice as the Animal Core for Yale’s Mouse Metabolic Phenotyping Center (MMPC). Precise phenotyping depends significantly on the health status of animal subjects. Stable housing and husbandry minimize the influence of exogenous factors that could impact phenotyping results and reproducibility. Mice submitted to the MPMOD will share space with cohorts from microbiologically diverse sources. They, as well as mice housed in resident Yale colonies, must be protected against potential cross-infection by adventitious agents. MPMOD investigators also must have ready access to the mice soon after they arrive to begin phenotyping, allowing animals to be studied at younger ages and minimizing costs associated with the phenotyping process. To address these requirements efficiently and effectively, the Animal Core will provide facilities and services relevant to: 1) importing mice for metabolic phenotyping using a risk stratified approach; 2) determining the microbiological profile of each imported cohort (within two weeks); 3) providing stable, biocontainment housing, husbandry and comprehensive health care for mice for the duration required for the phenotyping exam; 4) reporting and advising MPMOD clients, Core/Sub-Core Directors and MPOD Director on the health status of submitted mice and to facilitate other potentially applicable services available to advance phenotyping. The Animal Core will also participate in developing/revising MPMOD consortium guidelines for animal care.