The role of stroke risk factors in the prevalence of stroke symptoms among Hispanic/Latinx Adults

项目概要/摘要 西班牙裔/拉丁裔成年人的总卒中发生率显著更高，卒中死亡年龄更小， 脑卒中后的神经功能、认知和功能结果比白人更差。识别西班牙裔/拉丁裔 卒中高危成人对于消除卒中和长期卒中中的种族/民族不平等至关重要 成果。 脑卒中无卒中状态问卷是一种新颖且有效的筛查工具，用于识别 通过自我报告中风症状（突然发作）， 单侧无力、单侧麻木、视力丧失、半视丧失、无法理解和无法 沟通）。至少有一种卒中症状可预测总卒中发病率 根据临床和流行病学研究的数据，不考虑其他卒中风险因素。然而，在这方面， 目前的研究只集中在非西班牙裔黑人和白色成年人身上。由于变化， 西班牙裔/拉丁裔成年人中卒中风险因素和健康的社会决定因素的患病率与 其他种族/民族群体中，卒中危险因素与卒中症状之间的关系， 西班牙裔/拉丁裔成年人之间的关系是不确定的。 这一创新项目将解决我们在知识的关键差距之间的关系， 西班牙裔/拉丁裔成年人中卒中危险因素和卒中症状的关系，通过（1）评估 高血压，糖尿病（严重程度和临床控制）和中风症状之间的差异， 遗产组和（2）确定临床，社会经济和社会文化因素解释 西班牙裔/拉丁裔遗传群体之间中风症状的差异。这些目标将通过以下方式实现： 利用先前收集的西班牙裔社区健康参与者中风症状的数据， 研究/研究拉丁美洲人（HCHS/SOL）作为主要研究者的国家心脏，肺和 血液研究所（NHLBI）资助的K 01奖（HL 124391）。HCHS/SOL是一项由NIH资助的前瞻性队列研究， 来自四个地理区域的16，000多名西班牙裔/拉丁裔成年人。本申请 也将有助于NHLBI的战略目标，以解决健康的差距，填补关键 我们对西班牙裔/拉丁裔成年人之间中风风险的理解存在差距， 生物医学劳动力的多样性，通过申请人的支持，拉丁裔调查员，过渡到 独立这些数据将用于通知未来的R 01应用程序，以实施文化定制 信息传递和筛查干预，以识别卒中高风险的西班牙裔/拉丁裔成年人。

PROJECT SUMMARY/ABSTRACT Hispanic/Latinx adults exhibit a significantly greater incidence of total stroke, younger age at stroke mortality, and worse neurologic, cognitive, and functional outcomes post-stroke than Whites. Identifying Hispanic/Latinx adults at high risk of stroke is critical to eliminating racial/ethnic inequities in stroke and long-term stroke outcomes. The Questionnaire for Verifying Stroke-Free Status is as a novel and validated screening tool used to identify individuals at a high risk of incident stroke through the self-report of stroke symptoms (sudden onset of unilateral weakness, unilateral numbness, loss of vision, loss of half-vision, inability to understand, and inability to communicate). Endorsement of at least one stroke symptom is predictive of total stroke incidence irrespective of other stroke risk factors, based on data from clinical and epidemiologic studies. However, current research has focused exclusively on non-Hispanic Black and White adults. Due to variability in the prevalence of stroke risk factors and social determinants of health among Hispanic/Latinx adults compared to other racial/ethnic groups, the relationship between stroke risk factors and stroke symptoms among and between Hispanic/Latinx adults is uncertain. This innovative project will address the critical gaps in our knowledge of the relationship between stroke risk factors and stroke symptoms among Hispanic/Latinx adults by (1) assessing the association between hypertension, diabetes (severity and clinical control) and stroke symptoms and variability across heritage group and (2) determining the clinical, socio-economic and socio-cultural factors explaining differences in stroke symptoms across Hispanic/Latinx heritage groups. These aims will be accomplished by utilizing previously collected data on stroke symptoms among participants of Hispanic Community Health Study/Study of Latinos (HCHS/SOL) as an extension of the Principal Investigator's National Heart, Lung and Blood Institute (NHLBI) funded K01 award (HL124391). The HCHS/SOL is a prospective NIH-funded cohort of over 16,000 Hispanic/Latinx adults of heterogenous heritage from four geographic regions. This application will also contribute to the NHLBI's strategic objectives to address disparities in health by filling crucial gaps in our understanding of stroke risk among and between Hispanic/Latinx adults and by promoting biomedical workforce diversity through the support of the applicant, a Latina investigator, transitioning toward independence. These data will be used to inform future R01 applications to implement culturally tailored messaging and screening interventions to identify Hispanic/Latinx adults at high risk of stroke.