The effects of neural modulation on phonatory function in laryngeal dystonia
神经调节对喉肌张力障碍发声功能的影响
基本信息
- 批准号:10578816
- 负责人:
- 金额:$ 19.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-02-15 至 2026-01-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcousticsAddressAffectAgeAreaAuditoryAwardBody RegionsBrainCharacteristicsClinicalClinical ResearchClinical assessmentsCommunicationCommunication impairmentCross-Over StudiesDataDevelopmentDiseaseDoseDouble-Blind MethodDystoniaEnvironmentFailureFocal DystoniasFrequenciesFunctional disorderGeneral HospitalsGoalsGrantHandHealth OccupationsHealthcareHospitalsImpairmentIndividualInterruptionInterventionInvestigationKnowledgeLaryngeal DiseasesLaryngeal muscle structureLarynxLeftLimb DystoniaLimb structureLinkMassachusettsMeasuresMentorsMethodologyMethodsMotorMotor CortexMotor Evoked PotentialsMovement DisordersMuscleNational Institute on Deafness and Other Communication DisordersNeural InhibitionNeurologicParticipantPatientsPatternPersonsPhonationPositioning AttributePrincipal InvestigatorProductionProtocols documentationQuality of lifeRandomizedRehabilitation therapyResearchResearch PersonnelResearch TrainingResourcesRunningSeveritiesSpasmSpastic DysphoniasSpeechSymptomsTestingThyroarytenoid MuscleTimeTrainingTranscranial magnetic stimulationTranslatingTranslational ResearchTranslationsVoiceVoice DisordersWorkadductcare burdenclinical applicationimprovedinnovationinterdisciplinary approachintervention effectneuralneuroimagingneuromechanismneurophysiologyneuroregulationnext generationnoninvasive brain stimulationnovelpatient orientedpost interventionpre-clinicalrandomized, clinical trialsrepetitive transcranial magnetic stimulationresponders and non-respondersresponsesafety and feasibilitysynergismtraining opportunityvocal cord
项目摘要
Project Summary
This application will provide the Principal Investigator, Dr. Teresa Kimberley, with protected time and
support to (1) accelerate a successful record of mentoring junior investigators; (2) provide research
training to mentees engaged in patient-oriented communication disorder research; (3) enhance
training in assessing voice production and; (4) advance the translation of Dr. Kimberley's ongoing
research on laryngeal dystonia. Dystonia is a group of devastating neurological movement disorders
that can affect any body region. There is no cure or disease-modifying treatment and the
pathophysiology of the disorder remains largely unknown. The most common dystonia affecting the
vocal fold muscles is adductor laryngeal dystonia (AdLD). People with AdLD suffer from a strangled
voice and speech interruption due to involuntary spasms of the thyroarytenoid (TA) muscles. The long-
term goal of this award is to elucidate the pathophysiology of laryngeal dystonia and to develop
sensitive testing and novel interventions to treat the disease. The proposed project builds upon Dr.
Kimberley's cutting-edge work of developing a novel and valid transcranial magnetic stimulation (TMS)
methodology to assess the cortical excitability of the laryngeal motor cortical area. Recent findings have
shown an atypical pattern of brain activation and decreased intracortical inhibition in people with
AdLD. The hypothesis is that a 5-day inhibitory rTMS protocol targeted to the left laryngeal motor
area associated with the TA muscles will increase intracortical inhibition and improve phonatory
function in people with AdLD. Individuals with AdLD will participate in a randomized, double-blinded,
sham-controlled, preliminary trial. The primary tests will include assessments of phonatory function
(Aim 1) and TMS-measured neurophysiology (Aim 2). Factors associated with positive response to the
intervention will also be explored (Aim 3). This project offers a unique opportunity for mentees to train
in clinical and translational research that is at the intersection of corticobulbar neurophysiology, non-
invasive neuromodulation, and clinical assessment of voice disorders. The rich resources at
Massachusetts General Hospital, MGH Institute of Health Professions, and Spaulding Rehabilitation
Hospital provide an outstanding scientific environment to train the next generation of researchers in
an interdisciplinary approach to communication disorders research. This project has the potential to
positively impact people with AdLD by expanding treatment options, improving quality of life and
reducing healthcare burden for people with this disorder. The knowledge gained from the proposed
study will extend to future research to optimize neuromodulatory interventions, explore rTMS as an
adjunct therapy to current treatments, and to determine if rTMS can be translated to other voice
disorders or types of focal dystonia.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Teresa Jacobson Kimberley其他文献
A validated E-field based approach for equalizing stimulator output between different TMS coils
一种基于经验证的电场方法,用于均衡不同经颅磁刺激线圈之间的刺激器输出。
- DOI:
10.1016/j.brs.2024.12.826 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:8.400
- 作者:
Evgenii Kim;Mohammad Daneshzand;Keren Zhu;Sergey Makarov;Teresa Jacobson Kimberley;Dylan Edwards;Netri Pajankar;Tommi Raij;Aapo Nummenmaa - 通讯作者:
Aapo Nummenmaa
Effect of head positioning on TMS intensity: E-field modeling with BEM-FMM and modeling validation
- DOI:
10.1016/j.brs.2023.01.071 - 发表时间:
2023-01-01 - 期刊:
- 影响因子:
- 作者:
Yuchao Wang;William A. Wartman;Alton Miles;Isha Vora;Baothy Huynh;Sergey N. Makaroff;Teresa Jacobson Kimberley - 通讯作者:
Teresa Jacobson Kimberley
Teresa Jacobson Kimberley的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Teresa Jacobson Kimberley', 18)}}的其他基金
DYT1 Genotype- and Phenotype-Specific Brain Circuits in Dystonia
肌张力障碍中 DYT1 基因型和表型特异性脑回路
- 批准号:
10303426 - 财政年份:2021
- 资助金额:
$ 19.49万 - 项目类别:
The effects of neural modulation on phonatory function in laryngeal dystonia
神经调节对喉肌张力障碍发声功能的影响
- 批准号:
10347323 - 财政年份:2021
- 资助金额:
$ 19.49万 - 项目类别:
A Multimodal Assessment of Neurophysiology in Focal Dystonia
局灶性肌张力障碍神经生理学的多模式评估
- 批准号:
9239016 - 财政年份:2017
- 资助金额:
$ 19.49万 - 项目类别:
A Multimodal Assessment of Neurophysiology in Focal Dystonia
局灶性肌张力障碍神经生理学的多模式评估
- 批准号:
9564458 - 财政年份:2017
- 资助金额:
$ 19.49万 - 项目类别:
Pathophysiology of Spasmodic Dysphonia: a TMS study
痉挛性发声障碍的病理生理学:一项 TMS 研究
- 批准号:
8443814 - 财政年份:2012
- 资助金额:
$ 19.49万 - 项目类别:
Pathophysiology of Spasmodic Dysphonia: a TMS study
痉挛性发声障碍的病理生理学:一项 TMS 研究
- 批准号:
8281729 - 财政年份:2012
- 资助金额:
$ 19.49万 - 项目类别:
INTEGRATION OF NEUROIMAGING AND BIOMECHANICS OF LOW BACK PAIN
腰痛的神经影像学和生物力学的整合
- 批准号:
8362836 - 财政年份:2011
- 资助金额:
$ 19.49万 - 项目类别:
INTEGRATION OF NEUROIMAGING AND BIOMECHANICS OF LOW BACK PAIN
腰痛的神经影像学和生物力学的整合
- 批准号:
8170441 - 财政年份:2010
- 资助金额:
$ 19.49万 - 项目类别:
EFFECT OF AEROBIC EXERCISE ON BRAIN ACTIVITY FOLLOWING TRAUMATIC BRAIN INJURY
有氧运动对脑外伤后大脑活动的影响
- 批准号:
7954954 - 财政年份:2009
- 资助金额:
$ 19.49万 - 项目类别:
INTEGRATION OF NEUROIMAGING AND BIOMECHANICS OF LOW BACK PAIN
腰痛的神经影像学和生物力学的整合
- 批准号:
7954975 - 财政年份:2009
- 资助金额:
$ 19.49万 - 项目类别:
相似海外基金
Nonlinear Acoustics for the conditioning monitoring of Aerospace structures (NACMAS)
用于航空航天结构调节监测的非线性声学 (NACMAS)
- 批准号:
10078324 - 财政年份:2023
- 资助金额:
$ 19.49万 - 项目类别:
BEIS-Funded Programmes
ORCC: Marine predator and prey response to climate change: Synthesis of Acoustics, Physiology, Prey, and Habitat In a Rapidly changing Environment (SAPPHIRE)
ORCC:海洋捕食者和猎物对气候变化的反应:快速变化环境中声学、生理学、猎物和栖息地的综合(蓝宝石)
- 批准号:
2308300 - 财政年份:2023
- 资助金额:
$ 19.49万 - 项目类别:
Continuing Grant
University of Salford (The) and KP Acoustics Group Limited KTP 22_23 R1
索尔福德大学 (The) 和 KP Acoustics Group Limited KTP 22_23 R1
- 批准号:
10033989 - 财政年份:2023
- 资助金额:
$ 19.49万 - 项目类别:
Knowledge Transfer Partnership
User-controllable and Physics-informed Neural Acoustics Fields for Multichannel Audio Rendering and Analysis in Mixed Reality Application
用于混合现实应用中多通道音频渲染和分析的用户可控且基于物理的神经声学场
- 批准号:
23K16913 - 财政年份:2023
- 资助金额:
$ 19.49万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
结合辐射声学和超声成像,用于放射治疗的实时指导
- 批准号:
10582051 - 财政年份:2023
- 资助金额:
$ 19.49万 - 项目类别:
Comprehensive assessment of speech physiology and acoustics in Parkinson's disease progression
帕金森病进展中言语生理学和声学的综合评估
- 批准号:
10602958 - 财政年份:2023
- 资助金额:
$ 19.49万 - 项目类别:
The acoustics of climate change - long-term observations in the arctic oceans
气候变化的声学——北冰洋的长期观测
- 批准号:
2889921 - 财政年份:2023
- 资助金额:
$ 19.49万 - 项目类别:
Studentship
Collaborative Research: Estimating Articulatory Constriction Place and Timing from Speech Acoustics
合作研究:从语音声学估计发音收缩位置和时间
- 批准号:
2343847 - 财政年份:2023
- 资助金额:
$ 19.49万 - 项目类别:
Standard Grant
Collaborative Research: Estimating Articulatory Constriction Place and Timing from Speech Acoustics
合作研究:从语音声学估计发音收缩位置和时间
- 批准号:
2141275 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
Standard Grant
Flow Physics and Vortex-Induced Acoustics in Bio-Inspired Collective Locomotion
仿生集体运动中的流动物理学和涡激声学
- 批准号:
DGECR-2022-00019 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
Discovery Launch Supplement