EFFECT OF AEROBIC EXERCISE ON BRAIN ACTIVITY FOLLOWING TRAUMATIC BRAIN INJURY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项建议的目标是通过首次研究脑创伤(TBI)受试者的心肺适能和脑活动之间的关系，建立在康复和神经成像现有知识的基础上。本研究的主要目的是找出脑外伤受试者与正常对照组受试者在工作记忆任务中皮层活动的差异，并确定参加12周有氧运动计划对皮层活动的影响。开展这一研究具有重要的理论意义和现实意义。在理论层面上，这项研究将结合运动科学和神经科学，以加强对心肺健康的遥远影响的理解，而不仅仅是公认的生理影响。从实践和治疗的角度来看，了解有氧运动的好处是否适用于脑损伤的成年人，是否适用于健康和受损的动物和健康的人类群体，最终可能导致有氧训练计划作为脑损伤后认知康复的有效辅助手段在临床上使用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this proposal is to build upon the current knowledge of rehabilitation and neuroimaging by examining for the first time the relationship between cardiorespiratory fitness and brain activity in traumatically brain injured (TBI) human subjects. The primary objectives of this study are to identify differences in the cortical activity of TBI subjects compared to normal control subjects during a working memory task and to ascertain the effect of participating in a 12 week aerobic exercise program on that cortical activity. There is both theoretical and practical significance for conducting this study. On a theoretical level, this study will integrate exercise science and neuroscience to enhance the understanding of the distant effects of cardiorespiratory fitness beyond the commonly acknowledged physiological effects. From a practical and therapeutic perspective, knowing whether the benefits of aerobic exercise already seen within well and impaired animals and healthy human populations applies to brain-injured adults may eventually lead to the clinical use of aerobic training programs as efficacious adjuncts to cognitive rehabilitation following TBI.