Vanderbilt Integrated Center of Excellence in Maternal and Pediatric Precision Therapeutics (VICE-MPRINT)

项目总结

PROJECT SUMMARY Our data building system, EHR2PKPD, is efficient, modular, and designed to evolve. The modules were originally developed using data extracted from the locally-developed EHR system, called StarPanel, at Vanderbilt University Medical Center (VUMC) for adult (non-pregnant) patients. On 11/2/2017, VUMC transitioned to an Epic EHR system and implemented a common data model, Observational Medical Outcomes Partnership (OMOP). Thus, the way data are recorded and the data format at VUMC changed substantially. These changes introduced significant challenges in applying our EHR2PKPD system to generate drug dose data from our current VUMC EHRs. We also recognize the drugs and dosing decisions for pregnant and lactating women and children are often unique. In collaboration with other sites at the Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub, we will make our drug research data building system more widely applicable to other types of EHRs at other institutions. Using two drugs for pregnant and lactating women and two drugs for children, we will test and revise our EHR2PKPD system. We propose to achieve two aims: (1) to establish drug dose data processing and building modules of EHR2PKPD for data extracted from VUMC Epic EHR system; (2) to test and generalize drug dose data processing and building modules of EHR2PKPD for data extracted from non- VUMC EHR system. We will focus on structured data, as structured dose data are useful to perform drug-related research for many drugs, while this task is achievable during this 1-year funding period. Working with unstructured dose data will be the focus of future collaborative research work with other sites at the MPRINT Hub. This work will provide the foundations for developing a maternal and pediatric translational research resource platform, which will ultimately facilitate filling knowledge gap in maternal and pediatric therapy.