Vanderbilt Integrated Center of Excellence in Maternal and Pediatric Precision Therapeutics (VICE-MPRINT)

项目摘要 我们的数据构建系统EHR 2 PKPD是高效的、模块化的，并且旨在不断发展。这些模块是 最初使用从本地开发的EHR系统（称为StarPanel）中提取的数据开发， 范德比尔特大学医学中心（VUMC），用于成人（非妊娠）患者。2017年11月2日，VUMC 过渡到Epic EHR系统，并实施了一个通用数据模型，即观察性医疗 成果伙伴关系。因此，VUMC的数据记录方式和数据格式发生了变化 实质上。这些变化在将我们的EHR 2 PKPD系统应用于 从我们当前的VUMC EHR生成药物剂量数据。我们也认识到药物和剂量 对孕妇、哺乳期妇女和儿童的决定往往是独特的。协同其他 在孕产妇和儿科治疗精确度（MPRINT）中心，我们将使我们的药物 研究数据建设系统更广泛地适用于其他机构的其他类型的EHR。 我们将使用两种用于孕妇和哺乳期妇女的药物以及两种用于儿童的药物来测试和修改我们的 EHR 2 PKPD系统。我们提出两个目标：（1）建立药物剂量数据处理系统， 对从VUMC Epic EHR系统中提取的数据建立EHR 2 PKPD模型; 将EHR 2 PKPD的药物剂量数据处理和构建模块进行了推广， VUMC EHR系统。我们将重点关注结构化数据，因为结构化剂量数据有助于执行 许多药物的药物相关研究，而这项任务在这一年的供资期内是可以实现的。 使用非结构化剂量数据将是未来与其他组织合作研究工作的重点。 在MPRINT Hub的网站。这项工作将为发展一种孕产妇和儿科 转化研究资源平台，这将最终有助于填补知识差距，孕产妇 和儿科治疗

PROJECT SUMMARY Our data building system, EHR2PKPD, is efficient, modular, and designed to evolve. The modules were originally developed using data extracted from the locally-developed EHR system, called StarPanel, at Vanderbilt University Medical Center (VUMC) for adult (non-pregnant) patients. On 11/2/2017, VUMC transitioned to an Epic EHR system and implemented a common data model, Observational Medical Outcomes Partnership (OMOP). Thus, the way data are recorded and the data format at VUMC changed substantially. These changes introduced significant challenges in applying our EHR2PKPD system to generate drug dose data from our current VUMC EHRs. We also recognize the drugs and dosing decisions for pregnant and lactating women and children are often unique. In collaboration with other sites at the Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub, we will make our drug research data building system more widely applicable to other types of EHRs at other institutions. Using two drugs for pregnant and lactating women and two drugs for children, we will test and revise our EHR2PKPD system. We propose to achieve two aims: (1) to establish drug dose data processing and building modules of EHR2PKPD for data extracted from VUMC Epic EHR system; (2) to test and generalize drug dose data processing and building modules of EHR2PKPD for data extracted from non- VUMC EHR system. We will focus on structured data, as structured dose data are useful to perform drug-related research for many drugs, while this task is achievable during this 1-year funding period. Working with unstructured dose data will be the focus of future collaborative research work with other sites at the MPRINT Hub. This work will provide the foundations for developing a maternal and pediatric translational research resource platform, which will ultimately facilitate filling knowledge gap in maternal and pediatric therapy.