Vanderbilt Integrated Center of Excellence in Maternal and Pediatric Precision Therapeutics (VICE-MPRINT)

范德比尔特母婴精准治疗卓越综合中心 (VICE-MPRINT)

• 批准号: 10584120
• 负责人: Leena Choi
• 金额: $ 39.46万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10584120
• 关键词: Academic Medical Centers; Address; Adult; Amoxicillin; Buprenorphine; Child; Childhood; Clinical; Collaborations; Data; Data Set; Dose; Drug Prescriptions; Drug usage; Electronic Health Record; Foundations; Funding; Future; Gold; Indiana; Institution; Knowledge; Label; Lactation; Manuals; Marketing; Medical; Names; Only Child; Outcome; Patients; Pediatric Hospitals; Pharmaceutical Preparations; Pharmacotherapy; Population; Precision therapeutics; Pregnancy; Process; Research; Resources; Site; Source; Structure; System; Testing; Therapeutic; Translational Research; Universities; Vancomycin; Vulnerable Populations; Woman; Work; cohort; computerized data processing; data format; data modeling; design; dose information; drug candidate; drug development; drug efficacy; drug testing; medication safety; pharmacokinetics and pharmacodynamics; pregnant; structured data; tool; unstructured data

PROJECT SUMMARY Our data building system, EHR2PKPD, is efficient, modular, and designed to evolve. The modules were originally developed using data extracted from the locally-developed EHR system, called StarPanel, at Vanderbilt University Medical Center (VUMC) for adult (non-pregnant) patients. On 11/2/2017, VUMC transitioned to an Epic EHR system and implemented a common data model, Observational Medical Outcomes Partnership (OMOP). Thus, the way data are recorded and the data format at VUMC changed substantially. These changes introduced significant challenges in applying our EHR2PKPD system to generate drug dose data from our current VUMC EHRs. We also recognize the drugs and dosing decisions for pregnant and lactating women and children are often unique. In collaboration with other sites at the Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub, we will make our drug research data building system more widely applicable to other types of EHRs at other institutions. Using two drugs for pregnant and lactating women and two drugs for children, we will test and revise our EHR2PKPD system. We propose to achieve two aims: (1) to establish drug dose data processing and building modules of EHR2PKPD for data extracted from VUMC Epic EHR system; (2) to test and generalize drug dose data processing and building modules of EHR2PKPD for data extracted from non- VUMC EHR system. We will focus on structured data, as structured dose data are useful to perform drug-related research for many drugs, while this task is achievable during this 1-year funding period. Working with unstructured dose data will be the focus of future collaborative research work with other sites at the MPRINT Hub. This work will provide the foundations for developing a maternal and pediatric translational research resource platform, which will ultimately facilitate filling knowledge gap in maternal and pediatric therapy.

项目总结 我们的数据构建系统EHR2PKPD是高效的、模块化的，并且旨在不断发展。这些模块是 最初是使用从当地开发的名为StarPanel的EHR系统提取的数据开发的，网址为 范德比尔特大学医学中心(VUMC)为成人(非怀孕)患者提供服务。2017年11月2日，VUMC 过渡到Epic EHR系统，并实施了通用数据模型--观察医学 成果伙伴关系(OMOP)。因此，VUMC的数据记录方式和数据格式发生了变化 基本上是这样的。这些变化带来了将我们的EHR2PKPD系统应用于 从我们目前的VUMC EHR生成药物剂量数据。我们还认识到这些药物和剂量 孕妇、哺乳期妇女和儿童的决定往往是独一无二的。与其他人合作 在母婴精准治疗中心(MPRINT)的网站上，我们将生产我们的药物 研究数据建设系统，更广泛地适用于其他机构的其他类型的电子病历。 使用孕妇和哺乳期妇女的两种药物和儿童的两种药物，我们将测试和修改我们的 EHR2PKPD系统。我们建议实现两个目标：(1)建立药物剂量数据处理和 为从VUMC Epic EHR系统提取的数据建立EHR2PKPD模块；(2)测试和 推广EHR2PKPD的药物剂量数据处理和构建模块 VUMC电子病历系统。我们将重点介绍结构化数据，因为结构化剂量数据在执行时非常有用 许多药物的药物相关研究，而这项任务在这一年的资助期内是可以实现的。 使用非结构化剂量数据将是未来与其他机构合作研究的重点 位于MPRINT中心的站点。这项工作将为发展母儿医学 翻译研究资源平台，最终将有助于填补孕产妇的知识缺口 和儿科治疗。