Vanderbilt Integrated Center of Excellence in Maternal and Pediatric Precision Therapeutics (VICE-MPRINT)
Vanderbilt Integrated Center of Excellence in Maternal and Pediatric Precision Therapeutics (VICE-MPRINT)
批准号:
10584120
负责人:
Leena Choi
金额:
$39.46万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-05-01 至 2024-04-30
关键词:
Academic Medical CentersAddressAdultAmoxicillinBuprenorphineChildChildhoodClinicalCollaborationsDataData SetDoseDrug PrescriptionsDrug usageElectronic Health RecordFoundationsFundingFutureGoldIndianaInstitutionKnowledgeLabelLactationManualsMarketingMedicalNamesOnly ChildOutcomePatientsPediatric HospitalsPharmaceutical PreparationsPharmacotherapyPopulationPrecision therapeuticsPregnancyProcessResearchResourcesSiteSourceStructureSystemTestingTherapeuticTranslational ResearchUniversitiesVancomycinVulnerable PopulationsWomanWorkcohortcomputerized data processingdata formatdata modelingdesigndose informationdrug candidatedrug developmentdrug efficacydrug testingmedication safetypharmacokinetics and pharmacodynamicspregnantstructured datatoolunstructured data
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Our data building system, EHR2PKPD, is efficient, modular, and designed to evolve. The modules were
originally developed using data extracted from the locally-developed EHR system, called StarPanel, at
Vanderbilt University Medical Center (VUMC) for adult (non-pregnant) patients. On 11/2/2017, VUMC
transitioned to an Epic EHR system and implemented a common data model, Observational Medical
Outcomes Partnership (OMOP). Thus, the way data are recorded and the data format at VUMC changed
substantially. These changes introduced significant challenges in applying our EHR2PKPD system to
generate drug dose data from our current VUMC EHRs. We also recognize the drugs and dosing
decisions for pregnant and lactating women and children are often unique. In collaboration with other
sites at the Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub, we will make our drug
research data building system more widely applicable to other types of EHRs at other institutions.
Using two drugs for pregnant and lactating women and two drugs for children, we will test and revise our
EHR2PKPD system. We propose to achieve two aims: (1) to establish drug dose data processing and
building modules of EHR2PKPD for data extracted from VUMC Epic EHR system; (2) to test and
generalize drug dose data processing and building modules of EHR2PKPD for data extracted from non-
VUMC EHR system. We will focus on structured data, as structured dose data are useful to perform
drug-related research for many drugs, while this task is achievable during this 1-year funding period.
Working with unstructured dose data will be the focus of future collaborative research work with other
sites at the MPRINT Hub. This work will provide the foundations for developing a maternal and pediatric
translational research resource platform, which will ultimately facilitate filling knowledge gap in maternal
and pediatric therapy.
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会议论文
System construction for population pharmacokinetic and pharmacodynamic modeling using electronic health records: toward precision medicine
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批准号:9924610
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项目类别:
-
资助金额:$30.75万
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财政年份:2017
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负责人:Leena Choi
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依托单位:
Population Pharmacokinetic and Pharmacodynamic Models in the Presence of Outliers
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批准号:8246401
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项目类别:
-
资助金额:$16.12万
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财政年份:2011
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负责人:Leena Choi
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依托单位:
Population Pharmacokinetic and Pharmacodynamic Models in the Presence of Outliers
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批准号:8114812
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项目类别:
-
资助金额:$20.33万
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财政年份:2011
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负责人:Leena Choi
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依托单位:
海外基金