Cortical Representations of Harmonic and Virtual Pitch in Humans

人类谐波和虚拟音高的皮质表征

• 批准号: 10582772
• 负责人: Anahita H Mehta
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582772
• 关键词: Acoustics; Address; Animal Experimentation; Anterior; Anterolateral; Attention; Auditory; Auditory Prosthesis; Auditory area; Auditory system; Award; Behavior; Behavioral; Characteristics; Cochlear Implants; Code; Complex; Cues; Data; Development; Diffuse; Electrophysiology (science); Frequencies; Functional Magnetic Resonance Imaging; Goals; Hearing; Human; Illusions; Imaging Techniques; Individual; Judgment; Lateral; Maps; Mentors; Modeling; Modification; Music; Myelin; Neurons; Noise; Outcome; Perception; Peripheral; Phase; Pitch Perception; Play; Population; Process; Property; Prosthesis; Psychoacoustics; Reporting; Research; Role; Series; Signal Transduction; Speech; Speech Perception; Stimulus; Techniques; Testing; Training; Work; anatomic imaging; base; density; design; experimental study; hearing impairment; insight; neural correlate; neuroimaging; neurophysiology; normal hearing; novel; perceptual organization; programs; relating to nervous system; response; sound; stem; theories; virtual

1 PROJECT SUMMARY/ABSTRACT 2 Pitch and harmonicity play a defining role in the perception of speech and music, and are crucial for 3 the perceptual organization of sounds in an auditory scene. Listeners with hearing loss, and 4 especially those with cochlear implants, suffer from a striking deficit in pitch perception abilities, as 5 current sound processing strategies are unable to provide robust pitch cues. Despite advances in our 6 understanding of how pitch is perceived, coded, and represented in our auditory system, there are 7 still significant gaps in our basic understanding of how pitch, and especially harmonicity, is 8 represented in the auditory cortex. A better understanding of the neural transformations involved in 9 pitch perception should help in designing more effective neural and acoustic prostheses. The overall 10 goal of the proposed project is to understand the neural representation of pitch and harmonicity and 11 elucidate the role of temporal integration in pitch perception using a combination of behavioral 12 (psychoacoustics), electrophysiology (EEG), and neuroimaging techniques (fMRI). In the mentored 13 K99 phase of this project, the candidate will conduct research on both of these overarching themes. 14 fMRI will be used to investigate what properties of harmonic complex tones are represented in 15 anterior-lateral regions of auditory cortex (Aim 1). Using carefully controlled stimuli, this study should 16 provide strong evidence for whether harmonic tones elicit a stronger response than inharmonic tones 17 in auditory cortex. The candidate will also conduct a series of behavioral experiments using a novel 18 stimulus that produces an illusory virtual pitch percept, to provide empirical data for quantifying the 19 parameters governing temporal integration in the perception of pitch (Aim 2). These behavioral 20 experiments will add crucial understanding of the temporal aspects of pitch perception, which are not 21 taken into account in current pitch perception models. In the R00 phase of the project, the candidate 22 will utilize the techniques and findings of Aims 1 and 2 to study two important aspects of pitch 23 processing and perception. A novel modification of the stimulus investigated in Aim 2 will be utilized in 24 an fMRI study to differentiate the cortical representations of different perceptual modes of listening, 25 namely synthetic and analytic. Additionally, this stimulus will also be used in an EEG study to explore 26 the neural correlates of the Pitch Onset Response (POR). Overall, this project will relate perceptual 27 characterizations of the illusory stimulus to neurophysiological findings to provide new insights to the 28 field of pitch perception, which in turn could motivate the development of novel pitch processing 29 strategies in auditory prostheses. The research performed and training provided during this award will 30 enable the candidate to achieve her goal of developing an independent research program that 31 employs both neurophysiological and behavioral approaches to investigate auditory phenomena.

1项目概要/摘要 2音高和和声在语音和音乐的感知中起着决定性的作用，对于 3听觉场景中声音的知觉组织。听力损失患者，以及 4特别是那些植入人工耳蜗的人，在音高感知能力方面存在明显的缺陷， 当前的声音处理策略不能提供鲁棒的音高提示。尽管我们的技术取得了进步， 6理解音高是如何在我们的听觉系统中被感知、编码和表示的， 7在我们对音高，尤其是和声性的基本理解上， 8在听觉皮层中。更好地理解参与的神经转换 9音高感知应该有助于设计更有效的神经和声学假体。整体 该项目的目标是了解音高和和声的神经表征， 11阐明了时间整合在音高感知中的作用， 12（心理声学）、电生理学（EEG）和神经成像技术（fMRI）。在辅导 13 K99阶段，候选人将对这两个首要主题进行研究。 14功能磁共振成像将被用来调查什么属性的谐波复杂的音调表示在 15个听觉皮层的前外侧区域（Aim 1）。通过仔细控制刺激，这项研究应该 16提供了强有力的证据，是否谐波音调引起更强的反应比非谐波音调 听觉皮层17例。候选人还将使用一本小说进行一系列行为实验 18刺激，其产生虚幻的虚拟音高感知，以提供用于量化音高感知的经验数据。 19个参数支配音高感知中的时间整合（目标2）。这些行为 20个实验将增加对音高感知的时间方面的重要理解，这不是 21在当前的音高感知模型中考虑。在项目的R 00阶段，候选人 22将利用目标1和2的技术和发现来研究音高的两个重要方面 23、认知与思考目标2中研究的刺激的新修改将用于 24一项区分不同听觉感知模式的皮层表征的功能磁共振成像研究， 第25章分析与综合此外，该刺激还将用于EEG研究，以探索 26音高起始反应（POR）的神经相关性。总的来说，这个项目将涉及感性 27表征的错觉刺激的神经生理学研究结果，提供新的见解， 28领域的音高感知，这反过来又可以激发新的音高处理的发展 听觉假体的29种策略。在此奖项期间进行的研究和提供的培训将 30使候选人能够实现她的目标，发展一个独立的研究计划， 31采用神经生理学和行为学方法来研究听觉现象。