Nutrient-dependent regulation of neural stem cell proliferation and neural circuit formation

神经干细胞增殖和神经回路形成的营养依赖性调节

• 批准号: 10581868
• 负责人: Sarah Elizabeth Siegrist
• 金额: $ 1.64万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581868
• 关键词: Alzheimer' s Disease; Animals; Award; Biological Models; Brain; Cells; Development; Diet; Drosophila genus; Drosophila melanogaster; Funding; Genetic; Healthcare Systems; Human; Humidity; Incubators; Laboratories; Malignant Neoplasms; Microcephaly; Molecular; Neurodegenerative Disorders; Neurodevelopmental Disorder; Neurons; Nutrient; Research; Societies; Staging; Temperature; autism spectrum disorder; cost; dietary; experimental study; nerve stem cell; neural circuit; neuronal circuitry; neuroregulation; response; stem cell proliferation

PROJECT SUMMARY We are seeking to acquire supplemental funds to support the purchase of an incubator that will be used in our research that is currently funded by a R35 award. Our current R35 is aimed at uncovering genetic and molecular mechanisms that regulate neural stem cell proliferation decisions in response to dietary nutrient availability and the nutrient-regulated neuronal circuitry that controls these decisions. We use Drosophila melanogaster as a model system. In order to use Drosophila in a laboratory setting, a temperature, humidity, and light/dark cycle controlled incubator is needed to house the animals and for developmental staging experiments.

项目摘要 我们正在寻求获得补充资金，以支持购买孵化器， 用于我们目前由R35奖资助的研究中。我们目前的R35旨在 揭示调节神经干细胞增殖的遗传和分子机制 对膳食营养素可用性和营养素调节的神经回路做出反应的决定 控制着这些决定。我们使用果蝇作为模型系统。为了 在实验室环境中使用果蝇，控制温度、湿度和光/暗周期 需要恒温箱来安置动物和进行发育阶段实验。