Nutrient-dependent regulation of neural stem cell proliferation and neural circuit formation

项目摘要 我们正在寻求获得补充资金，以支持购买孵化器， 用于我们目前由R35奖资助的研究。我们目前的R35旨在 揭示调节神经干细胞增殖的遗传和分子机制 对膳食营养素可用性和营养素调节的神经回路做出反应的决定 控制着这些决定。我们使用果蝇作为模型系统。为了 在实验室环境中使用果蝇，控制温度、湿度和光/暗周期 需要恒温箱来安置动物和进行发育阶段实验。

PROJECT SUMMARY We are seeking to acquire supplemental funds to support the purchase of an incubator that will be used in our research that is currently funded by a R35 award. Our current R35 is aimed at uncovering genetic and molecular mechanisms that regulate neural stem cell proliferation decisions in response to dietary nutrient availability and the nutrient-regulated neuronal circuitry that controls these decisions. We use Drosophila melanogaster as a model system. In order to use Drosophila in a laboratory setting, a temperature, humidity, and light/dark cycle controlled incubator is needed to house the animals and for developmental staging experiments.