Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System Equipment Supplement

项目摘要 我们的第一阶段生物研究卓越中心（COBRE）的总体目标是 建立内华达州COBRE在分子和细胞信号转导在心血管 内华达州里诺大学（UNR）和UNR医学院（UNR Med）的系统 作为一个可持续的，专题的，跨学科的基础科学研究中心。这次使命 通过开发和利用最先进的分子，遗传，生物物理和 生物医学成像技术。COBRE包括一个管理核心（核心A） 由项目主任斯科特厄利博士领导，两个研究中心和5个项目负责人。 博士冯玉梅（Yumei Feng）厄利（Earley）是转基因动物基因分型和表型研究中心主任 核心（TAGP，核心B）和Normand Leblanc博士指导高空间和时间分辨率 Imaging Core（HSTRI; Core C），为项目负责人提供访问各种 最先进的仪器，能够对细胞进行高空间和时间分辨率成像， 用荧光指示剂标记的组织样品。眼镜蛇正在申请 响应NOSI NOT-GM-22-017的行政补充，将增强 TAGP核心的能力。本申请的具体目的是购买新的EchoMRI 机这个新系统的价格标签是167500美元。EchoMRI允许非侵入性， 高精度检测活体动物脂肪量、瘦肉量、自由水和总身体水分， 这是TAGP核心目前不具备的能力。随着动物的需求 心血管和代谢表型，该系统将提供新的创新技术， 项目领导人以及该中心和其他UNR生物医学的既定成员 investigators.按照配置，该EchoMRI能够执行精确测量 整个动物的体重范围为25- 500 g。该系统还配备了用于活检的天线/探头 和组织检查。

Project Summary The overall objective of our Phase I Center of Biological Research Excellence (COBRE) is to establish the Nevada COBRE in Molecular and Cellular Signal Transduction in the Cardiovascular System at the University of Nevada, Reno (UNR) and the UNR School of Medicine (UNR Med) as a sustainable, thematic, interdisciplinary basic science research Center. This mission will be accomplished by developing and utilizing state-of-the-art molecular, genetic, biophysical, and biomedical imaging technologies. The COBRE comprises an Administration Core (Core A) headed by the Program Director, Dr. Scott Earley, two Research Cores, and 5 Project Leaders. Dr. Yumei Feng Earley is the Director of the Transgenic Animal Genotyping and Phenotyping Core (TAGP, Core B) and Dr. Normand Leblanc directs the High Spatial and Temporal Resolution Imaging Core (HSTRI; Core C), which provides the Project Leaders with access to a wide array of state-of-the-art instruments enabling high spatial and temporal resolution imaging of cells and tissues samples labeled with fluorescent indicators. The COBRE is submitting an application for an Administrative Supplement in response to NOSI NOT-GM-22-017 that will enhance the capabilities of the TAGP Core. The Specific Aim of this application is to purchase a new EchoMRI machine. The price tag for this new system is $167,500. The EchoMRI allows for a non-invasive, high precision examination of fat-mass, lean-mass, free-water and total body water in live animals, a capability that the TAGP Core currently does not have currently. With the demand of who animal cardiovascular and metabolic phenotyping, this system will provide new innovative techniques to the Project leaders as well as the established members of the center and other UNR biomedical investigators. As configurated, this EchoMRI has the capacity to perform precise measurement of whole animals range from 25-500g. This system is also equipped with antenna/probe for biopsy and tissue examination.