Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System Equipment Supplement

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Project Summary The overall objective of our Phase I Center of Biological Research Excellence (COBRE) is to establish the Nevada COBRE in Molecular and Cellular Signal Transduction in the Cardiovascular System at the University of Nevada, Reno (UNR) and the UNR School of Medicine (UNR Med) as a sustainable, thematic, interdisciplinary basic science research Center. This mission will be accomplished by developing and utilizing state-of-the-art molecular, genetic, biophysical, and biomedical imaging technologies. The COBRE comprises an Administration Core (Core A) headed by the Program Director, Dr. Scott Earley, two Research Cores, and 5 Project Leaders. Dr. Yumei Feng Earley is the Director of the Transgenic Animal Genotyping and Phenotyping Core (TAGP, Core B) and Dr. Normand Leblanc directs the High Spatial and Temporal Resolution Imaging Core (HSTRI; Core C), which provides the Project Leaders with access to a wide array of state-of-the-art instruments enabling high spatial and temporal resolution imaging of cells and tissues samples labeled with fluorescent indicators. The COBRE is submitting an application for an Administrative Supplement in response to NOSI NOT-GM-22-017 that will enhance the capabilities of the TAGP Core. The Specific Aim of this application is to purchase a new EchoMRI machine. The price tag for this new system is $167,500. The EchoMRI allows for a non-invasive, high precision examination of fat-mass, lean-mass, free-water and total body water in live animals, a capability that the TAGP Core currently does not have currently. With the demand of who animal cardiovascular and metabolic phenotyping, this system will provide new innovative techniques to the Project leaders as well as the established members of the center and other UNR biomedical investigators. As configurated, this EchoMRI has the capacity to perform precise measurement of whole animals range from 25-500g. This system is also equipped with antenna/probe for biopsy and tissue examination.