WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research Facilities

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Project Summary/Abstract Parent grant (P51 OD011106). The Wisconsin National Primate Research Center (WNPRC) is one of seven federally funded National Primate Research Centers and the only one in the Midwest. WNPRC's mission is to increase the understanding of basic primate biology and to improve human health and quality of life through research. To accomplish this, the WNPRC helps discover treatments, preventions and cures for human disease; generates new knowledge of primate biology, from the molecular and whole animal levels to the understanding of primate ecosystems; facilitates research progress by providing expertise, resources and training to scientists worldwide; and collects primate information and disseminates to the research community and to the public. Administrative Supplement. The WNPRC supports a large cadre of investigators utilizing the simian immunodeficiency virus (SIV) and the simian/human immunodeficiency virus (SHIV)-infected rhesus and cynomolgus macaque as models of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). In 2019, the WNPRC obtained C06 funding to construct a new infectious disease suite consisting of seven macaque holding rooms, one procedure room engineered to support a variety of procedures commonly performed with SIV/SHIV infected macaques, as well as appropriate husbandry support space. The single, straightforward, specific aim of this P51 administrative supplement proposal is to secure funding to purchase a substantial portion of state-of-the-art mobile “four-bank” nonhuman primate enclosures necessary to equip the new infectious disease suite as the COVID-19 pandemic has greatly reduced the financial reserves the Center planned to utilize to purchase these enclosures.