Purchase and Installation of New Equipment for the WNPRC ABSL-3 Suite

为 WNPRC ABSL-3 套件购买和安装新设备

• 批准号: 10808744
• 负责人: Steven A. Ackerman
• 金额: $ 34.83万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-10 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10808744
• 关键词: Administrative Supplement; Air; Aluminum; Animal Housing; Animals; Autopsy; Award; Biological; Caring; Cercopithecidae; Certification; Collaborations; Colorado; Contracts; Data; Data Science; Decontamination; Digital Radiography; Disease Progression; Disinfectants; Elderly; Electrocardiogram; Engineering; Environment; Equipment; Funding; Grant; Health; Heart; Housing; Human Resources; Hydrogen Peroxide; Individual; Infrastructure; International; Laboratories; Manuals; Medicine; Minor; Modeling; Motor; Primates; Procedures; Process; Quarantine; R24; Recommendation; Recording of previous events; Request for Proposals; Research; Running; Safety; Sampling; Specialist; Speed; Sterilization; Surface; System; Telemetry; Temperature; United States National Institutes of Health; Universities; Validation; Wisconsin; design; equipment acquisition; exhaust; foot; high efficiency particulate air filter; improved; institutional biosafety committee; lung imaging; manufacture; nonhuman primate; pathogen; point of care; pressure; programs; real time monitoring; research clinical testing; respiratory; serial imaging; sound; ultrasound; usability; wasting

Project Summary/Abstract Using funding from two administrative supplements awarded by the NIH Office of Infrastructure Programs, the Wisconsin National Primate Research Center (WNPRC) contracted bioBubble, Inc. (Fort Collins, Colorado) to design, manufacture, and install soft-wall HEPA-filtered enclosures in quarantine rooms 152 and 156 at our Blue Mounds Quarantine Facility. These enclosures contain two Animal Biosafety Level-3 (ABSL-3) housing spaces large enough to hold a total of 44 adult Old World monkeys and an adjacent Biosafety Level-3 procedure/laboratory space large enough to hold a downdraft exam/necropsy table, biosafety cabinet, digital radiography unit, and sample freezers and represent the first functional ABSL-3 suite at the WNPRC in its 61- year history. The specific aims of this administrative supplement request are to purchase the pieces of equipment listed below and to perform minor alterations to the new WNPRC ABSL-3 suite to install this equipment. 1. A Model PT-SR-24C: 24" X 36" X 36" chamber pass-thru sterilizer from Consolidated Sterilizer Systems 2. A Bioquell ProteoQ vaporized hydrogen peroxide decontamination from Ecolab 3. Two Dynaco Streamline high speed doors from Paul Reilly Company 4. Physiotel large animal telemetry system from Data Sciences International 5. Vivid IQ Ultra Pro V204 tabletop ultrasound unit from Sound 6. Fourteen power unit covers from bioBubble Purchasing and installing the equipment listed above will further augment biosafety practices within the suite and will improve the quality of veterinary care performed and data collected from the nonhuman primates housed in the suite.

项目总结/摘要 利用NIH基础设施项目办公室提供的两项行政补充资金， 威斯康星州国家灵长类动物研究中心（WNPRC）与bioBubble，Inc.签约。(Fort柯林斯，科罗拉多） 设计，制造，并在隔离室152和156安装软壁HEPA过滤外壳，在我们的 蓝土丘隔离设施。这些围栏包含两个动物生物安全3级（ABSL-3）住房 足够容纳44只成年旧大陆猴子的空间和邻近的生物安全三级 手术/实验室空间足够大，可容纳向下通风检查/尸检台，生物安全柜，数字 X射线照相装置和样品冷冻机，并代表了第一个功能ABSL-3套房在WNPRC在其61- 年历史。 本行政补充申请的具体目的是购买所列设备 并对新的WNPRC ABSL-3套件进行微小改动，以安装该设备。 1.型号PT-SR-24 C：来自Consolidated Sterilizer的24 "X 36" X 36 "灭菌室直通式灭菌器 系统 2.来自Ecolab的Bioquell ProteoQ汽化过氧化氢去污 3.两扇来自Paul Reilly公司的Dynaco流线型高速门 4.来自Data Sciences International的Physiotel大型动物遥测系统 5. Sound的Vivid IQ Ultra Pro V204台式超声装置 6. bioBubble的14个动力装置盖 购买和安装上述设备将进一步增强套件内的生物安全实践 并将提高兽医护理的质量和从非人类灵长类动物收集的数据 在套房里。

项目成果

Immune transgene-dependent myocarditis in macaques after systemic administration of adeno-associated virus expressing human acid alpha-glucosidase.

• DOI: 10.3389/fimmu.2023.1094279
• 发表时间: 2023
• 期刊: FRONTIERS IN IMMUNOLOGY
• 影响因子: 7.3
• 作者: Hordeaux, Juliette;Ramezani, Ali;Tuske, Steve;Mehta, Nickita;Song, Chunjuan;Lynch, Anna;Lupino, Katherine;Chichester, Jessica A.;Buza, Elizabeth L.;Dyer, Cecilia;Yu, Hongwei;Bell, Peter;Weimer, Jill M.;Do, Hung;Wilson, James M.
• 通讯作者: Wilson, James M.

CAR/CXCR5-T cell immunotherapy is safe and potentially efficacious in promoting sustained remission of SIV infection.

• DOI: 10.1371/journal.ppat.1009831
• 发表时间: 2022-03
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Pampusch MS;Abdelaal HM;Cartwright EK;Molden JS;Davey BC;Sauve JD;Sevcik EN;Rendahl AK;Rakasz EG;Connick E;Berger EA;Skinner PJ
• 通讯作者: Skinner PJ

Systemic administration of 6-OHDA to rhesus monkeys upregulates HLA-DR expression in brain microvasculature.

全系统地给予6-OHDA对恒河猴的猴子上调脑微脉管系统中的HLA-DR表达。

• DOI: 10.2147/jir.s67285
• 发表时间: 2014
• 期刊: Journal of inflammation research
• 影响因子: 4.5
• 作者: Joers V;Vermilyea S;Dilley K;Emborg ME
• 通讯作者: Emborg ME

Estrogenic plant consumption predicts red colobus monkey (Procolobus rufomitratus) hormonal state and behavior.

• DOI: 10.1016/j.yhbeh.2012.09.005
• 发表时间: 2012-11
• 期刊: HORMONES AND BEHAVIOR
• 影响因子: 3.5
• 作者: Wasserman, Michael D.;Chapman, Colin A.;Milton, Katharine;Gogarten, Jan F.;Wittwer, Daniel J.;Ziegler, Toni E.
• 通讯作者: Ziegler, Toni E.

Presence of Natural Killer B Cells in Simian Immunodeficiency Virus-Infected Colon That Have Properties and Functions Similar to Those of Natural Killer Cells and B Cells but Are a Distinct Cell Population.

在邻氨酸免疫缺陷病毒感染的结肠中存在天然杀伤B细胞，具有与天然杀伤细胞和B细胞相似的特性和功能，但具有独特的细胞群。

• DOI: 10.1128/jvi.00235-22
• 发表时间: 2022-04-13
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Cogswell, Andrew;Jo, Sungro;Ferguson, Natasha;Gupta, Kajal;Barker, Edward
• 通讯作者: Barker, Edward