MR Quantification of Myocardial Oxygen Utilization in Chronic Myocardial Infarction without Contrast

无对比慢性心肌梗塞心肌氧利用的 MR 定量

• 批准号: 10581563
• 负责人: Keigo Kawaji
• 金额: $ 16.61万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581563
• 关键词: Acute; Affect; American Heart Association; Anatomy; Angiography; Architecture; Biomechanics; Biomedical Engineering; Cardiac; Cardiomyopathies; Cardiovascular Diseases; Catheters; Cause of Death; Cessation of life; Chicago; Chronic; Clinical; Clinical Sciences; Contrast Media; Coronary; Coronary Arteriosclerosis; Coronary Artery Bypass; Data; Databases; Dedications; Detection; Development; Development Plans; Diagnosis; Discipline; Dissection; Echocardiography; Engineering; Evaluation; Exhibits; Functional disorder; Gadolinium; Goals; Heart; Heart Diseases; Image; Individual; Infarction; Injections; Injury; Institution; Ionizing radiation; Knowledge; Lead; MRI Scans; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Measurement; Measures; Medicine; Mentors; Methods; Modality; Motion; Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial tissue; Myocardium; Outcome; Oxygen; Patient imaging; Patients; Pharmaceutical Preparations; Physicians; Physiologic pulse; Protocols documentation; Publishing; Reference Standards; Research; Research Design; Research Personnel; Risk; Roentgen Rays; Scanning; Stents; Stroke; Techniques; Testing; Thallium Myocardial Perfusion Imaging Stress Test; Time; Tissues; Training; United States; United States National Institutes of Health; Universities; Update; Validation; Vascularization; Ventricular Function; Work; brain magnetic resonance imaging; cardiac magnetic resonance imaging; career; career development; clinically significant; cohort; design; follow-up; heart imaging; image reconstruction; imaging approach; imaging modality; improved; magnetic resonance imaging biomarker; new technology; non-invasive imaging; novel; patient oriented; patient oriented research; percutaneous coronary intervention; pre-clinical; rapid detection; response; screening; technique development; technology development

PROJECT SUMMARY The overall goal of this research is to develop a quantitative Magnetic Resonance Imaging (MRI) approach of oxygen utilization that provides a non-invasive and effective imaging test for the assessment of myocardial infarction. According to the most recent Heart Disease and Stroke Statistical Update (2015) published by the American Heart Association, almost 1 out of every 3 deaths in the United States (US) is caused by cardiovascular diseases that include coronary artery disease (CAD) every year. Over $40 billion is spent on cardiac stress tests each year, and nearly 1.5 million individuals are undergo percutaneous coronary intervention or coronary artery bypass surgery to treat severe CAD after nuclear stress test screening. However, the occurrence of obstructive CAD found during invasive stenting/pre-surgical coronary X-ray angiography is less than 40%. The current screening paradigm is expensive, exposes patients to ionizing radiation, and carries additional risks of intimal injury and acute vessel dissection. Cardiac Magnetic Resonance Imaging is a non-invasive imaging modality that currently is the gold standard for the quantitative assessment of ventricular function and myocardial viability evaluation. In particular, LGE can assess viable or non-viable myocardial tissue by interrogating the delayed response to gadolinium-based contrast agent administration. While this LGE assessment is robust, this reference evaluation leaves no room for further improvements via scan-time reduction, and forces any further quantification of underlying tissue pathophysiology to be obtained as separate scans that prolong each patient exam. Accordingly, the 30-plus minute LGE-CMR exam with contrast injection is the widely established, and definitive state-of-art. The scientific premise for this research is that MRI of oxygen utilization provides correlative information on the extent of viable or non-viable tissue without contrast injection. We hypothesize that a non-contrast MR quantification of oxygen utilization in less than one minute of additional scan-time to current routine cardiac MR protocol may offer a new paradigm-shifting, fast alternative evaluation of myocardial infarctions without the need for contrast injection. Hence, we aim to: 1) develop the pulse sequence and advanced image reconstruction methods to quantify myocardial oxygen utilization; 2) validate this method in the patient cohort, and 3) evaluate the proposed cardiac MRI evaluation in a single-center patient imaging setting over a 3-year span in two subject cohorts. The outcome of this work is not only the scientific findings pertaining to the feasibility of the proposed MRI method, but also the compilation of an extensive 200-patient database including all quantitative study measurements of the state-of-the-art MRI evaluations, patient data including outcomes, as well as findings from other modalities such as x-ray catheter (and echo) if these are also performed.

项目摘要 这项研究的总体目标是开发一种定量磁共振成像（MRI）方法 氧气利用率提供了无创和有效的成像测试，以评估心肌 梗塞。根据最近的心脏病和中风统计更新（2015年） 美国心脏协会，在美国每3例死亡中，几乎有1个（美国）是由 每年包括冠状动脉疾病（CAD）在内的心血管疾病。超过400亿美元用于 每年心脏应激测试，近150万人接受经皮冠状动脉 干预措施或冠状动脉搭桥手术在核应激测试筛查后治疗严重的CAD。 但是，在浸润性支架/胸膜前冠状动脉X射线中发现的阻塞性CAD的发生 血管造影小于40％。当前的筛选范式很昂贵，暴露于病人的电离 辐射，并带有内膜损伤和急性血管解剖的额外风险。心脏磁性 共振成像是一种非侵入性成像方式，目前是定量的黄金标准 评估心室功能和心肌生存能力评估。 特别是，LGE可以通过询问对延迟的反应来评估可行或不可行的心肌组织 基于Gadolinium的对比剂给药。虽然此LGE评估很强，但此参考 评估没有通过减少扫描时间进行进一步改进的空间，并进一步迫使 量化潜在的组织病理生理学，以作为延长每个患者的单独扫描 考试。因此，与对比注射的30多分钟LGE-CMR考试是广泛确定的，并且 最先进的。 这项研究的科学前提是，氧利用的MRI提供了有关该研究的相关信息 没有对比度注射的可行或不可生存的组织的程度。我们假设是无对解的MR 在不到一分钟的额外扫描时间中量化氧气利用率到当前常规心脏 MR协议可能会提供新的范式移动，快速对心肌梗死的评估 对比度注入的需求。 因此，我们的目标是：1）开发脉冲序列和高级图像重建方法来量化 心肌氧利用； 2）在患者队列中验证此方法，3）评估提议 在两个受试者队列中，在三年的单一患者成像设置中进行心脏MRI评估。 这项工作的结果不仅是与拟议MRI的可行性有关的科学发现 方法，以及包括所有定量研究（包括所有定量研究）的广泛200名患者数据库的汇编 最先进的MRI评估，包括结果在内的患者数据以及发现的测量 如果还执行了其他模式，例如X射线导管（和回声）。

项目成果

Cell-Laden Gradient Hydrogel Scaffolds for Neovascularization of Engineered Tissues.

• DOI: 10.1002/adhm.202001706
• 发表时间: 2021-04
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: He YJ;Santana MF;Staneviciute A;Pimentel MB;Yang F;Goes J;Kawaji K;Vaicik MK;Abdulhadi R;Hibino N;Papavasiliou G
• 通讯作者: Papavasiliou G