Examining the Relationship between Residential History at Midlife and Prostate Cancer Outcomes
检查中年居住史与前列腺癌结果之间的关系
基本信息
- 批准号:10584259
- 负责人:
- 金额:$ 54.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-16 至 2028-02-29
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAgeAgingBlack raceCancer BiologyCancer PatientCaringCensusesCharacteristicsChronic stressCitiesClinicCommunitiesCommunity HealthcareComplexContinuity of Patient CareCost ControlDataDiagnosisDisadvantagedDiseaseDisease OutcomeDisparityEnvironmentEthnic PopulationExposure toGoalsHealthHealth Care CostsHospitalsIncidenceIncomeIndividualInequityInflammationInterventionInvestigationLearningLifeLife Cycle StagesLinkLongevityLongitudinal StudiesMalignant NeoplasmsMalignant neoplasm of prostateMeasuresMedicareModelingModificationMovementNeeds AssessmentNeighborhoodsOutcomePatient-Focused OutcomesPatientsPatternPennsylvaniaPersonsPhiladelphiaPhysiologicalPoliciesPopulationPovertyProstateRaceRecording of previous eventsRecordsResearchResourcesRiskRisk FactorsRoleStrategic PlanningStructural RacismSuggestionSurvival RateSurvivorsTimeTissuesTumor BiologyVulnerable PopulationsWorkanticancer researchbilling datablack mencancer carecancer diagnosiscancer health disparitycancer survivalcommunity planningcritical perioddata registrydisease disparityeffective interventionenvironment related cancerexperiencefuture implementationhigh riskimprovedinnovationmenmiddle agemortalityneoplasm registrynovelnovel strategiesolder patientoutreachpatient registryprostate cancer modelprostate cancer riskracial disparityracial populationsocioeconomicssurvival disparitysurvivorshiptrendtumor progression
项目摘要
ABSTRACT
Prostate cancer (PCa) is one of a few cancers with more than double the mortality for black men, making this
one of the greatest racial disparities in cancer. Although there are documented disparities in PCa incidence
and mortality related to where people live, it is unclear how residential histories of patients contribute to their
PCa outcomes. Residential environments vary greatly by race and socioeconomics (SES). Still little is known
about how longitudinal exposures to neighborhood risk factors and structural racism captured years before a
cancer diagnosis and into survivorship contribute to PCa disparities along the cancer care continuum.
Additionally, disease outcomes and disparities in PCa are moderated by patient age. Residential history
during midlife is one of the factors that likely influences PCa incidence, progression, mortality, and overall care
of survivors. We propose an innovative linkage of PA cancer registry data to hospital billing records from the
PA Healthcare Cost Containment Council and ~30 years of LexisNexis address data to provide characteristics
of census tracts where patients live. We will use Pennsylvania (PA) Cancer Registry data (N~20,000 patients
in Southeastern PA) to determine the relationship between longitudinal neighborhood characteristics (poverty
trajectories, historical redlining, lending bias, and gentrification) and PCa outcomes at critical points along the
cancer care continuum in a diverse and historic region. These various characteristics will be used to determine
best practices to examine residential histories in risk modeling for PCa outcomes. We will take a novel life
course approach to addressing the role of residential history on
PCa disparities. We hypothesize that cumulative exposures as well
as exposures to neighborhood risk factors during critical periods in
the PCa care trajectory influence disease characteristics at
diagnosis and PCa-mortality. Multilevel regression models will be
conducted to evaluate independent associations of multi-level
factors with PCa outcomes. We will also examine modification by
age. The information that we learn from this study will help us to
understand ways to integrate residential history in cancer research
and strategize about effective interventions to promote prostate
health among high-risk adult populations
We propose a longitudinal, ambidirectional study to address the
following aims: Aim 1: To examine the relationships between PCa
disparities and residential characteristics at diagnosis; Aim 2: To We will employ a life-course framework in this
examine relationships between PCa disparities and accumulated cancer disparities research (based on Ory, et al.
residential history; Aim 3: To examine how residential exposures 2014, AJPM). Disparities occur within an
accumulated specifically during midlife are associated with PCa environmental context. Research focused on
disparities; Aim 4: Conduct a community needs assessment in particular life stages provide unique opportunities
partnership with expert clinician and community planning stakeholders to inform policy, practice, and the health of the
to improve PCa outreach and care community.
摘要
前列腺癌(PCA)是少数几种癌症之一,其死亡率是黑人男性的两倍以上,这使得
癌症中最大的种族差异之一。尽管在PCa的发病率上有记录上的差异
和死亡率与人们居住的地方有关,目前尚不清楚患者的居住史对他们的
PCA结果。居住环境因种族和社会经济(SES)而有很大差异。我们仍然知之甚少
关于社区风险因素和结构性种族主义的纵向暴露是如何在几年前捕获的
癌症诊断和存活率有助于癌症护理连续统一体上的PCA差异。
此外,PCa的疾病结局和差异受患者年龄的影响。住宅史
中年时期是可能影响前列腺癌发病率、进展、死亡率和整体护理的因素之一。
生还者。我们提出了一种创新的将PA癌症登记数据与来自
PA医疗成本控制委员会和~30年LexisNexis地址数据提供特征
病人居住的人口普查区域。我们将使用宾夕法尼亚州(PA)癌症登记数据(N~20,000名患者
在宾夕法尼亚州东南部)以确定纵向邻里特征(贫困)之间的关系
轨迹、历史红线、贷款偏见和士绅化)和沿线关键点的PCA结果
在一个多元化和历史性的地区,癌症护理是一个连续的整体。这些不同的特征将用于确定
在PCA结果的风险建模中检查居住历史的最佳实践。我们要过一种新奇的生活
解决住宅历史在以下方面的作用的课程方法
主成分分析的差异。我们还假设累积风险敞口
在年内关键时期暴露于邻里风险因素
PCA护理轨迹在以下方面影响疾病特征
诊断和PCA-死亡率。多水平回归模型将是
进行多层次的独立关联评估
影响PCA结果的因素。我们还将通过以下方式检查修改
年龄。我们从这项研究中学到的信息将帮助我们
了解将居住史整合到癌症研究中的方法
并制定有效干预措施以促进前列腺癌
高危成人人群的健康状况
我们建议进行一项纵向的双向研究,以解决
以下目标:目标1:检查主成分分析之间的关系
诊断时的差异和居住特征;目标2:我们将在这方面采用生命过程框架
检查PCA差异和累积癌症差异研究之间的关系(基于Ory等人。
住宅历史;目标3:检查住宅暴露于2014年的情况(AJPM)。差异发生在一个
特别是在中年期间积累的是与PCA环境相关的。研究重点放在
差距;目标4:在特定生命阶段进行社区需求评估,提供独特的机会
与专业临床医生和社区规划利益相关者建立伙伴关系,为政策、实践和社区规划的健康提供信息
改善PCA的服务范围和关爱社区。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CHARNITA M. ZEIGLER-JOHNSON其他文献
CHARNITA M. ZEIGLER-JOHNSON的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CHARNITA M. ZEIGLER-JOHNSON', 18)}}的其他基金
Building multi-level models to examine the relationship between obesity and pros
建立多层次模型来研究肥胖与职业之间的关系
- 批准号:
8820828 - 财政年份:2015
- 资助金额:
$ 54.26万 - 项目类别:
Building multi-level models to examine the relationship between obesity and pros
建立多层次模型来研究肥胖与职业之间的关系
- 批准号:
8624549 - 财政年份:2014
- 资助金额:
$ 54.26万 - 项目类别:
Building multi-level models to examine the relationship between obesity and pros
建立多层次模型来研究肥胖与职业之间的关系
- 批准号:
8352627 - 财政年份:2012
- 资助金额:
$ 54.26万 - 项目类别:
Prostate cancer and genes of the one-carbon cycle
前列腺癌和一碳循环基因
- 批准号:
7261325 - 财政年份:2005
- 资助金额:
$ 54.26万 - 项目类别:
Prostate cancer and genes of the one-carbon cycle
前列腺癌和一碳循环基因
- 批准号:
7434467 - 财政年份:2005
- 资助金额:
$ 54.26万 - 项目类别:
Prostate cancer and genes of the one-carbon cycle
前列腺癌和一碳循环基因
- 批准号:
6965720 - 财政年份:2005
- 资助金额:
$ 54.26万 - 项目类别:
Prostate cancer and genes of the one-carbon cycle
前列腺癌和一碳循环基因
- 批准号:
7081326 - 财政年份:2005
- 资助金额:
$ 54.26万 - 项目类别:
Prostate cancer and genes of the one-carbon cycle
前列腺癌和一碳循环基因
- 批准号:
7650245 - 财政年份:2005
- 资助金额:
$ 54.26万 - 项目类别:
Building multi-level models to examine the relationship between obesity and pros
建立多层次模型来研究肥胖与职业之间的关系
- 批准号:
8552079 - 财政年份:
- 资助金额:
$ 54.26万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 54.26万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 54.26万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 54.26万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 54.26万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 54.26万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 54.26万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 54.26万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 54.26万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 54.26万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 54.26万 - 项目类别:
Grant-in-Aid for Scientific Research (C)