The impact of bilingualism on cognitive reserve/resilience using socio-demographically and linguistically diverse populations

双语对社会人口和语言多样化人群的认知储备/弹性的影响

• 批准号: 10584245
• 负责人: Suvarna Alladi
• 金额: $ 94.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10584245
• 关键词: Accounting; Address; Age; Age of Onset; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Amyloid beta-42; Anterior; Attention; Biological; Biological Markers; Brain; Brain Pathology; California; Cerebrum; Chinese; Chinese American; Chronic stress; Cognition; Cognitive; Corpus Callosum; Correlation Studies; Data; Dementia; Diagnostic; Dimensions; Education; English Language; Ethnic Population; Factor Analysis; Frequencies; Functional Magnetic Resonance Imaging; Glial Fibrillary Acidic Protein; Goals; Health; Image; Impaired cognition; India; Individual; Investigation; Joints; Language; Language Development; Learning; Light; Linguistics; Link; Longitudinal cohort; Measures; Mexican Americans; Multilingualism; National Institute of Mental Health; Neurocognitive; Neurosciences; Outcome; Persons; Population; Population Heterogeneity; Population Study; Prevalence; Publishing; Research; Research Project Grants; Role; San Francisco; Series; Severity of illness; Socioeconomic Status; Texas; Universities; Visit; Work; Writing; aging brain; bilingualism; cognitive performance; cognitive reserve; cohort; dementia risk; design; executive function; experience; follow-up; health care availability; health disparity; health disparity populations; healthy aging; imaging biomarker; improved; insight; lens; mild cognitive impairment; molecular marker; neighborhood disadvantage; neural; neurofilament; neuromechanism; novel; protective effect; racial population; resilience; social culture; social health determinants; sociocultural determinant; sociodemographics; stem; study population; tau Proteins

PROJECT SUMMARY Alzheimer’s disease (AD) is the most common form of dementia, impacting millions of people globally. Despite the advancements in understanding fundamental biological constructs of AD and the fact that the global population of bilinguals has outnumbered monolinguals, our understanding of the impact of bilingualism on AD/ADRD (AD and related dementias) remains limited. Previous bilingualism studies suggest that the bilingual experience impacts cognition and AD/ADRD, albeit in varying scale that stems from variabilities in demographic profiles and prevalence of ADRD risk factors. The overarching goal of this study is to directly interrogate the neural and sociocultural aspects of bilingualism across multiple race/ethnic groups, with specific emphasis on deconstructing the links between bilingualism and AD. To accomplish this, the University of California, San Francisco Alzheimer's Disease Research Center in California, the National Institute of Mental Health and Neurosciences in India, and the Health and Aging Brain Study- Health Disparities study in Texas will jointly assemble one of the largest, multicultural, multilingual, and well-characterized cohort of 2,200 individuals representing the world’s most commonly spoken languages: Chinese, Spanish, Kannada, and English languages. This study team will collect cross-sectional data on cognition, imaging, molecular biomarkers, language background, and SDOH, and follow-up language, SDOH, and cognitive data for three years. We intend to build a theoretical framework on the cognitive role of bilingualism by deconstructing bilingualism and examining its features via a multidimensional lens. We will examine the inter-relationship of this multidimensional bilingualism construct with cognition and social determinants of health using structural and functional magnetic resonance imaging and AD/ADRD molecular biomarkers. Our central hypothesis is that specific bilingualism features would influence the cognitive trajectory by improving executive control through the mechanism of brain and cognitive reserve even after accounting for social determinants of health and AD/ADRD biomarkers. This proposed study will provide novel mechanistic insights into the multidimensionality of bilingualism and create an exclusive opportunity to study the cognitive relevance of bilingualism using socio-demographically and linguistically diverse cohorts. This study also has the unique settings to evaluate the generalizability of the proposed cognitive-bilingualism theoretical framework across populations that differ in sociocultural, demographic, and linguistic background.

项目总结