MITOCHONDRIAL FUNCTION IN PEDIATRIC OBESITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将调查线粒体作为儿童胰岛素抵抗发展的非侵入性预测标志的功能。这项研究将评估肥胖儿童与非肥胖儿童的基线线粒体功能，以： A.确定与健康的非肥胖儿童相比，儿童肥胖儿童的线粒体功能是否受损。 B.检查肥胖和非肥胖儿童线粒体功能与胰岛素抵抗的关系 确定青春期阶段对肥胖和非肥胖儿童线粒体功能的影响。 这项研究将在一项纵向队列研究中确定青春期前/青春期早期肥胖儿童与青春期前非肥胖儿童相比，线粒体功能障碍与胰岛素抵抗发生的时间和关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study will investigate mitochondrial function as a non-invasive predictive marker for the development of insulin resistance in children. Study will evaluate baseline mitochondrial function in obese children compared to non-obese children to: A. Determine whether children with pediatric obesity have impaired mitochondrial function compared to healthy non-obese children. B. Examine the relationship between mitochondrial function and insulin resistance in obese and non-obese children C. Determine the impact of pubertal stage on mitochondrial function in obese and non-obese children. The study will determine in a longitudinal cohort study the timing and relationship of mitochondrial dysfunction to the development of insulin resistance in prepubertal/early pubertal obese children compared to prepubertal non-obese children.