MITOCHONDRIAL FUNCTION IN PEDIATRIC OBESITY

小儿肥胖症的线粒体功能

• 批准号: 7731335
• 负责人: Amy Debra Fleischman
• 金额: $ 0.52万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731335
• 关键词: Child; Childhood; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Grant; Institution; Insulin Resistance; Invasive; Mitochondria; Non obese; Obesity; Research; Research Personnel; Resources; Source; Staging; Time; United States National Institutes of Health; mitochondrial dysfunction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study will investigate mitochondrial function as a non-invasive predictive marker for the development of insulin resistance in children. Study will evaluate baseline mitochondrial function in obese children compared to non-obese children to: A. Determine whether children with pediatric obesity have impaired mitochondrial function compared to healthy non-obese children. B. Examine the relationship between mitochondrial function and insulin resistance in obese and non-obese children C. Determine the impact of pubertal stage on mitochondrial function in obese and non-obese children. The study will determine in a longitudinal cohort study the timing and relationship of mitochondrial dysfunction to the development of insulin resistance in prepubertal/early pubertal obese children compared to prepubertal non-obese children.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该研究将研究线粒体功能，作为儿童胰岛素抵抗发展的非侵入性预测标记。 与非肥胖儿童相比，研究将评估肥胖儿童的基线线粒体功能： 答：确定儿童肥胖儿童是否与健康的非肥胖儿童相比是否损害了线粒体功能。 B.检查肥胖儿童中线粒体功能与胰岛素抵抗之间的关系 C.确定青春期阶段对肥胖儿童和非肥胖儿童线粒体功能的影响。 该研究将在一项纵向队列研究中确定与青春期/青春期早期肥胖儿童相比，线粒体功能障碍与胰岛素抵抗的发展与胰岛素抵抗的发展。