Rheumatoid Arthritis and Respiratory Outcomes in Prospective Cohorts

未来队列中的类风湿关节炎和呼吸系统结局

基本信息

  • 批准号:
    9262145
  • 负责人:
  • 金额:
    $ 15.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-05-01 至 2021-04-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Candidate: Dr. Sparks is an Instructor of Medicine in the Section of Clinical Sciences (SCS), Division of Rheumatology, Immunology and Allergy at Brigham and Women's Hospital (BWH) where he has 88% of his full-time professional effort committed to his research projects. He has 12% of his time devoted to clinical care at BWH and teaching at Harvard Medical School (HMS). He has received a Master of Medical Sciences degree in patient-oriented research from HMS, and a career development award from the Rheumatology Research Foundation. His dedication to clinical investigation is evident by 9 total and 6 first-author original research publications, presentations at national and international scientific meetings, and service on scientific committees. He has an experienced team of senior mentors and strong institutional support in an environment that fosters training in patient-oriented research. In line with his career development plan for this award, his immediate career goals are to expand his prior findings on increased risk of respiratory mortality for patients with rheumatoid arthritis (RA) using two prospective cohorts that will serve as the foundation for future independent research endeavors linking RA pathogenesis with subsequent respiratory outcomes. With the assistance of his expert mentoring team, led by Dr. Elizabeth Karlson, he will obtain training in advanced statistical methods in outcomes research, pulmonary evaluation and phenotyping, and integration of biomarkers in his studies to complete the aims of this proposal. The research training, mentorship, and results that arise from this project will lay the groundwork so that he can achieve his long-term goal to become an independent scientist in the field of RA epidemiology. Ultimately, he plans to develop interventions that prevent or decrease the respiratory burden of RA patients while informing the pathogenesis of respiratory diseases. Environment: Dr. Sparks has a commitment from his Department and Division at BWH that ensures at least 75% protected time for the research and career development activities detailed in this K23 proposal. He has institutional support from a recruitment package as well as supplemental salary support though his primary mentor's funding. He has access to subjects with RA for recruitment in the Brigham RA Sequential Study (BRASS), an ongoing 13-year longitudinal cohort, as well as >2,500 RA patients seen annually at the BWH Arthritis Center. Since BWH is a leading academic hospital for rheumatic and pulmonary diseases, he will have access to recruit adequate numbers of subjects for this project and future studies. He will obtain training in pulmonary phenotyping at the BWH Pulmonary Physiology Center and RA/Interstitial Lung Disease Clinic. In addition, he has full access to data in the Nurses' Health Study (NHS), through the BWH Channing Division of Network Medicine. The NHS is composed of 121,700 women followed since 1976 with data on RA, respiratory outcomes, and covariates such as smoking. He has access to data on biomarkers from banked samples in a subset of women in the NHS who later developed RA. He has full access to data already collected and biospecimens in BRASS through the Division and SCS at BWH. Translational and patient-oriented research expertise is available at HMS, the Harvard Clinical and Translational Science Center, and the Harvard T.H. Chan School of Public Health. At the latter, he will take courses in causal inference, programming, biomarkers, and longitudinal analysis to acquire skills for this proposal. Dr. Sparks will have access to the larger BWH and Harvard research communities for presentations and feedback. In addition to protected time and financial support, Dr. Sparks has an office, computer with word processing and statistical software, telephone, copy/fax machine, and administrative support provided by the Division and SCS that will be extended during this award. Research: The overall hypothesis of this project is that inflammation and autoimmunity contribute to the respiratory burden of RA. This hypothesis is based on prior data demonstrating increased respiratory mortality among women with seropositive RA independent of smoking. In addition, preliminary data suggest that serum inflammatory markers and anti-citrullinated protein antibodies are associated with increased respiratory burden among patients with RA. In this K23 proposal, Dr. Sparks will build upon these findings using two prospective cohorts, the NHS and BRASS. He will utilize the strengths of both cohorts to examine complementary hypotheses. The NHS is comprised of detailed and lengthy data on a large cohort of women in the United States. Follow-up data before and after RA diagnosis in the NHS are available for examining how pre-RA factors affect outcomes occurring after RA diagnosis. BRASS has detailed data on clinical and RA-specific measures including disease activity, medications, and functional status in a large cohort of RA patients. First, this proposal will determine whether women with RA in the NHS are at increased risk for asthma, chronic obstructive pulmonary disease, and respiratory mortality. Second, this proposal will examine whether inflammatory biomarkers are associated with dyspnea and pulmonary comorbidities in BRASS. In this aim, the candidate will recruit subjects to prospectively receive additional respiratory measures. Finally, this proposal will examine whether anti-citrullinated protein antibodies are associated with respiratory outcomes when measured in the pre-clinical RA phase and patients with RA. By investigating the roles of inflammation and autoimmunity in respiratory outcomes in RA, Dr. Sparks will obtain training in statistical analysis, recruitment, pulmonary phenotyping, and biomarkers that position him to become a leader in clinical investigation.
 描述(由申请人提供): 候选人:Sparks 博士是布莱根妇女医院 (BWH) 风湿病学、免疫学和过敏科临床科学科 (SCS) 的医学讲师,他 88% 的全职专业精力致力于他的研究项目。他将 12% 的时间投入到 BWH 的临床护理和哈佛医学院 (HMS) 的教学工作。他获得了英国皇家医学院以患者为导向的研究的医学科学硕士学位,以及风湿病研究基金会的职业发展奖。他对临床研究的奉献精神体现在总共 9 篇原创研究出版物和 6 篇第一作者原创研究出版物、在国内和国际科学会议上的演讲以及在科学委员会的服务中。他拥有一支经验丰富的高级导师团队和强大的机构支持,在促进以患者为导向的研究培训的环境中。根据他获得该奖项的职业发展计划,他的近期职业目标是扩展他之前关于患有以下疾病的患者呼吸系统死亡风险增加的发现: 使用两个前瞻性队列研究类风湿性关节炎 (RA),这将作为未来将 RA 发病机制与随后的呼吸系统结果联系起来的独立研究工作的基础。在伊丽莎白·卡尔森博士领导的专家指导团队的协助下,他将获得结果研究、肺部评估和表型分析以及生物标志物整合等方面的高级统计方法方面的培训,以完成该提案的目标。该项目产生的研究培训、指导和成果将为他实现成为 RA 流行病学领域的独立科学家的长期目标奠定基础。最终,他计划开发干预措施,预防或减轻 RA 患者的呼吸负担,同时了解呼吸系统疾病的发病机制。环境:Sparks 博士在 BWH 的部门和部门做出承诺,确保至少 75% 的受保护时间用于本 K23 提案中详述的研究和职业发展活动。他通过招聘计划获得机构支持,并通过其主要导师的资助获得补充工资支持。他可以在 Brigham RA 序贯研究 (BRASS)(一项正在进行的 13 年纵向队列)中招募 RA 受试者,以及每年在 BWH 关节炎中心就诊的超过 2,500 名 RA 患者。由于 BWH 是一家领先的风湿病和肺部疾病学术医院,他将有机会为该项目和未来的研究招募足够数量的受试者。他将在 BWH 肺生理学中心和 RA/间质性肺病诊所接受肺表型分析培训。此外,他还可以通过 BWH Channing 网络医学部门完全访问护士健康研究 (NHS) 中的数据。 NHS 自 1976 年以来对 121,700 名女性进行了跟踪调查,提供有关 RA、呼吸系统结果和吸烟等协变量的数据。他可以从 NHS 中后来患上 RA 的一部分女性的银行样本中获取生物标志物数据。他可以完全访问通过 BWH 部门和 SCS 收集的 BRASS 数据和生物样本。 HMS、哈佛临床和转化科学中心以及哈佛 T.H. 提供转化和以患者为导向的研究专业知识。陈公共卫生学院。在后者,他将学习因果推理、编程、生物标记和纵向分析课程,以获得该提案的技能。 Sparks 博士将能够接触到更大的 BWH 和哈佛大学研究社区进行演讲和反馈。除了受保护的时间和财务支持外,Sparks 博士还拥有一间办公室、带有文字处理和统计软件的计算机、电话、复印/传真机以及由该部门和 SCS 提供的行政支持,这些支持将在获奖期间得到扩展。研究:该项目的总体假设是炎症和自身免疫导致 RA 的呼吸负担。这一假设基于先前的数据,该数据表明血清阳性 RA 女性的呼吸道死亡率增加,与吸烟无关。此外,初步数据表明,血清炎症标志物和抗瓜氨酸蛋白抗体与 RA 患者呼吸负担增加有关。在这项 K23 提案中,Sparks 博士将利用两个前瞻性队列(NHS 和 BRASS)以这些发现为基础。他将利用两个群体的优势来检验互补的假设。 NHS 由美国大量女性的详细而冗长的数据组成。 NHS 诊断 RA 之前和之后的随访数据可用于检查 RA 前因素如何影响 RA 诊断后的结果。 BRASS 拥有大量 RA 患者的临床和 RA 特异性指标的详细数据,包括疾病活动度、药物治疗和功能状态。首先,该提案将确定 NHS 中患有 RA 的女性患哮喘、慢性阻塞性肺病和呼吸系统死亡的风险是否增加。其次,该提案将检查炎症生物标志物是否与 BRASS 呼吸困难和肺部合并症相关。为此,候选人将招募受试者前瞻性地接受额外的呼吸措施。最后,该提案将检查在临床前 RA 阶段和 RA 患者中测量时,抗瓜氨酸蛋白抗体是否与呼吸结果相关。通过研究炎症和自身免疫在 RA 呼吸系统结局中的作用,Sparks 博士将获得统计分析、招募、肺表型分析和生物标志物方面的培训,这使他能够成为临床研究的领导者。

项目成果

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Jeffrey Andrew Sparks其他文献

Jeffrey Andrew Sparks的其他文献

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{{ truncateString('Jeffrey Andrew Sparks', 18)}}的其他基金

Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases
系统性自身免疫性风湿病患者 COVID-19 后的免疫学和临床后遗症
  • 批准号:
    10583192
  • 财政年份:
    2023
  • 资助金额:
    $ 15.79万
  • 项目类别:
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
类风湿关节炎相关自身抗体、关节炎症和 RA 相关间质性肺病
  • 批准号:
    10491725
  • 财政年份:
    2021
  • 资助金额:
    $ 15.79万
  • 项目类别:
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
类风湿关节炎相关自身抗体、关节炎症和 RA 相关间质性肺病
  • 批准号:
    10647761
  • 财政年份:
    2021
  • 资助金额:
    $ 15.79万
  • 项目类别:
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
类风湿关节炎相关自身抗体、关节炎症和 RA 相关间质性肺病
  • 批准号:
    10207955
  • 财政年份:
    2021
  • 资助金额:
    $ 15.79万
  • 项目类别:
Respiratory Diseases, Genetics, and Rheumatoid Arthritis Risk
呼吸系统疾病、遗传学和类风湿关节炎风险
  • 批准号:
    9810123
  • 财政年份:
    2019
  • 资助金额:
    $ 15.79万
  • 项目类别:

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